The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy by David F. Ackerley, Janine N. Copp, Laura K. Green, Mathew A. Storey, Elsie M. Williams, Jeff B. Smaill, Adam V. Patterson

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Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications by Amir Ashoorzadeh, Alexandra M. Mowday, Christopher P. Guise, Shevan Silva, Matthew R. Bull, Maria R. Abbattista, Janine N. Copp, Elsie M. Williams, David F. Ackerley, Adam V. Patterson, Jeff B. Smaill

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Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues by Kelsi R Hall, Katherine J Robins, Elsie M Williams, Michelle H Rich, Mark J Calcott, Janine N Copp, Rory F Little, Ralf Schwörer, Gary B Evans, Wayne M Patrick, David F Ackerley

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Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections by Janine N. Copp, Daniel Pletzer, Alistair S. Brown, Joris Van der Heijden, Charlotte M. Miton, Rebecca J. Edgar, Michelle H. Rich, Rory F. Little, Elsie M. Williams, Robert E. W. Hancock, Nobuhiko Tokuriki, David F. Ackerley

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