Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation by Craig P. McEntee, Craig P. McEntee, Conor M. Finlay, Conor M. Finlay, Ed C. Lavelle, Ed C. Lavelle

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Editorial: Challenges in Vaccinology by Ed C. Lavelle, Rita Carsetti, Winfried F. Pickl, Ursula Wiedermann

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Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells. by Graham A Tynan, Anne McNaughton, Andrew Jarnicki, Takao Tsuji, Ed C Lavelle

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Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells by Ewa Oleszycka, Ewa Oleszycka, Eoin C. O’Brien, Michael Freeley, Ed C. Lavelle, Aideen Long

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The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation by Filipa Lebre, Rukmani Sridharan, Michael J. Sawkins, Daniel J. Kelly, Fergal J. O’Brien, Ed C. Lavelle

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UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation. by Emma B O'Connor, Natalia Muñoz-Wolf, Gemma Leon, Ed C Lavelle, Kingston H G Mills, Patrick T Walsh, Richard K Porter

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Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines by Aqel Albutti, Stephanie Longet, Craig P. McEntee, Shauna Quinn, Alex Liddicoat, Cristiana Rîmniceanu, Nils Lycke, Lydia Lynch, Susanna Cardell, Ed C. Lavelle

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Alum Activates the Bovine NLRP3 Inflammasome by Ciaran Harte, Ciaran Harte, Aoife L. Gorman, S. McCluskey, Michael Carty, Andrew G. Bowie, C. J. Scott, Kieran G. Meade, Ed C. Lavelle

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Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing by Danielle M. Clancy, Graeme P. Sullivan, Hannah B.T. Moran, Conor M. Henry, Emer P. Reeves, Noel G. McElvaney, Ed C. Lavelle, Seamus J. Martin

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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine. by Pádraig J Ross, Caroline E Sutton, Sarah Higgins, Aideen C Allen, Kevin Walsh, Alicja Misiak, Ed C Lavelle, Rachel M McLoughlin, Kingston H G Mills

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Correction: Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes. by Ismail M Meraz, Claire H Hearnden, Xuewu Liu, Marie Yang, Laura Williams, David J Savage, Jianhua Gu, Jessica R Rhudy, Kenji Yokoi, Ed C Lavelle, Rita E Serda

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Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes. by Ismail M Meraz, Claire H Hearnden, Xuewu Liu, Marie Yang, Laura Williams, David J Savage, Jianhua Gu, Jessica R Rhudy, Kenji Yokoi, Ed C Lavelle, Rita E Serda

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Technological Approaches for Improving Vaccination Compliance and Coverage by Céline Lemoine, Aneesh Thakur, Danina Krajišnik, Romain Guyon, Stephanie Longet, Agnieszka Razim, Sabina Górska, Ivana Pantelić, Tanja Ilić, Ines Nikolić, Ed C. Lavelle, Andrzej Gamian, Snežana Savić, Anita Milicic

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A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma. by Sergio Arancibia, Cecilia Espinoza, Fabián Salazar, Miguel Del Campo, Ricardo Tampe, Ta-Ying Zhong, Pablo De Ioannes, Bruno Moltedo, Jorge Ferreira, Ed C Lavelle, Augusto Manubens, Alfredo E De Ioannes, María Inés Becker

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TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals by José M. Jiménez, Michelle L. Salazar, Sergio Arancibia, Javiera Villar, Fabián Salazar, Fabián Salazar, Gordon D. Brown, Ed C. Lavelle, Luisa Martínez-Pomares, Jafet Ortiz-Quintero, Sergio Lavandero, Augusto Manubens, María Inés Becker, María Inés Becker

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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. by Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle

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Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21 by Emer E. Hackett, Hugo Charles-Messance, Seónadh M. O’Leary, Laura E. Gleeson, Natalia Muñoz-Wolf, Sarah Case, Anna Wedderburn, Daniel G.W. Johnston, Michelle A. Williams, Alicia Smyth, Mireille Ouimet, Kathryn J. Moore, Ed C. Lavelle, Sinéad C. Corr, Stephen V. Gordon, Joseph Keane, Frederick J. Sheedy

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Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses by Mimmi LE Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C Williams, Ming Yang, Roisin I Lynch, Eimear Lagan, Filipa M Lebre, Aoife L Gorman, Bojan Stojkovic, Adrian P Bracken, Christian Frezza, Frederick J Sheedy, Eoin M Scanlan, Luke AJ O'Neill, Stephen V Gordon, Ed C Lavelle

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Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection. by Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin

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Caspase-11 promotes allergic airway inflammation by Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill

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