Associations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial by Maria R. Khan, PhD, MPH, Mary Acri, PhD, Kaoon (Francois) Ban, MPH, Joy D. Scheidell, PhD, MPH, Elizabeth R. Stevens, PhD, MPH, Prima Manandhar-Sasaki, MSc, Dyanna Charles, MPH, Natalie E. Chichetto, PhD, MSW, Stephen Crystal, PhD, Adam J. Gordon, MD, MPH, Brandon D.L. Marshall, PhD, E. Jennifer Edelman, MD, MHS, Amy C. Justice, MD, PhD, Scott R. Braithwaite, MD, MS, Ellen C. Caniglia, ScD

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