Double Strike Approach for Tumor Attack: Engineering T Cells Using a CD40L:CD28 Chimeric Co-Stimulatory Switch Protein for Enhanced Tumor Targeting in Adoptive Cell Therapy by Luis Felipe Olguín-Contreras, Anna N. Mendler, Grzegorz Popowicz, Bin Hu, Elfriede Noessner, Elfriede Noessner

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A Lysine Residue at the C-Terminus of MHC Class I Ligands Correlates with Low C-Terminal Proteasomal Cleavage Probability by Adrian Schmalen, Ilona E. Kammerl, Silke Meiners, Elfriede Noessner, Cornelia A. Deeg, Stefanie M. Hauck

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614 Co-stimulation via PD1–41BB chimeric switch receptor enhances function of TCR-T cells in an immune-suppressive milieu and under chronic antigen stimulation by Elfriede Noessner, Daniel Sommermeyer, Christian Ellinger, Nadja Sailer, Melanie Salvermoser, Maria Gerget, Franziska Hasselmann, Monika Braun

Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing by Angelika J. Fischbeck, Svenja Ruehland, Svenja Ruehland, Andreas Ettinger, Kerstin Paetzold, Ilias Masouris, Elfriede Noessner, Anna N. Mendler

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Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses. by Susanne Harner, Elfriede Noessner, Korinna Nadas, Anke Leumann-Runge, Matthias Schiemann, Fabienne L Faber, Joachim Heinrich, Susanne Krauss-Etschmann

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Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. by Roghieh Djafarzadeh, Matthias Sauter, Susan Notohamiprodjo, Elfriede Noessner, Pankaj Goyal, Wolfgang Siess, Markus Wörnle, Andrea Ribeiro, Susanne Himmelein, Thomas Sitter, Peter J Nelson

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Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival by Dorothee Brech, Anna S. Herbstritt, Sarah Diederich, Tobias Straub, Evangelos Kokolakis, Martin Irmler, Johannes Beckers, Florian A. Büttner, Elke Schaeffeler, Stefan Winter, Matthias Schwab, Peter J. Nelson, Elfriede Noessner

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Vγ9Vδ2 T Cells Concurrently Kill Cancer Cells and Cross-Present Tumor Antigens by Gitte Holmen Olofsson, Manja Idorn, Manja Idorn, Ana Micaela Carnaz Simões, Pia Aehnlich, Signe Koggersbøl Skadborg, Elfriede Noessner, Reno Debets, Bernhard Moser, Özcan Met, Özcan Met, Per thor Straten, Per thor Straten

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Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. by Henrik Gross, Christine Hennard, Ilias Masouris, Christian Cassel, Stephanie Barth, Ute Stober-Grässer, Alfredo Mamiani, Bodo Moritz, Dirk Ostareck, Antje Ostareck-Lederer, Nils Neuenkirchen, Utz Fischer, Wen Deng, Heinrich Leonhardt, Elfriede Noessner, Elisabeth Kremmer, Friedrich A Grässer

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Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function by Hendrik Gassmann, Kira Schneider, Valentina Evdokimova, Peter Ruzanov, Sebastian J. Schober, Busheng Xue, Kristina von Heyking, Melanie Thiede, Guenther H. S. Richter, Michael W. Pfaffl, Elfriede Noessner, Lincoln D. Stein, Poul H. Sorensen, Stefan E. G. Burdach, Uwe Thiel

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CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity by Madhura Modak, Ann-Kathrin Mattes, Daniela Reiss, Wioletta Skronska-Wasek, Rebecca Langlois, Nicolas Sabarth, Renate Konopitzky, Fidel Ramirez, Katharina Lehr, Tobias Mayr, David Kind, Coralie Viollet, Lee Kim Swee, Jutta Petschenka, Karim C. El Kasmi, Elfriede Noessner, Kerstin Kitt, Stefan Pflanz

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Collagen density regulates the activity of tumor-infiltrating T cells by Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen

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Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma – a case report by Rolf D. Issels, Lars H. Lindner, Michael von Bergwelt-Baildon, Peter Lang, Christoph Rischpler, Heinz Diem, Barbara Mosetter, Judith Eckl, Dolores J. Schendel, Christoph Salat, Oliver Stötzer, Stefan Burdach, Irene von Luettichau-Teichert, Rupert Handgretinger, Jens Neumann, Thomas Kirchner, Katja Steiger, Melanie Boxberg, Ulrich Mansmann, Gabriele Multhoff, Elfriede Noessner

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Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities by Chang-Feng Chu, Chang-Feng Chu, Chang-Feng Chu, Florian Sabath, Silvia Fibi-Smetana, Shan Sun, Shan Sun, Rupert Öllinger, Elfriede Noeßner, Ying-Yin Chao, Ying-Yin Chao, Linus Rinke, Elena Winheim, Roland Rad, Anne B. Krug, Leila Taher, Christina E. Zielinski, Christina E. Zielinski, Christina E. Zielinski

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Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes by Anna Esteve-Codina, Thomas P. Hofer, Dorothe Burggraf, Marion S. Heiss-Neumann, Wolfgang Gesierich, Anne Boland, Robert Olaso, Marie-Therese Bihoreau, Jean-Francois Deleuze, Winfried Moeller, Otmar Schmid, María Soler Artigas, Kathrin Renner, Jens M. Hohlfeld, Tobias Welte, Thomas Fuehner, Lukas Jerrentrup, Andreas Rembert Koczulla, Timm Greulich, Antje Prasse, Joachim Müller-Quernheim, Sumit Gupta, Christopher Brightling, Deepak R. Subramanian, David G. Parr, Umme Kolsum, Vandana Gupta, Imre Barta, Balázs Döme, János Strausz, Mariarita Stendardo, Marco Piattella, Piera Boschetto, Damian Korzybski, Dorota Gorecka, Adam Nowinski, Marc Dabad, Marcos Fernández-Callejo, David Endesfelder, Wolfgang zu Castell, Pieter S. Hiemstra, Per Venge, Elfriede Noessner, Thasso Griebel, Simon Heath, Dave Singh, Ivo Gut, Loems Ziegler-Heitbrock

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