Quantitative approaches to drug safety: The 2022 PSP special issue ‌ Eric A. Sobie

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Regression analysis for constraining free parameters in electrophysiological models of cardiac cells. ‌ Amrita X Sarkar, Eric A Sobie

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In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte” ‌ Rafael Dariolli, Chiara Campana, Amy Gutierrez, Eric A. Sobie

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Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models. ‌ Chiara Campana, Eugenio Ricci, Chiara Bartolucci, Stefano Severi, Eric A Sobie

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Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence. ‌ Megan A Cummins, Pavan J Dalal, Marco Bugana, Stefano Severi, Eric A Sobie

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Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments. ‌ Janice Yang, Neil J Daily, Taylor K Pullinger, Tetsuro Wakatsuki, Eric A Sobie

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Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations ‌ Maria T. Mora, Jose M. Ferrero, Juan F. Gomez, Eric A. Sobie, Beatriz Trenor

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Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development ‌ Chiara Campana, Rafael Dariolli, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir, Eric A. Sobie

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Investigational Treatments for COVID‐19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions ‌ Meera Varshneya, Itziar Irurzun-Arana, Chiara Campana, Rafael Dariolli, Amy Gutierrez, Taylor K. Pullinger, Eric A. Sobie

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The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation. ‌ Young-Seon Lee, Minki Hwang, Jun-Seop Song, Changyong Li, Boyoung Joung, Eric A Sobie, Hui-Nam Pak

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Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics ‌ Jaehee V. Shim, Bryan Chun, Johan G. C. van Hasselt, Marc R. Birtwistle, Jeffrey J. Saucerman, Eric A. Sobie

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Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors ‌ Jaehee V. Shim, Jaehee V. Shim, Yuguang Xiong, Yuguang Xiong, Priyanka Dhanan, Rafael Dariolli, Rafael Dariolli, Evren U. Azeloglu, Evren U. Azeloglu, Bin Hu, Bin Hu, Gomathi Jayaraman, Gomathi Jayaraman, Christoph Schaniel, Marc R. Birtwistle, Ravi Iyengar, Ravi Iyengar, Nicole C. Dubois, Eric A. Sobie, Eric A. Sobie

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Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes ‌ Rebecca Josowitz, Sonia Mulero-Navarro, Nelson A. Rodriguez, Christine Falce, Ninette Cohen, Erik M. Ullian, Lauren A. Weiss, Katherine A. Rauen, Eric A. Sobie, Bruce D. Gelb

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Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression. ‌ Rebecca Josowitz, Jia Lu, Christine Falce, Sunita L D'Souza, Meng Wu, Ninette Cohen, Nicole C Dubois, Yong Zhao, Eric A Sobie, Glenn I Fishman, Bruce D Gelb

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Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity ‌ Yuguang Xiong, Tong Liu, Tong Chen, Jens Hansen, Bin Hu, Yibang Chen, Gomathi Jayaraman, Stephan Schürer, Dusica Vidovic, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Ravi Iyengar, Hong Li, Evren U. Azeloglu

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Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation ‌ Juan J. A. M. Muñoz, Rafael Dariolli, Caio Mateus da Silva, Elida A. Neri, Iuri C. Valadão, Lauro Thiago Turaça, Vanessa M. Lima, Mariana Lombardi Peres de Carvalho, Mariliza R. Velho, Eric A. Sobie, Jose E. Krieger

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Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity ‌ J. G. Coen van Hasselt, Rayees Rahman, Jens Hansen, Alan Stern, Jaehee V. Shim, Yuguang Xiong, Amanda Pickard, Gomathi Jayaraman, Bin Hu, Milind Mahajan, James M. Gallo, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Avner Schlessinger, Evren U. Azeloglu, Ravi Iyengar

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Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion ‌ Chrystian Junqueira Alves, Rafael Dariolli, Jonathan Haydak, Sangjo Kang, Theodore Hannah, Robert J. Wiener, Stefanie DeFronzo, Rut Tejero, Gabriele L. Gusella, Aarthi Ramakrishnan, Rodrigo Alves Dias, Alexandre Wojcinski, Santosh Kesari, Li Shen, Eric A. Sobie, José Paulo Rodrigues Furtado de Mendonça, Evren U. Azeloglu, Hongyan Zou, Roland H. Friedel

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Multiscale mapping of transcriptomic signatures for cardiotoxic drugs ‌ Jens Hansen, Yuguang Xiong, Mustafa M. Siddiq, Priyanka Dhanan, Bin Hu, Bhavana Shewale, Arjun S. Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Pedro Martinez, Kristin G. Beaumont, Robert Sebra, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth I. Berger, Angel Chan, Christoph Schaniel, Nicole C. Dubois, Ravi Iyengar

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