Editorial: Machine learning, epistasis, and protein engineering: From sequence-structure-function relationships to regulation of metabolic pathways by Frederic Cadet, Frederic Cadet, Emma Saavedra, Per-Olof Syren, Per-Olof Syren, Brigitte Gontero

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The contribution of two isozymes to the pyruvate kinase activity of Vibrio cholerae: One K+-dependent constitutively active and another K+-independent with essential allosteric act... by Carlos Guerrero-Mendiola, José J García-Trejo, Rusely Encalada, Emma Saavedra, Leticia Ramírez-Silva

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Inhibition of non flux-controlling enzymes deters cancer glycolysis by accumulation of regulatory metabolites of controlling steps by Álvaro Marín-Hernández, José Salud Rodríguez-Zavala, Isis Del Mazo-Monsalvo, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez, Emma Saavedra

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Giardia duodenalis: Flavohemoglobin is involved in drug biotransformation and resistance to albendazole by Edar O. Pech-Santiago, Raúl Argüello-García, Citlali Vázquez, Emma Saavedra, Iliana González-Hernández, Helgi Jung-Cook, Steven P. Rafferty, M. Guadalupe Ortega-Pierres

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Giardia duodenalis: Flavohemoglobin is involved in drug biotransformation and resistance to albendazole. by Edar O Pech-Santiago, Raúl Argüello-García, Citlali Vázquez, Emma Saavedra, Iliana González-Hernández, Helgi Jung-Cook, Steven P Rafferty, M Guadalupe Ortega-Pierres

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Air-adapted Methanosarcina acetivorans shows high methane production and develops resistance against oxygen stress. by Ricardo Jasso-Chávez, M Geovanni Santiago-Martínez, Elizabeth Lira-Silva, Erika Pineda, Armando Zepeda-Rodríguez, Javier Belmont-Díaz, Rusely Encalada, Emma Saavedra, Rafael Moreno-Sánchez

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Physiological Role of Glutamate Dehydrogenase in Cancer Cells by Rafael Moreno-Sánchez, Álvaro Marín-Hernández, Juan C. Gallardo-Pérez, Silvia C. Pacheco-Velázquez, Diana X. Robledo-Cadena, Joaquín Alberto Padilla-Flores, Emma Saavedra, Sara Rodríguez-Enríquez

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Endoplasmic reticulum stress-sensing mechanism is activated in Entamoeba histolytica upon treatment with nitric oxide. by Julien Santi-Rocca, Sherri Smith, Christian Weber, Erika Pineda, Chung-Chau Hon, Emma Saavedra, Alfonso Olivos-García, Sandrine Rousseau, Marie-Agnès Dillies, Jean-Yves Coppée, Nancy Guillén

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Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs by Carlos Gaona-López, Lenci K. Vazquez-Jimenez, Alonzo Gonzalez-Gonzalez, Timoteo Delgado-Maldonado, Eyrá Ortiz-Pérez, Benjamín Nogueda-Torres, Adriana Moreno-Rodríguez, Karina Vázquez, Emma Saavedra, Gildardo Rivera

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New Amino Naphthoquinone Derivatives as Anti-<i>Trypanosoma cruzi</i> Agents Targeting Trypanothione Reductase by Christian Espinosa-Bustos, Mariana Ortiz Pérez, Alonzo Gonzalez-Gonzalez, Ana María Zarate, Gildardo Rivera, Javier A. Belmont-Díaz, Emma Saavedra, Mauricio A. Cuellar, Karina Vázquez, Cristian O. Salas

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Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling by Alfredo Juárez-Saldivar, Michael Schroeder, Sebastian Salentin, V. Joachim Haupt, Emma Saavedra, Citlali Vázquez, Francisco Reyes-Espinosa, Verónica Herrera-Mayorga, Juan Carlos Villalobos-Rocha, Carlos A. García-Pérez, Nuria E. Campillo, Gildardo Rivera

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Non-linearity of Metabolic Pathways Critically Influences the Choice of Machine Learning Model by Ophélie Lo-Thong-Viramoutou, Ophélie Lo-Thong-Viramoutou, Ophélie Lo-Thong-Viramoutou, Philippe Charton, Philippe Charton, Philippe Charton, Xavier F. Cadet, Brigitte Grondin-Perez, Emma Saavedra, Cédric Damour, Frédéric Cadet, Frédéric Cadet, Frédéric Cadet

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In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-<i>N</i>-oxide Derivatives against <i>Trypanosoma cruzi</i> as Trypanothione Reductase... by Alonzo González-González, Oscar Sánchez-Sánchez, R. Luise Krauth-Siegel, Maria Laura Bolognesi, Rogelio Gớmez-Escobedo, Benjamín Nogueda-Torres, Lenci K. Vázquez-Jiménez, Emma Saavedra, Rusely Encalada, José Carlos Espinoza-Hicks, Alma D. Paz-González, Gildardo Rivera

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Transcriptional Regulation of Energy Metabolism in Cancer Cells by Sara Rodríguez-Enríquez, Álvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Diana Xochiquetzal Robledo-Cadena, Jorge Luis Vargas-Navarro, Norma Angélica Corona de la Peña, Emma Saavedra, Rafael Moreno-Sánchez

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Cultivation of gastrointestinal microbiota in a new growth system revealed dysbiosis and metabolic disruptions in carcinoma-bearing rats by Betsy Anaid Peña-Ocaña, Yuki Hoshiko, Mayel Silva-Flores, Toshinari Maeda, Israel Pérez-Torres, Rodolfo García-Contreras, Wilbert Gutiérrez-Sarmiento, Luz Hernández-Esquivel, Álvaro Marín-Hernández, Rosina Sánchez-Thomas, Emma Saavedra, José Salud Rodríguez-Zavala, Ricardo Jasso-Chávez

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Acetate Promotes a Differential Energy Metabolic Response in Human HCT 116 and COLO 205 Colon Cancer Cells Impacting Cancer Cell Growth and Invasiveness by Sara Rodríguez-Enríquez, Diana Xochiquetzal Robledo-Cadena, Juan Carlos Gallardo-Pérez, Silvia Cecilia Pacheco-Velázquez, Citlali Vázquez, Emma Saavedra, Jorge Luis Vargas-Navarro, Betsy Alejandra Blanco-Carpintero, Álvaro Marín-Hernández, Ricardo Jasso-Chávez, Rusely Encalada, Luz Ruiz-Godoy, José Luis Aguilar-Ponce, Rafael Moreno-Sánchez

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