The Missing Link between (Un)druggable and Degradable KRAS by Elena De Vita, Maria Maneiro, Edward W. Tate

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Dynamics and Molecular Interactions of GPI-Anchored CD59 by Tomas B. Voisin, Emma C. Couves, Edward W. Tate, Doryen Bubeck

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Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gαi/o Pathway by Matilda Shackley, Matilda Shackley, Yue Ma, Edward W. Tate, Alastair J. H. Brown, Gary Frost, Aylin C. Hanyaloglu

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Myristoylation profiling in human cells and zebrafish by Malgorzata Broncel, Remigiusz A Serwa, Paulina Ciepla, Eberhard Krause, Margaret J. Dallman, Anthony I. Magee, Edward W. Tate

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Structural basis for membrane attack complex inhibition by CD59 by Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck

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Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. by Daniel Paape, Andrew S Bell, William P Heal, Jennie A Hutton, Robin J Leatherbarrow, Edward W Tate, Deborah F Smith

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Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ by Dominic J. Pollard, Cedric N. Berger, Ernest C. So, Lu Yu, Kate Hadavizadeh, Patricia Jennings, Edward W. Tate, Jyoti S. Choudhary, Gad Frankel

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High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation by Cyril Dian, Inmaculada Pérez-Dorado, Frédéric Rivière, Thomas Asensio, Pierre Legrand, Markus Ritzefeld, Mengjie Shen, Ernesto Cota, Thierry Meinnel, Edward W. Tate, Carmela Giglione

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Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase by Thomas Lanyon-Hogg, Naoko Masumoto, George Bodakh, Antonio D. Konitsiotis, Emmanuelle Thinon, Ursula R. Rodgers, Raymond J. Owens, Anthony I. Magee, Edward W. Tate

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Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. by Andrew S Bell, James E Mills, Gareth P Williams, James A Brannigan, Anthony J Wilkinson, Tanya Parkinson, Robin J Leatherbarrow, Edward W Tate, Anthony A Holder, Deborah F Smith

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Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis by Goran Tomić, Clare Sheridan, Alice Y. Refermat, Marc P. Baggelaar, James Sipthorp, Bhuvana Sudarshan, Cory A. Ocasio, Alejandro Suárez-Bonnet, Simon L. Priestnall, Eleanor Herbert, Edward W. Tate, Julian Downward

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Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion. by Anja C Schlott, Ellen Knuepfer, Judith L Green, Philip Hobson, Aaron J Borg, Julia Morales-Sanfrutos, Abigail J Perrin, Catherine Maclachlan, Lucy M Collinson, Ambrosius P Snijders, Edward W Tate, Anthony A Holder

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Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration by Malgorzata Broncel, Caia Dominicus, Luis Vigetti, Stephanie D Nofal, Edward J Bartlett, Bastien Touquet, Alex Hunt, Bethan A Wallbank, Stefania Federico, Stephen Matthews, Joanna C Young, Edward W Tate, Isabelle Tardieux, Moritz Treeck

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Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion by Anja C. Schlott, Ellen Knuepfer, Judith L. Green, Philip Hobson, Aaron J. Borg, Julia Morales-Sanfrutos, Abigail J. Perrin, Catherine Maclachlan, Lucy M. Collinson, Ambrosius P. Snijders, Edward W. Tate, Anthony A. Holder

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Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite by Benoit Poulin, Eva-Maria Patzewitz, Declan Brady, Olivier Silvie, Megan H. Wright, David J. P. Ferguson, Richard J. Wall, Sarah Whipple, David S. Guttery, Edward W. Tate, Bill Wickstead, Anthony A. Holder, Rita Tewari

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A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein by Sabrina Yahiya, Charlie N. Saunders, Sarah Hassan, Ursula Straschil, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J. Delves, Edward W. Tate, Anna Barnard, Matthew J. Fuchter, Jake Baum

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Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia by Zhu Liang, Andreas Damianou, Iolanda Vendrell, Edward Jenkins, Frederik H. Lassen, Sam J. Washer, Athina Grigoriou, Guihai Liu, Gangshun Yi, Hantao Lou, Fangyuan Cao, Xiaonan Zheng, Ricardo A. Fernandes, Tao Dong, Edward W. Tate, Elena Di Daniel, Benedikt M. Kessler

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Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions by James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra

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Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis by Darian Williams, Marwa Mahmoud, Renfa Liu, Aitor Andueza, Sandeep Kumar, Dong-Won Kang, Jiahui Zhang, Ian Tamargo, Nicolas Villa-Roel, Kyung-In Baek, Hwakyoung Lee, Yongjin An, Leran Zhang, Edward W Tate, Pritha Bagchi, Jan Pohl, Laurent O Mosnier, Eleftherios P Diamandis, Koichiro Mihara, Morley D Hollenberg, Zhifei Dai, Hanjoong Jo

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Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins by Noura Alzahofi, Tobias Welz, Christopher L. Robinson, Emma L. Page, Deborah A. Briggs, Amy K. Stainthorp, James Reekes, David A. Elbe, Felix Straub, Wouter W. Kallemeijn, Edward W. Tate, Philip S. Goff, Elena V. Sviderskaya, Marta Cantero, Lluis Montoliu, Francois Nedelec, Amanda K. Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N. Hume

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