Costs of orphan medicinal products: longitudinal analysis of expenditure in Wales by Yankier Pijeira Perez, Eifiona Wood, Dyfrig A Hughes

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Liothyronine for hypothyroidism: a candidate for disinvestment or in need of further research? A value of information analysis by Dyfrig A Hughes, Pippa Anderson, Adrian Heald, Konstantinos Skiadas

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Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions by Girvan Burnside, Munir Pirmohamed, Rostam Osanlou, Dyfrig A Hughes, Lauren Walker

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Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care by Emily A. F. Holmes, Sharman D. Harris, Alison Hughes, Noel Craine, Dyfrig A. Hughes

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Cost-effectiveness of home versus hospital management of children at onset of type 1 diabetes: the DECIDE randomised controlled trial by John W Gregory, Dyfrig A Hughes, Timothy Pickles, Julia Townson, Rebecca Playle, Michael Robling, Zoe McCarroll

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Value of improving patient safety: health economic considerations for rapid response systems–a rapid review of the literature and expert round table by Dyfrig A Hughes, Emily A Holmes, Christian Subbe, Cor Kalkman, John Welch, Sally Lewis, Ralph So, Sumeshni Tranka

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Appropriate design and reporting of superiority, equivalence and non-inferiority clinical trials incorporating a benefit–risk assessment: the BRAINS study including expert workshop... by Nikki Totton, Steven A Julious, Elizabeth Coates, Dyfrig A Hughes, Jonathan A Cook, Katie Biggs, Catherine Hewitt, Simon Day, Andrew Cook

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EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis a... by Ian Sinha, Dyfrig A Hughes, Michelle Maden, Stephen Turner, Sofia Cividini, Sarah Donegan, Giovanna Culeddu, Katie Rose, Olive Fulton, Catrin Tudur Smith

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Patient‐Led Urate Self‐Monitoring to Improve Clinical Outcomes in People With Gout: A Feasibility Study by Toni J. F. Michael, Daniel F. B. Wright, Jian S. Chan, Matthew J. Coleshill, Parisa Aslani, Dyfrig A. Hughes, Richard O. Day, Sophie L. Stocker

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Developing patient-centred, feasible alternative care for adult emergency department users with epilepsy: protocol for the mixed-methods observational ‘Collaborate’ project by Steve Goodacre, Myfanwy Morgan, Dyfrig A Hughes, Adam J Noble, Alison McKinlay, Leone Ridsdale, Amy Mathieson, EA Holmes, Jon Mark Dickson, Mike Jackson, Anthony G Marson

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Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network... by John Cullinan, Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding

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The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE) by Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding

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A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE) by Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding

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Seizure First Aid Training For people with Epilepsy (SAFE) frequently attending emergency departments and their significant others: results of a UK multi-centre randomised controll... by Steve Goodacre, Myfanwy Morgan, Dyfrig A Hughes, Adam J Noble, Leone Ridsdale, Anthony G Marson, Emily A Holmes, Dee Snape, Sarah Nevitt, Catrin Tudur-Smith, Mark Buchanan, Jane McVicar, Elizabeth MacCallum

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Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epileps... by Girvan Burnside, Munir Pirmohamed, Dyfrig A Hughes, Paula R Williamson, Anthony Guy Marson, Claire Taylor, Phil E M Smith, John Paul Leach, Gus Baker, Catrin Tudur-Smith, Richard Appleton, Michael Johnson, Silviya Balabanova, Graeme Sills, Catrin Plumpton

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Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous... by Nefyn H. Williams, Alison Jenkins, Nia Goulden, Zoe Hoare, Dyfrig A. Hughes, Eifiona Wood, Nadine E. Foster, David Walsh, Dawn Carnes, Valerie Sparkes, Elaine M. Hay, John Isaacs, Kika Konstantinou, Dylan Morrissey, Jaro Karppinen, Stephane Genevay, Clare Wilkinson

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A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study by Andrea L Jorgensen, Catherine Orrell, Catriona Waitt, Cheng-Hock Toh, Christine Sekaggya-Wiltshire, Dyfrig A Hughes, Elizabeth Allen, Emmy Okello, Gayle Tatz, Giovanna Culeddu, Innocent G Asiimwe, Jerome Roy Semakula, Johannes P Mouton, Karen Cohen, Marc Blockman, Mohammed Lamorde, Munir Pirmohamed

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The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial by Bernie Carter, Lucy Bray, Nadia al-Najjar, Agnès Tort Piella, Catrin Tudur-Smith, Catherine Spowart, Amber Collingwood, Holly Crudgington, Janet Currier, Dyfrig A. Hughes, Eifiona Wood, Rachael Martin, Christopher Morris, Deborah Roberts, Alison Rouncefield-Swales, Heather Sutherland, Victoria Watson, Georgia Cook, Luci Wiggs, Paul Gringras, Deb Pal

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Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasib... by Peter Bower, Veronika Williams, Dyfrig A Hughes, Robert Horne, Jenny McSharry, Ly-Mee Yu, Andrew Farmer, Cassandra Kenning, Lionel Tarassenko, Emily A Holmes, Julie Allen, Kiera Bartlett, Yuan Chi, David French, Bernard Gudgin, Louise Locock, Lisa Miles, Nikki Newhouse, Rustam Rea, Evgenia Riga, Carmelo Velardo, Nicola Williams

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Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D pilot): results of a feasibility... by The SuMMiT-D Collaborative Group, Andrew J. Farmer, Julie Allen, Y. Kiera Bartlett, Peter Bower, Yuan Chi, David P. French, Bernard Gudgin, Emily Holmes, Robert Horne, Dyfrig A. Hughes, Louise Jones, Cassandra Kenning, Louise Locock, Jennifer McSharry, Lisa Miles, Nicola Newhouse, Rustam Rea, Stephanie Robinson, Lionel Tarassenko, Carmelo Velardo, Nicola Williams, Ly-Mee Yu

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