Letter to the Editor by Edwards Dr Iain G.

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Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloprote... by Kelwick, R, Wagstaff, L, Decock, J, Roghi, C, Cooley, L, Robinson, S, Arnold, H, Gavrilović, J, Jaworski, D, Yamamoto, K, Nagase, H, Seubert, B, Krüger, A, Edwards, DR

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. by Hennig, B, Velez-Edwards, DR, Schim van der Loeff, M, Bisseye, C, Edwards, T, Tacconelli, A, Novelli, G, Aaby, P, Kaye, S, Scott, W, Jaye, A, Whittle, H, Williams, S, Hill, A, Sirugo, G

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k). by Denton, C, Lindahl, G, Khan, K, Shiwen, X, Ong, V, Gaspar, N, Lazaridis, K, Edwards, DR, Leask, A, Eastwood, M, Leoni, P, Renzoni, E, Bou Gharios, G, Abraham, D, Black, C

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. by Kopitz, C, Gerg, M, Bandapalli, O, Ister, D, Pennington, C, Hauser, S, Flechsig, C, Krell, H, Antolovic, D, Brew, K, Nagase, H, Stangl, M, von Weyhern, C, Brücher, B, Brand, K, Coussens, L, Edwards, DR, Krüger, A

British society for matrix biology autumn meeting by Sudre, L, Cheung, F, Kevorkian, L, Young, D, Darrah, C, Donell, S, Shepstone, L, Porter, S, Brockbank, S, Edwards, DR, Parker, A, Clark, I, Boubriak, O, Urban, J, Cui, Z, Tew, SR, Li, Y, Tweats, L, Hawkins, R, Hardingham, T, Green, D, Partridge, K, Leveque, I, Mann, S, Oreffo, R

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis by Gallagher, CS, Mäkinen, N, Harris, HR, Rahmioglu, N, Uimari, O, Cook, JP, Shigesi, N, Ferreira, T, Velez-Edwards, DR, Edwards, TL, Mortlock, S, Ruhioglu, Z, Day, F, Becker, CM, Karhunen, V, Martikainen, H, Järvelin, M-R, Cantor, RM, Ridker, PM, Terry, KL, Buring, JE, Gordon, SD, Medland, SE, Montgomery, GW, Nyholt, DR

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. by Sapkota, Y, Steinthorsdottir, V, Morris, AP, Fassbender, A, Rahmioglu, N, De Vivo, I, Buring, JE, Zhang, F, Edwards, TL, Jones, S, O, D, Peterse, D, Rexrode, KM, Ridker, PM, Schork, AJ, MacGregor, S, Martin, NG, Becker, CM, Adachi, S, Yoshihara, K, Enomoto, T, Takahashi, A, Kamatani, Y, Matsuda, K, Kubo, M, Thorleifsson, G, Geirsson, RT, Thorsteinsdottir, U, Wallace, LM, iPSYCH-SSI-Broad Group, Yang, J, Edwards, DR, Nyegaard, M, Low, SK, Zondervan, KT, Missmer, SA, D'Hooghe, T, Montgomery, GW, Chasman, DI, Stefansson, K, Tung, JY, Nyholt, DR

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. by Eccles, SA, Aboagye, E, Ali, S, Anderson, A, Armes, J, Berditchevski, F, Blaydes, J, Brennan, K, Brown, N, Bryant, H, Bundred, N, Burchell, J, Campbell, A, Carroll, J, Clarke, R, Coles, C, Cook, G, Cox, A, Curtin, N, Dekker, L, Silva, I, Duffy, S, Easton, D, Eccles, D, Edwards, DR, Edwards, J, Evans, D, Fenlon, D, Flanagan, J, Foster, C, Gallagher, WM, Garcia-Closas, M, Gee, J, Gescher, A, Goh, V, Groves, A, Harvey, A, Harvie, M, Hennessy, B, Hiscox, S, Holen, I, Howell, S, Howell, A, Hubbard, G, Hulbert-Williams, N, Hunter, MS, Jasani, B, Jones, L, Key, T, Kirwan, C, Kong, A, Kunkler, I, Langdon, S, Leach, M, Mann, D, Marshall, J, Martin, L, Martin, S, Macdougall, J, Miles, D, Miller, W, Morris, JR, Moss, S, Mullan, P, Natrajan, R, O'Connor, J, O'Connor, R, Palmieri, C, Pharoah, P, Rakha, E, Reed, E, Robinson, S, Sahai, E, Saxton, J, Schmid, P, Smalley, M, Speirs, V, Stein, R, Stingl, J, Streuli, C, Tutt, A, Velikova, G, Walker, R, Watson, C, Williams, K, Young, L, Thompson, A

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals by Giri, A, Hellwege, JN, Keaton, JM, Park, J, Qiu, C, Warren, HR, Torstenson, ES, Kovesdy, CP, Sun, YV, Wilson, OD, Robinson-Cohen, C, Roumie, CL, Chung, CP, Birdwell, KA, Damrauer, SM, Duvall, SL, Klarin, D, Cho, K, Wang, Y, Evangelou, E, Cabrera, CP, Wain, LV, Shrestha, R, Mautz, BS, Akwo, EA, Sargurupremraj, M, Debette, S, Boehnke, M, Scott, LJ, Luan, J, Zhao, J-H, Willems, SM, Thériault, S, Shah, N, Oldmeadow, C, Almgren, P, Li-Gao, R, Verweij, N, Boutin, TS, Mangino, M, Ntalla, I, Feofanova, E, Surendran, P, Cook, JP, Karthikeyan, S, Lahrouchi, N, Liu, C, Sepúlveda, N, Richardson, TG, Kraja, A, Amouyel, P, Farrall, M, Poulter, NR, Understanding Society Scientific Group, International Consortium For Blood Pressure, Blood Pressure-International Consortium Of Exome Chip Studies, Laakso, M, Zeggini, E, Sever, P, Scott, RA, Langenberg, C, Wareham, NJ, Conen, D, Palmer, CNA, Attia, J, Chasman, DI, Ridker, PM, Melander, O, Mook-Kanamori, DO, Harst, PVD, Cucca, F, Schlessinger, D, Hayward, C, Spector, TD, Jarvelin, M-R, Hennig, BJ, Timpson, NJ, Wei, W-Q, Smith, JC, Xu, Y, Matheny, ME, Siew, EE, Lindgren, C, Herzig, K-H, Dedoussis, G, Denny, JC, Psaty, BM, Howson, JMM, Munroe, PB, Newton-Cheh, C, Caulfield, MJ, Elliott, P, Gaziano, JM, Concato, J, Wilson, PWF, Tsao, PS, Edwards, DR, Susztak, K, Million Veteran Program, O'Donnell, CJ, Hung, AM, Edwards, TL

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits by Evangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FL, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Edwards, DR, Sun, YV, Cho, K, Gaziano, JM, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Prins, BP, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S, Verweij, N, Willems, SM, Zhao, J-H, Amouyel, P, Connell, J, De Mutsert, R, Doney, ASF, Farrall, M, Menni, C, Morris, AD, Noordam, R, Paré, G, Poulter, NR, Shields, DC, Stanton, A, Thom, S, Abecasis, G, Amin, N, Arking, DE, Ayers, KL, Barbieri, CM, Batini, C, Bis, JC, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, DI, Bottinger, EP, Braund, PS, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, JC, Chauhan, G, Ciullo, M, Cocca, M, Collins, F, Cordell, HJ, Davies, G, Borst, MHD, Geus, EJD, Deary, IJ, Deelen, J, Del Greco M, F, Demirkale, CY, Dörr, M, Ehret, GB, Elosua, R, Enroth, S, Erzurumluoglu, AM, Ferreira, T, Frånberg, M, Franco, OH, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, AJ, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, TB, Harris, SE, Hartman, CA, Havulinna, AS, Hicks, AA, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, JE, Hwang, S-J, Ingelsson, E, James, A, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, AD, Joshi, PK, Jousilahti, P, Jukema, JW, Jula, A, Kähönen, M, Kathiresan, S, Keavney, BD, Khaw, K-T, Knekt, P, Knight, J, Kolcic, I, Kooner, JS, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, LJ, Lehne, B, Lehtimäki, T, Liewald, DCM, Lin, L, Lind, L, Lindgren, CM, Liu, Y, Loos, RJF, Lopez, LM, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, AP, Morrison, AC, Munson, PJ, Nalls, MA, Nandakumar, P, Nelson, CP, Niiranen, T, Nolte, IM, Nutile, T, Oldehinkel, AJ, Oostra, BA, O'Reilly, PF, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, BWJH, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Nguyen, QT, Raitakari, OT, Ren, M, Rettig, R, Rice, K, Ridker, PM, Ried, JS, Riese, H, Ripatti, S, Robino, A, Rose, LM, Rotter, JI, Rudan, I, Ruggiero, D, Saba, Y, Sala, CF, Salomaa, V, Samani, NJ, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, N, Siscovick, D, Smith, AV, Snieder, H, Sõber, S, Sorice, R, Starr, JM, Stott, DJ, Strachan, DP, Strawbridge, RJ, Sundström, J, Swertz, MA, Taylor, KD, Teumer, A, Tobin, MD, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, AG, Vaez, A, Van Der Most, PJ, Van Duijn, CM, Vergnaud, A-C, Verwoert, GC, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, SH, Willemsen, G, Wilson, JF, Wright, AF, Yao, J, Zemunik, T, Zhang, W, Attia, JR, Butterworth, AS, Chasman, DI, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, JMM, Laakso, M, Lakatta, EG, Langenberg, C, Melander, O, Mook-Kanamori, DO, Palmer, CNA, Risch, L, Scott, RA, Scott, RJ, Sever, P, Spector, TD, Van Der Harst, P, Wareham, NJ, Zeggini, E, Levy, D, Munroe, PB, Newton-Cheh, C, Brown, MJ, Metspalu, A, Hung, AM, O'Donnell, CJ, Edwards, TL, Million Veteran Program, Psaty, BM, Tzoulaki, I, Barnes, MR, Wain, LV, Elliott, P, Caulfield, MJ

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity by Turcot, V, Lu, Y, Highland, HM, Schurmann, C, Justice, AE, Fine, RS, Bradfield, JP, Esko, T, Giri, A, Graff, M, Guo, X, Hendricks, AE, Karaderi, T, Lempradl, A, Locke, AE, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, KL, Alfred, T, Feitosa, MF, Masca, NGD, Manning, AK, Medina-Gomez, C, Mudgal, P, Ng, MCY, Reiner, AP, Vedantam, S, Willems, SM, Winkler, TW, Abecasis, G, Aben, KK, Alam, DS, Alharthi, SE, Allison, M, Amouyel, P, Asselbergs, FW, Auer, PL, Balkau, B, Bang, LE, Barroso, I, Bastarache, L, Benn, M, Bergmann, S, Bielak, LF, Blüher, M, Boehnke, M, Boeing, H, Boerwinkle, E, Böger, CA, Bork-Jensen, J, Bots, ML, Bottinger, EP, Bowden, DW, Brandslund, I, Breen, G, Brilliant, MH, Broer, L, Brumat, M, Burt, AA, Butterworth, AS, Campbell, PT, Cappellani, S, Carey, DJ, Catamo, E, Caulfield, MJ, Chambers, JC, Chasman, DI, Chen, Y-DI, Chowdhury, R, Christensen, C, Chu, AY, Cocca, M, Collins, FS, Cook, JP, Corley, J, Galbany, J, Cox, AJ, Crosslin, DS, Cuellar-Partida, G, D'Eustacchio, A, Danesh, J, Davies, G, Bakker, PIW, Groot, MCH, Mutsert, R, Deary, IJ, Dedoussis, G, Demerath, EW, Heijer, M, Hollander, AI, Ruijter, HM, Dennis, JG, Denny, JC, Angelantonio, E, Drenos, F, Du, M, Dubé, M-P, Dunning, AM, Easton, DF, Edwards, TL, Ellinghaus, D, Ellinor, PT, Elliott, P, Evangelou, E, Farmaki, A-E, Farooqi, IS, Faul, JD, Fauser, S, Feng, S, Ferrannini, E, Ferrieres, J, Florez, JC, Ford, I, Fornage, M, Franco, OH, Franke, A, Franks, PW, Friedrich, N, Frikke-Schmidt, R, Galesloot, TE, Gan, W, Gandin, I, Gasparini, P, Gibson, J, Giedraitis, V, Gjesing, AP, Gordon-Larsen, P, Gorski, M, Grabe, H-J, Grant, SFA, Grarup, N, Griffiths, HL, Grove, ML, Gudnason, V, Gustafsson, S, Haessler, J, Hakonarson, H, Hammerschlag, AR, Hansen, T, Harris, KM, Harris, TB, Hattersley, AT, Have, CT, Hayward, C, He, L, Heard-Costa, NL, Heath, AC, Heid, IM, Helgeland, Ø, Hernesniemi, J, Hewitt, AW, Holmen, OL, Hovingh, GK, Howson, JMM, Hu, Y, Huang, PL, Huffman, JE, Ikram, MA, Ingelsson, E, Jackson, AU, Jansson, J-H, Jarvik, GP, Jensen, GB, Jia, Y, Johansson, S, Jørgensen, ME, Jørgensen, T, Jukema, JW, Kahali, B, Kahn, RS, Kähönen, M, Kamstrup, PR, Kanoni, S, Kaprio, J, Karaleftheri, M, Kardia, SLR, Karpe, F, Kathiresan, S, Kee, F, Kiemeney, LA, Kim, E, Kitajima, H, Komulainen, P, Kooner, JS, Kooperberg, C, Korhonen, T, Kovacs, P, Kuivaniemi, H, Kutalik, Z, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, TA, Lamparter, D, Lange, EM, Lange, LA, Langenberg, C, Larson, EB, Lee, NR, Lehtimäki, T, Lewis, CE, Li, H, Li, J, Li-Gao, R, Lin, H, Lin, K-H, Lin, L-A, Lin, X, Lind, L, Lindström, J, Linneberg, A, Liu, C-T, Liu, DJ, Liu, Y, Lo, KS, Lophatananon, A, Lotery, AJ, Loukola, A, Luan, J, Lubitz, SA, Lyytikäinen, L-P, Männistö, S, Marenne, G, Mazul, AL, McCarthy, MI, McKean-Cowdin, R, Medland, SE, Meidtner, K, Milani, L, Mistry, V, Mitchell, P, Mohlke, KL, Moilanen, L, Moitry, M, Montgomery, GW, Mook-Kanamori, DO, Moore, C, Mori, TA, Morris, AD, Morris, AP, Müller-Nurasyid, M, Munroe, PB, Nalls, MA, Narisu, N, Nelson, CP, Neville, M, Nielsen, SF, Nikus, K, Njølstad, PR, Nordestgaard, BG, Nyholt, DR, O'Connel, JR, O'Donoghue, ML, Loohuis, LM, Ophoff, RA, Owen, KR, Packard, CJ, Padmanabhan, S, Palmer, CNA, Palmer, ND, Pasterkamp, G, Patel, AP, Pattie, A, Pedersen, O, Peissig, PL, Peloso, GM, Pennell, CE, Perola, M, Perry, JA, Perry, JRB, Pers, TH, Person, TN, Peters, A, Petersen, ERB, Peyser, PA, Pirie, A, Polasek, O, Polderman, TJ, Puolijoki, H, Raitakari, OT, Rasheed, A, Rauramaa, R, Reilly, DF, Renström, F, Rheinberger, M, Ridker, PM, Rioux, JD, Rivas, MA, Roberts, DJ, Robertson, NR, Robino, A, Rolandsson, O, Rudan, I, Ruth, KS, Saleheen, D, Salomaa, V, Samani, NJ, Sapkota, Y, Sattar, N, Schoen, RE, Schreiner, PJ, Schulze, MB, Scott, RA, Segura-Lepe, MP, Shah, SH, Sheu, WH-H, Sim, X, Slater, AJ, Small, KS, Smith, AV, Southam, L, Spector, TD, Speliotes, EK, Starr, JM, Stefansson, K, Steinthorsdottir, V, Stirrups, KE, Strauch, K, Stringham, HM, Stumvoll, M, Sun, L, Surendran, P, Swift, AJ, Tada, H, Tansey, KE, Tardif, J-C, Taylor, KD, Teumer, A, Thompson, DJ, Thorleifsson, G, Thorsteinsdottir, U, Thuesen, BH, Tönjes, A, Tromp, G, Trompet, S, Tsafantakis, E, Tuomilehto, J, Tybjaerg-Hansen, A, Tyrer, JP, Uher, R, Uitterlinden, AG, Uusitupa, M, Laan, SW, Duijn, CM, Leeuwen, N, van Setten, J, Vanhala, M, Varbo, A, Varga, TV, Varma, R, Edwards, DR, Vermeulen, SH, Veronesi, G, Vestergaard, H, Vitart, V, Vogt, TF, Völker, U, Vuckovic, D, Wagenknecht, LE, Walker, M, Wallentin, L, Wang, F, Wang, CA, Wang, S, Wang, Y, Ware, EB, Wareham, NJ, Warren, HR, Waterworth, DM, Wessel, J, White, HD, Willer, CJ, Wilson, JG, Witte, DR, Wood, AR, Wu, Y, Yaghootkar, H, Yao, J, Yao, P, Yerges-Armstrong, LM, Young, R, Zeggini, E, Zhan, X, Zhang, W, Zhao, JH, Zhao, W, Zhou, W, Zondervan, KT, Rotter, JI, Pospisilik, JA, Rivadeneira, F, Borecki, IB, Deloukas, P, Frayling, TM, Lettre, G, North, KE, Lindgren, CM, Hirschhorn, JN, Loos, RJF