Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene by Andriana G Kotini, Elisa de Stanchina, Maria Themeli, Michel Sadelain, Eirini P Papapetrou

Get full text

Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype. by Alan L Ho, Elgilda Musi, Grazia Ambrosini, Jayasree S Nair, Shyamprasad Deraje Vasudeva, Elisa de Stanchina, Gary K Schwartz

Get full text

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma by Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel

Get full text

Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma by Alan W Long, Hong Xu, Brian H Santich, Hongfen Guo, Sayed Shahabuddin Hoseini, Elisa de Stanchina, Nai-Kong V Cheung

Get full text

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor by James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm

Get full text

Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer by Ellinor I. Peerschke, Elisa de Stanchina, Qing Chang, Katia Manova-Todorova, Afsar Barlas, Anne G. Savitt, Brian V. Geisbrecht, Berhane Ghebrehiwet

Get full text

Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis by Shanshan Duan, Loredana Moro, Rui Qu, Daniele Simoneschi, Hyunwoo Cho, Shaowen Jiang, Huiyong Zhao, Qing Chang, Elisa de Stanchina, Arnaldo A. Arbini, Michele Pagano

Get full text

Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells by Nayanendu Saha, Kai Xu, Zhongyu Zhu, Dorothea Robev, Teja Kalidindi, Yan Xu, Juha Himanen, Elisa de Stanchina, Naga Vara Kishore Pillarsetty, Dimiter S Dimitrov, Dimitar B Nikolov

Get full text

S104: DIFFERENTIAL TARGET PROFILES AND EFFICACY OF ADCLEC.SYN1 AND CD33-CARS IN HUMANIZED AML MODELS by Sascha Haubner, Jorge Mansilla-Soto, Sarah Nataraj, Friederike Kogel, Qing Chang, Elisa de Stanchina, Michael Lopez, Kathryn Fraser, Jae Park, Xiuyan Wang, Isabelle Rivière, Michel Sadelain

Get full text

Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors by Maria E. R. Garcia-Rendueles, Gnana Krishnamoorthy, Mahesh Saqcena, Adrian Acuña-Ruiz, Giovanna Revilla, Elisa de Stanchina, Jeffrey A. Knauf, Rona Lester, Bin Xu, Ronald A. Ghossein, James A. Fagin

Get full text

Peptidomimetic blockade of MYB in acute myeloid leukemia by Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis

Get full text

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis by Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie

Get full text

CryoPause: A New Method to Immediately Initiate Experiments after Cryopreservation of Pluripotent Stem Cells by Karen G. Wong, Sean D. Ryan, Kiran Ramnarine, Siera A. Rosen, Shannon E. Mann, Amanda Kulick, Elisa De Stanchina, Franz-Josef Müller, Thadeous J. Kacmarczyk, Chao Zhang, Doron Betel, Mark J. Tomishima

Get full text

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors by Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare

Get full text

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer by Jennifer C. Villa, Danica Chiu, Alissa H. Brandes, Freddy E. Escorcia, Carlos H. Villa, William F. Maguire, Cheng-Jun Hu, Elisa de Stanchina, M. Celeste Simon, Sangram S. Sisodia, David A. Scheinberg, Yue-Ming Li

Get full text

TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models by Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens

Get full text

HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway by Alison E. Smith, Emanuela Ferraro, Anton Safonov, Cristina Bernado Morales, Enrique J. Arenas Lahuerta, Qing Li, Amanda Kulick, Dara Ross, David B. Solit, Elisa de Stanchina, Jorge Reis-Filho, Neal Rosen, Joaquín Arribas, Pedram Razavi, Sarat Chandarlapaty

Get full text

Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing by Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin

Get full text

SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing by Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin

Get full text

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers by Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles Sawyers, Neal Rosen, Andrew C. Hsieh, Yu Chen, Brett S. Carver

Get full text