Ataxin-3 and its E3 partners: Implications for Machado-Joseph disease 由 Thomas M Durcan, Edward A Fon

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Structure and function of parkin, PINK1 and DJ-1, the three musketeers of neuroprotection 由 Jean-Francois eTrempe, Edward A. Fon

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Long-term potentiation in isolated dendritic spines. 由 Amadou T Corera, Guy Doucet, Edward A Fon

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Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson’s Disease 由 Thomas Goiran, Mohamed A. Eldeeb, Cornelia E. Zorca, Edward A. Fon

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Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development. 由 Wenjing Ruan, Nicolas Unsain, Julie Desbarats, Edward A Fon, Philip A Barker

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ScRNAbox: empowering single-cell RNA sequencing on high performance computing systems 由 Rhalena A. Thomas, Michael R. Fiorini, Saeid Amiri, Edward A. Fon, Sali M. K. Farhan

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Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation 由 Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon

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A dataset of multi-contrast unbiased average MRI templates of a Parkinson's disease population 由 Victoria Madge, Vladimir S Fonov, Yiming Xiao, Lucy Zou, Courtney Jackson, Ronald B Postuma, Alain Dagher, Edward A Fon, D Louis Collins

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Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria 由 Marta Vranas, Yang Lu, Shafqat Rasool, Nathalie Croteau, Jonathan D. Krett, Véronique Sauvé, Kalle Gehring, Edward A. Fon, Thomas M. Durcan, Jean-François Trempe

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Aberrant neurophysiological signaling associated with speech impairments in Parkinson’s disease 由 Alex I. Wiesman, Peter W. Donhauser, Clotilde Degroot, Sabrina Diab, Shanna Kousaie, Edward A. Fon, Denise Klein, Sylvain Baillet, PREVENT-AD Research Group, Quebec Parkinson Network

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A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types 由 Carol X.-Q. Chen, Narges Abdian, Gilles Maussion, Rhalena A. Thomas, Iveta Demirova, Eddie Cai, Mahdieh Tabatabaei, Lenore K. Beitel, Jason Karamchandani, Edward A. Fon, Thomas M. Durcan

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Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing 由 Carol X.-Q. Chen, Zhipeng You, Narges Abdian, Julien Sirois, Irina Shlaifer, Mahdieh Tabatabaei, Marie-Noëlle Boivin, Lydiane Gaborieau, Jason Karamchandani, Lenore K. Beitel, Edward A. Fon, Thomas M. Durcan

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Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons 由 Razan Sheta, Maxime Teixeira, Walid Idi, Marion Pierre, Aurelie de Rus Jacquet, Vincent Emond, Cornelia E. Zorca, Benoît Vanderperre, Thomas M. Durcan, Edward A. Fon, Frédéric Calon, Mohamed Chahine, Abid Oueslati

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Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson’s associated GBA gene 由 Carol X.-Q. Chen, Eric Deneault, Narges Abdian, Zhipeng You, Julien Sirois, Michael Nicouleau, Irina Shlaifer, Lorenza Villegas, Marie-Noëlle Boivin, Lydiane Gaborieau, Jason Karamchandani, Lenore K. Beitel, Edward A. Fon, Thomas M. Durcan

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Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy 由 Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon

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Activation of parkin by a molecular glue 由 Véronique Sauvé, Eric Stefan, Nathalie Croteau, Thomas Goiran, Rayan Fakih, Nupur Bansal, Adelajda Hadzipasic, Jing Fang, Paramasivam Murugan, Shimin Chen, Edward A. Fon, Warren D. Hirst, Laura F. Silvian, Jean-François Trempe, Kalle Gehring

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CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids 由 Rhalena A. Thomas, Julien Sirois, Shuming Li, Alexandre Gestin, Ghislaine Deyab, Valerio E.C. Piscopo, Paula Lépine, Meghna Mathur, Carol X.-Q. Chen, Vincent Soubannier, Taylor M. Goldsmith, Lama Fawaz, Thomas M. Durcan, Edward A. Fon

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Disruption of GRIN2B Impairs Differentiation in Human Neurons 由 Scott Bell, Gilles Maussion, Malvin Jefri, Huashan Peng, Jean-Francois Theroux, Heika Silveira, Vincent Soubannier, Hanrong Wu, Peng Hu, Ekaterina Galat, S. Gabriela Torres-Platas, Camille Boudreau-Pinsonneault, Liam A. O'Leary, Vasiliy Galat, Gustavo Turecki, Thomas M. Durcan, Edward A. Fon, Naguib Mechawar, Carl Ernst

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Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils 由 Stephanie Tullo, Janice Park, Daniel Gallino, Megan Park, Kristie Mar, Vladislav Novikov, Rodrigo Sandoval Contreras, Raihaan Patel, Esther del Cid-Pellitero, Edward A. Fon, Wen Luo, Irina Shlaifer, Thomas M. Durcan, Marco A. M. Prado, Vania F. Prado, Gabriel A. Devenyi, M. Mallar Chakravarty

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Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models 由 Jack Wuyang Jin, Xuelai Fan, Esther del Cid-Pellitero, Xing-Xing Liu, Limin Zhou, Chunfang Dai, Ebrima Gibbs, Wenting He, Hongjie Li, Xiaobin Wu, Austin Hill, Blair R. Leavitt, Neil Cashman, Lidong Liu, Jie Lu, Thomas M. Durcan, Zhifang Dong, Edward A. Fon, Yu Tian Wang

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