Active site CP-loop dynamics modulate substrate binding, catalysis, oligomerization, stability, over-oxidation and recycling of 2-Cys Peroxiredoxins by Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard

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Essential role of the flexible linker on the conformational equilibrium of bacterial peroxiredoxin reductase for effective regeneration of peroxiredoxin by Grüber, Gerhard, Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank

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Molecular mechanism of the Escherichia coli AhpC in the function of a chaperone under heat-shock conditions by Kamariah, Neelagandan, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard

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Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding t... by Su, Chinh Tran-To, Sinha, Swati, Eisenhaber, Birgit, Eisenhaber, Frank

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On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation by Wong, Wing-Cheong, Maurer-Stroh, Sebastian, Eisenhaber, Birgit, Eisenhaber, Frank

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The first quarter century of the dense alignment surface transmembrane prediction method by Cserző, Miklós, Eisenhaber, Birgit, Eisenhaber, Frank, Magyar, Csaba, Simon, István

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dissectHMMER: a HMMER-based score dissection framework that statistically evaluates fold-critical sequence segments for domain fold similarity by Wong, Wing-Cheong, Yap, Choon-Kong, Eisenhaber, Birgit, Eisenhaber, Frank

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xHMMER3x2: Utilizing HMMER3’s speed and HMMER2’s sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotation by Yap, Choon-Kong, Eisenhaber, Birgit, Eisenhaber, Frank, Wong, Wing-Cheong

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About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature by Tantoso, Erwin, Eisenhaber, Birgit, Sinha, Swati, Jensen, Lars Juhl, Eisenhaber, Frank

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Did the early full genome sequencing of yeast boost gene function discovery? by Tantoso, Erwin, Eisenhaber, Birgit, Sinha, Swati, Jensen, Lars Juhl, Eisenhaber, Frank

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Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins by Kamariah, Neelagandan, Sek, Mun Foong, Eisenhaber, Birgit, Eisenhaber, Frank, Grüber, Gerhard

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Darkness in the human gene and protein function space : widely modest or absent illumination by the life science literature and the trend for fewer protein function discoveries sin... by Sinha, Swati, Eisenhaber, Birgit, Jensen, Lars Juhl, Kalbuaji, Bharata, Eisenhaber, Frank

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Functional classification of super-large families of enzymes based on substrate binding pocket residues for biocatalysis and enzyme engineering applications by Sirota, Fernanda L., Maurer-Stroh, Sebastian, Li, Zhi, Eisenhaber, Frank, Eisenhaber, Birgit

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Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule” by Baker, James Alexander, Wong, Wing-Cheong, Eisenhaber, Birgit, Warwicker, Jim, Eisenhaber, Frank

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Beware of moving tagerts: reference proteome content fluctuates substantially over the years by Sirota, Fernanda L., Batagov, Arsen, Schneider, Georg, Eisenhaber, Birgit, Eisenhaber, Frank, Maurer-Stroh, Sebastian

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Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C ass... by Toh, Yew Kwang, Shin, Joon, Balakrishna, Asha Manikkoth, Kamariah, Neelagandan, Grüber, Ardina, Eisenhaber, Frank, Eisenhaber, Birgit, Grüber, Gerhard

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Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites by Eisenhaber, Birgit, Sinha, Swati, Jadalanki, Chaitanya K., Shitov, Vladimir A., Tan, Qiao Wen, Sirota, Fernanda L., Eisenhaber, Frank

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Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723 by Sinha, Swati, Nge, Choy-Eng, Leong, Chung Yan, Ng, Veronica, Crasta, Sharon, Goh, Falicia, Low, Kia-Ngee, Zhang, Huibin, Arumugam, Prakash, Lezhava, Alexander, Chen, Swaine L., Kanagasundaram, Yoganathan, Ng, Siew Bee, Eisenhaber, Frank, Eisenhaber, Birgit, Mohammad Alfatah

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Identification and engineering of 32 membered antifungal macrolactone notonesomycins by Goh, Falicia, Zhang, Mingzi M., Lim, Tian Ru, Low, Kia Ngee, Nge, Choy Eng, Heng, Elena, Yeo, Wan Lin, Sirota, Fernanda L., Crasta, Sharon, Tan, Zann, Ng, Veronica, Leong, Chung Yan, Zhang, Huibin, Lezhava, Alexander, Chen, Swaine L., Hoon, Shawn S., Eisenhaber, Frank, Eisenhaber, Birgit, Kanagasundaram, Yoganathan, Wong, Fong T., Ng, Siew Bee

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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer by Mishra, Alok K., Ye, Tianyi, Banday, Shahid, Thakare, Ritesh P., Su, Chinh Tran-To, Pham, Ngoc N. H., Ali, Amjad, Kulshreshtha, Ankur, Chowdhury, Shreya Roy, Simone, Tessa M., Hu, Kai, Zhu, Lihua Julie, Eisenhaber, Birgit, Deibler, Sara K., Simin, Karl, Thompson, Paul R., Kelliher, Michelle A., Eisenhaber, Frank, Malonia, Sunil K., Green, Michael R.

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