X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. by Jennifer K Colucci, Eric A Ortlund

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Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. by William H Hudson, Christine Youn, Eric A Ortlund

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Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. by Jamie T Bridgham, June Keay, Eric A Ortlund, Joseph W Thornton

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Evolution of minimal specificity and promiscuity in steroid hormone receptors. by Geeta N Eick, Jennifer K Colucci, Michael J Harms, Eric A Ortlund, Joseph W Thornton

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Identification of a lipid scrambling domain in ANO6/TMEM16F by Kuai Yu, Jarred M Whitlock, Kyleen Lee, Eric A Ortlund, Yuan Yuan Cui, H Criss Hartzell

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Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist by Suzanne G. Mays, Józef Stec, Xu Liu, Emma H. D’Agostino, Richard J. Whitby, Eric A. Ortlund

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Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity. by Melissa M Heintz, Jazmine A Eccles, Emily M Olack, Kristal M Maner-Smith, Eric A Ortlund, William S Baldwin

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Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity by Melissa M. Heintz, Jazmine A. Eccles, Emily M. Olack, Kristal M. Maner-Smith, Eric A. Ortlund, William S. Baldwin

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The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells by Jasmine C. Moody, Hiroshi Qadota, April R. Reedy, C. Denise Okafor, Niveda Shanmugan, Yohei Matsunaga, Courtney J. Christian, Eric A. Ortlund, Guy M. Benian

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Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. by Jamie T Bridgham, Geeta N Eick, Claire Larroux, Kirti Deshpande, Michael J Harms, Marie E A Gauthier, Eric A Ortlund, Bernard M Degnan, Joseph W Thornton

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FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells. by Alejandro Soto-Avellaneda, Alexandra E Oxford, Fabio Halla, Peyton Vasquez, Emily Oe, Anton D Pugel, Alyssa M Schoenfeld, Matthew C Tillman, André Cuevas, Eric A Ortlund, Brad E Morrison

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Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements by William H. Hudson, Ian Mitchelle S. de Vera, Jerome C. Nwachukwu, Emily R. Weikum, Austin G. Herbst, Qin Yang, David L. Bain, Kendall W. Nettles, Douglas J. Kojetin, Eric A. Ortlund

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High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease by Christopher S. Krumm, Renée S. Landzberg, Lavoisier Ramos-Espiritu, Carolina Adura, Xu Liu, Mariana Acuna, Yang Xie, Xu Xu, Matthew C. Tillman, Yingxia Li, J. Fraser Glickman, Eric A. Ortlund, John D. Ginn, David E. Cohen

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Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice by Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen

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Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced ApoptosisSummary by Alexandra A. Wolfarth, Xu Liu, Trevor M. Darby, Darra J. Boyer, Jocelyn B. Spizman, Joshua A. Owens, Bindu Chandrasekharan, Crystal R. Naudin, Krisztina Z. Hanley, Brian S. Robinson, Eric A. Ortlund, Rheinallt M. Jones, Andrew S. Neish

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Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease by Helaina E. Huneault, Chih-Yu Chen, Catherine C. Cohen, Xueyun Liu, Zachery R. Jarrell, Zhulin He, Karla E. DeSantos, Jean A. Welsh, Kristal M. Maner-Smith, Eric A. Ortlund, Jeffrey B. Schwimmer, Miriam B. Vos

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The Design and Immunogenicity of an HIV-1 Clade C Pediatric Envelope Glycoprotein Stabilized by Multiple Platforms by Sanjeev Kumar, Iván del Moral-Sánchez, Swarandeep Singh, Maddy L. Newby, Joel D. Allen, Tom P. L. Bijl, Yog Vaghani, Liang Jing, Rakesh Lodha, Eric A. Ortlund, Max Crispin, Anamika Patel, Rogier W. Sanders, Kalpana Luthra

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Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice by Samuel A. Druzak, Matteo Tardelli, Suzanne G. Mays, Mireille El Bejjani, Xulie Mo, Kristal M. Maner-Smith, Thomas Bowen, Michael L. Cato, Matthew C. Tillman, Akiko Sugiyama, Yang Xie, Haian Fu, David E. Cohen, Eric A. Ortlund

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The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry by Manoj Khadka, Andrei Todor, Kristal M. Maner-Smith, Jennifer K. Colucci, ViLinh Tran, David A. Gaul, Evan J. Anderson, Muktha S. Natrajan, Nadine Rouphael, Mark J. Mulligan, Circe E. McDonald, Mehul Suthar, Shuzhao Li, Eric A. Ortlund

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High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans. by Jeffrey M Collins, Douglas I Walker, Dean P Jones, Nestani Tukvadze, Ken H Liu, ViLinh T Tran, Karan Uppal, Jennifer K Frediani, Kirk A Easley, Neeta Shenvi, Manoj Khadka, Eric A Ortlund, Russell R Kempker, Henry M Blumberg, Thomas R Ziegler

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