A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples by Wenpin Hou, Zhicheng Ji, Zeyu Chen, E. John Wherry, Stephanie C. Hicks, Hongkai Ji

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A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. by Alison Crawford, Jill Marie Angelosanto, Kim Lynn Nadwodny, Shawn D Blackburn, E John Wherry

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Correction: Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity. by Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin

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Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity. by Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin

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The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. by Daniel P Beiting, Shinya Hidano, Julie E Baggs, Jeanne M Geskes, Qun Fang, E John Wherry, Christopher A Hunter, David S Roos, Sara Cherry

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310 T cell intrinsic DNA damage and repair response as a novel marker associated with clinical response to PD-1 blockade by Alexander Huang, Claire Friedman, Yuki Muroyama, Sasikanth Manne, Divij Mathew, Lakshmi Chilukuri, Allison Greenplate, Ramin Herati, E John Wherry, Derek Oldridge, Caiyue Xu, Dimitriy Zamarin

1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX by Omar Khan, Sasikanth Manne, E John Wherry, Josephine R Giles, Amy E Baxter, Shin Foong Ngiow, Yinghui Jane Huang, Simone L Park, Jennifer E Wu

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. by George Makedonas, Natalie Hutnick, Danielle Haney, Alexandra C Amick, Jay Gardner, Gabriela Cosma, Adam R Hersperger, Douglas Dolfi, E John Wherry, Guido Ferrari, Michael R Betts

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Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. by Nobuhiro Nakamoto, Hyosun Cho, Abraham Shaked, Kim Olthoff, Mary E Valiga, Mary Kaminski, Emma Gostick, David A Price, Gordon J Freeman, E John Wherry, Kyong-Mi Chang

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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade by Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Josephine R. Giles, Amy E. Baxter, Lanwei Xu, Phyllis A. Gimotty, Robert B. Faryabi, E. John Wherry, Warren S. Pear, Martha S. Jordan

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Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity. by Brian J Laidlaw, Vilma Decman, Mohammed-Alkhatim A Ali, Michael C Abt, Amaya I Wolf, Laurel A Monticelli, Krystyna Mozdzanowska, Jill M Angelosanto, David Artis, Jan Erikson, E John Wherry

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High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline by Guanning Wang, Olga Lyudovyk, Justin Y. Kim, Ya-Hui Lin, Yuval Elhanati, Divij Mathew, E. John Wherry, Ramin S. Herati, Allison R. Greenplate, Benjamin Greenbaum, Santosha A. Vardhana, Alexander C. Huang

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Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. by Hyun Mu Shin, Varun N Kapoor, Gwanghun Kim, Peng Li, Hang-Rae Kim, M Suresh, Susan M Kaech, E John Wherry, Liisa K Selin, Warren J Leonard, Raymond M Welsh, Leslie J Berg

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1522 Revitalizing systemic immune responses in progressive NSCLC using FLT3L and SBRT by Tibor Keler, Balazs Halmos, Divij Mathew, Chandan Guha, Jeffrey M Levsky, E John Wherry, Josephine R Giles, Nitin Ohri, Shin Foong Ngiow, KC Wumesh, Madhur Garg, Haiying Cheng, Rasim Gucalp, William Bodner, Rafi Kabarriti, Claudia Gutierrez-Chavez, Adel Zakharia, Shalom Kalnicki, Michael J Yellin

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection by Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe

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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. by Prakash K Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G Junger, Simon C Robson, E John Wherry, Galit Alter, Philip J R Goulder, Paul Klenerman, Arlene H Sharpe, Georg M Lauer, W Nicholas Haining

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Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma by David L. Bajor, Rosemarie Mick, Matthew J. Riese, Alex C. Huang, Brendan Sullivan, Lee P. Richman, Drew A. Torigian, Sangeeth M. George, Erietta Stelekati, Fang Chen, J. Joseph Melenhorst, Simon F. Lacey, Xiaowei Xu, E. John Wherry, Tara C. Gangadhar, Ravi K. Amaravadi, Lynn M. Schuchter, Robert H. Vonderheide

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PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma by Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi

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PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma by Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi

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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 by Sokratis A. Apostolidis, Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Amy E. Baxter, Allison R. Greenplate, Allison R. Greenplate, Cécile Alanio, Cécile Alanio, Cécile Alanio, Mohamed Abdel-Hakeem, Mohamed Abdel-Hakeem, Derek A. Oldridge, Derek A. Oldridge, Derek A. Oldridge, Josephine R. Giles, Josephine R. Giles, Josephine R. Giles, Jennifer E. Wu, Jennifer E. Wu, Jennifer E. Wu, Zeyu Chen, Zeyu Chen, Yinghui Jane Huang, Yinghui Jane Huang, Jonathan Belman, Jonathan Belman, Ajinkya Pattekar, Ajinkya Pattekar, Sasikanth Manne, Sasikanth Manne, Oliva Kuthuru, Oliva Kuthuru, Jeanette Dougherty, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Alexander C. Huang, Alexander C. Huang, Laura A. Vella, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Scott E. Hensley, Lubica Rauova, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Mortimer Poncz, Charles S. Abrams, E. John Wherry, E. John Wherry, E. John Wherry, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck

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