AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance by Caroline R.M. Wiggers, Mirna L. Baak, Edwin Sonneveld, Edward E.S. Nieuwenhuis, Marije Bartels, Menno P. Creyghton

Get full text

Integrating copy number data of 64 iAMP21 BCP-ALL patients narrows the common region of amplification to 1.57 Mb by Femke M. Hormann, Femke M. Hormann, Femke M. Hormann, Alex Q. Hoogkamer, Alex Q. Hoogkamer, Aurélie Boeree, Aurélie Boeree, Edwin Sonneveld, Edwin Sonneveld, Gabriele Escherich, Gabriele Escherich, Monique L. den Boer, Monique L. den Boer, Monique L. den Boer, Monique L. den Boer, Judith M. Boer, Judith M. Boer

Get full text

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia by Anna Wojtuszkiewicz, Yehuda G. Assaraf, Mirthe Hoekstra, Rocco Sciarrillo, Gerrit Jansen, Godefridus J. Peters, Rob Pieters, Edwin Sonneveld, Gabriele Escherich, Gertjan J.L. Kaspers, Jacqueline Cloos

Get full text

Secondary lesions and sensitivity to signaling inhibitors in iAMP21 acute lymphoblastic leukemia by Femke M. Hormann, Anna Østergaard, Stijn van denBroek, Aurélie Boeree, Cesca van deVen, Gabriele Escherich, Edwin Sonneveld, Judith M. Boer, Monique L. den Boer

Get full text

P366: ARE MINIMAL RESIDUAL DISEASE MEASUREMENTS AFTER CONSOLIDATION THERAPY USEFUL IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA? by Janine Stutterheim, Rachella Van der Waarden, Hester de Groot-Kruseman, Edwin Sonneveld, Valerie De Haas, Ellen C Van der Schoot, Vincent van der Velden, Rana Dandis, Rob Pieters

Get full text

Targeted treatment options for paediatric B-cell precursor acute lymphoblastic leukaemia patients with constitutional or somatic chromosome 21 alterations by Naomi Michels, Femke M. Hormann, Aurélie Boeree, Edwin Sonneveld, Anthony V. Moorman, Gabriele Escherich, Rosemary Sutton, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer, Judith M. Boer

Get full text

The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution. by Esmé Waanders, Blanca Scheijen, Laurens T van der Meer, Simon V van Reijmersdal, Liesbeth van Emst, Yvet Kroeze, Edwin Sonneveld, Peter M Hoogerbrugge, Ad Geurts van Kessel, Frank N van Leeuwen, Roland P Kuiper

Get full text

Molecular Measurable Residual Disease Assessment before Hematopoietic Stem Cell Transplantation in Pediatric Acute Myeloid Leukemia Patients: A Retrospective Study by the I-BFM Stu... by Maddalena Benetton, Pietro Merli, Christiane Walter, Maria Hansen, Ambra Da Ros, Katia Polato, Claudia Tregnago, Jonas Abrahamsson, Luisa Strocchio, Edwin Sonneveld, Linda Fogelstrand, Nils Von Neuhoff, Dirk Reinhardt, Henrik Hasle, Martina Pigazzi, Franco Locatelli

Get full text

Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia by Jasmijn D.E. de Rooij, Eva Beuling, Marry M. van den Heuvel-Eibrink, Askar Obulkasim, André Baruchel, Jan Trka, Dirk Reinhardt, Edwin Sonneveld, Brenda E.S. Gibson, Rob Pieters, Martin Zimmermann, C. Michel Zwaan, Maarten Fornerod

Get full text

ABL-class Genomic Breakpoint Q-PCR: A Patient-specific Approach for MRD Monitoring in Acute Lymphoblastic Leukemia by Inge van Outersterp, Vincent H.J. van der Velden, Patricia G. Hoogeveen, Goda E. Vaitkevičienė, Edwin Sonneveld, Gijs van Haaften, Roland P. Kuiper, Udo zur Stadt, Gabriele Escherich, Judith M. Boer, Monique L. den Boer

Get full text

Upfront Treatment Influences the Composition of Genetic Alterations in Relapsed Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia by Jiangyan Yu, Esmé Waanders, Simon V. van Reijmersdal, Željko Antić, Charlotte M. van Bosbeek, Edwin Sonneveld, Hester de Groot, Marta Fiocco, Ad Geurts van Kessel, Frank N. van Leeuwen, Rob Pieters, Peter M. Hoogerbrugge, Roland P. Kuiper

Get full text

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations by Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper

Get full text

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia by Linda Zuurbier, Emanuel F. Petricoin, Maartje J. Vuerhard, Valerie Calvert, Clarissa Kooi, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Edwin Sonneveld, Anjo J.P. Veerman, Willem A. Kamps, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink

Get full text

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors by Linda Zuurbier, Alejandro Gutierrez, Charles G. Mullighan, Kirsten Canté-Barrett, A. Olivier Gevaert, Johan de Rooi, Yunlei Li, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Edwin Sonneveld, A. Thomas Look, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink

Get full text

NOTCH1 fusions in pediatric T‐cell lymphoblastic lymphoma: A high‐risk subgroup with CCL17 (TARC) levels as diagnostic biomarker by Emma Kroeze, Michelle M. Kleisman, Lennart A. Kester, Marijn A. Scheijde‐Vermeulen, Edwin Sonneveld, Jessica G. C. Buijs‐Gladdines, Melanie M. Hagleitner, Friederike A. G. Meyer‐Wentrup, Margreet A. Veening, Auke Beishuizen, Jules P. P. Meijerink, Jan L. C. Loeffen, Roland P. Kuiper

Get full text

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients by Blanca Scheijen, Judith M. Boer, René Marke, Esther Tijchon, Dorette van Ingen Schenau, Esmé Waanders, Liesbeth van Emst, Laurens T. van der Meer, Rob Pieters, Gabriele Escherich, Martin A. Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P. Kuiper, Peter M. Hoogerbrugge, Monique L. den Boer, Frank N. van Leeuwen

Get full text

Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia by Iris H.I.M. Hollink, Marry M. van den Heuvel-Eibrink, Susan T.C.J.M. Arentsen-Peters, Martin Zimmermann, Justine K. Peeters, Peter J.M. Valk, Brian V. Balgobind, Edwin Sonneveld, Gertjan J.L. Kaspers, Eveline S.J.M. de Bont, Jan Trka, Andre Baruchel, Ursula Creutzig, Rob Pieters, Dirk Reinhardt, C. Michel Zwaan

Get full text

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement by Simon Bomken, Amir Enshaei, Edward C. Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent T.M. Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, G.A. Amos Burke, Giovanni Cazzaniga, Gudrun Gohring, Hesta A. de Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent H.J. van der Velden, Vikki Rand, Stephen P. Hunger, Christine J. Harrison, Chris M. Bacon, Frederik W. van Delft, Mignon L. Loh, John Moppett, Josef Vormoor, Brian A. Walker, Anthony V. Moorman, Lisa J. Russell

Get full text

Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study by Sergio Matarraz, Pilar Leoz, Ana Yeguas-Bermejo, Vincent van der Velden, Anne E. Bras, Jose I. Sánchez Gallego, Quentin Lecrevisse, Rosa Ayala-Bueno, Cristina Teodosio, Ignacio Criado, María González-González, Juan Flores-Montero, Alejandro Avendaño, María B. Vidriales, María C. Chillón, Teresa González, Ramón García-Sanz, María I. Prieto Conde, Neus Villamor, Laura Magnano, Enrique Colado, Paula Fernández, Edwin Sonneveld, Jan Philippé, Michaela Reiterová, Juan C. Caballero Berrocal, Francisco J. Diaz-Gálvez, Fernando Ramos, Julio Dávila Valls, Raquel Manjón Sánchez, Jackeline Solano Tovar, Xavier Calvo, Luis García Alonso, Leonor Arenillas, Sara Alonso, Ariana Fonseca, Covadonga Quirós Caso, Jacques J. M. van Dongen, Alberto Orfao

Get full text