Messenger RNA vaccines for cancer immunotherapy: progress promotes promise by Amanda L. Huff, Elizabeth M. Jaffee, Neeha Zaidi

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Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors by Hanwen Wang, Richard J. Sové, Mohammad Jafarnejad, Sondra Rahmeh, Elizabeth M. Jaffee, Elizabeth M. Jaffee, Vered Stearns, Evanthia T. Roussos Torres, Roisin M. Connolly, Roisin M. Connolly, Aleksander S. Popel, Aleksander S. Popel

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Transcriptional profiling identifies novel regulators of macrophage polarization. by Kimberline Y Gerrick, Elias R Gerrick, Anuj Gupta, Sarah J Wheelan, Srinivasan Yegnasubramanian, Elizabeth M Jaffee

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Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer by Haoyang Mi, Chang Gong, Jeremias Sulam, Jeremias Sulam, Elana J. Fertig, Elana J. Fertig, Alexander S. Szalay, Alexander S. Szalay, Elizabeth M. Jaffee, Elizabeth M. Jaffee, Vered Stearns, Leisha A. Emens, Ashley M. Cimino-Mathews, Ashley M. Cimino-Mathews, Aleksander S. Popel, Aleksander S. Popel

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Pancreatic Ductal Adenocarcinoma Cortical Mechanics and Clinical Implications by Shantel Angstadt, Shantel Angstadt, Shantel Angstadt, Qingfeng Zhu, Elizabeth M. Jaffee, Douglas N. Robinson, Douglas N. Robinson, Robert A. Anders

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Colorectal cancer in patients of advanced age is associated with increased incidence of BRAF p.V600E mutation and mismatch repair deficiency by Eric S. Christenson, Eric S. Christenson, Hua-Ling Tsai, Hua-Ling Tsai, Dung T. Le, Dung T. Le, Elizabeth M. Jaffee, Elizabeth M. Jaffee, Jonathan Dudley, Jonathan Dudley, Rena R. Xian, Rena R. Xian, Christopher D. Gocke, Christopher D. Gocke, James R. Eshleman, James R. Eshleman, Ming-Tseh Lin

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Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells. by Vivian L Weiss, Timothy H Lee, Hong Song, Theodore S Kouo, Chelsea M Black, George Sgouros, Elizabeth M Jaffee, Todd D Armstrong

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Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer by May Tun Saung, Stephen Muth, Ding Ding, Dwayne L. Thomas, Alex B. Blair, Takahiro Tsujikawa, Lisa Coussens, Elizabeth M. Jaffee, Lei Zheng

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MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity. by Mark Yarchoan, Aditya A Mohan, Lauren Dennison, Teena Vithayathil, Amanda Ruggieri, Gregory B Lesinski, Todd D Armstrong, Nilofer S Azad, Elizabeth M Jaffee

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Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors by Emily F. Davis-Marcisak, Allison A. Fitzgerald, Michael D. Kessler, Ludmila Danilova, Elizabeth M. Jaffee, Neeha Zaidi, Louis M. Weiner, Elana J. Fertig

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Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide by Adam C. Mirando, Akash Patil, Christine I. Rafie, Brian J. Christmas, Niranjan B. Pandey, Vered Stearns, Elizabeth M. Jaffee, Evanthia T. Roussos Torres, Aleksander S. Popel

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Analysis of Population Differences in Digital Conversations About Cancer Clinical Trials: Advanced Data Mining and Extraction Study by Edith A Perez, Elizabeth M Jaffee, John Whyte, Cheryl A Boyce, John D Carpten, Guillermina Lozano, Raymond M Williams, Karen M Winkfield, David Bernstein, Sung Poblete

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Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR by Theresa L Walunas, Lisa H Butterfield, William J Murphy, Elizabeth M Jaffee, Bart O Roep, Nicholas L Bayless, Jeffrey A Bluestone, Samantha Bucktrout, Christian A Koch, Arlene H Sharpe

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Solid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer by Eric S. Christenson, Valerie Lee, Hao Wang, Mark Yarchoan, Ana De Jesus-Acosta, Nilo Azad, Ahmet Gurakar, Ming-Tseh Lin, Dung T. Le, Daniel C. Brennan, Elizabeth M. Jaffee, Katherine Bever

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Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence by Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara

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Integrated T cell cytometry metrics for immune-monitoring applications in immunotherapy clinical trials by Dimitrios N. Sidiropoulos, Genevieve L. Stein-O’Brien, Ludmila Danilova, Nicole E. Gross, Soren Charmsaz, Stephanie Xavier, James Leatherman, Hao Wang, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Won Jin Ho

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Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies by Victoria M. Kim, Alex B. Blair, Peter Lauer, Kelly Foley, Xu Che, Kevin Soares, Tao Xia, Stephen T. Muth, Jennifer Kleponis, Todd D. Armstrong, Christopher L. Wolfgang, Elizabeth M. Jaffee, Dirk Brockstedt, Lei Zheng

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Barcoding intracellular reverse transcription enables high-throughput phenotype-coupled T cell receptor analyses by Sahana Jayaraman, Janelle M. Montagne, Thomas R. Nirschl, Emily Marcisak, Jeanette Johnson, Amanda Huff, Meng-Hsuan Hsiao, Julie Nauroth, Thatcher Heumann, Jelani C. Zarif, Elizabeth M. Jaffee, Nilo Azad, Elana J. Fertig, Neeha Zaidi, H. Benjamin Larman

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641 A pilot study of a DNAJB1-PRKACA fusion kinase peptide vaccine combined with nivolumab and ipilimumab for patients with fibrolamellar hepatocellular carcinoma by Hao Wang, Paul Thomas, Elizabeth M Jaffee, Mark Yarchoan, Jennifer Durham, Brian Ladle, Alex Thompson, Madalena Brancati, Christopher Thoburn, Zeal Kamdar, Marina Baretti, Julie Nauroth, Anna Ferguson, Paige Griffith, Allison Kirk, Neeha Zaidi, Amanda Huff, Won Ho, Mark Furth

Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways by Won Jin Ho, Rossin Erbe, Ludmila Danilova, Zaw Phyo, Emma Bigelow, Genevieve Stein-O’Brien, Dwayne L. Thomas, Soren Charmsaz, Nicole Gross, Skylar Woolman, Kayla Cruz, Rebecca M. Munday, Neeha Zaidi, Todd D. Armstrong, Marcelo B. Sztein, Mark Yarchoan, Elizabeth D. Thompson, Elizabeth M. Jaffee, Elana J. Fertig

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