Host-Pathogen Interactions after Lung Transplant: Are Cystic Fibrosis Patients Unique? per Eric D. Morrell, Erika D. Lease

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TLRs in COVID-19: How they drive immunopathology and the rationale for modulation per F. Linzee Mabrey, Eric D Morrell, Mark M Wurfel

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Endotracheal aspirates contain a limited number of lower respiratory tract immune cells per Marika Orlov, Eric D. Morrell, Victoria Dmyterko, Jessica A. Hamerman, Mark M. Wurfel, Carmen Mikacenic

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Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19. per Sarah E Holton, Mallorie Mitchem, Hamid Chalian, Sudhakar Pipavath, Eric D Morrell, Pavan K Bhatraju, Jessica A Hamerman, Cate Speake, Uma Malhotra, Mark M Wurfel, Steven E Ziegler, Carmen Mikacenic

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Evaluating construct validity of computable acute respiratory distress syndrome definitions in adults hospitalized with COVID-19: an electronic health records based approach per Neha A. Sathe, Su Xian, F. Linzee Mabrey, David R. Crosslin, Sean D. Mooney, Eric D. Morrell, Kevin Lybarger, Meliha Yetisgen, Gail P. Jarvik, Pavan K. Bhatraju, Mark M. Wurfel

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Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19 per Runa Kuley, Bhargavi Duvvuri, Jeffrey J. Wallin, Nam Bui, Mary Vic Adona, Nicholas G. O’Connor, Sharon K. Sahi, Ian B. Stanaway, Mark M. Wurfel, Eric D. Morrell, W. Conrad Liles, Pavan K. Bhatraju, Christian Lood

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Presence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus-2 on Admission Is Associated With Decreased Mortality in COVID-19 Critical Illness per F. Linzee Mabrey, MD, Leila R. Zelnick, PhD, Eric D. Morrell, MD, Nicholas G. O’Connor, BS, Andrew Hart, BA, Mark M. Wurfel, MD, PhD, W. Conrad Liles, MD, PhD, Pavan K. Bhatraju, MD, MSc

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The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure per Eric D. Morrell, Sarah E. Holton, Matthew Lawrance, Marika Orlov, Zoie Franklin, Mallorie A. Mitchem, Hannah DeBerg, Vivian H. Gersuk, Ashley Garay, Elizabeth Barnes, Ted Liu, Ithan D. Peltan, Angela Rogers, Steven Ziegler, Mark M. Wurfel, Carmen Mikacenic

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25-Hydroxycholesterol exacerbates vascular leak during acute lung injury per Jennifer H. Madenspacher, Eric D. Morrell, Jeffrey G. McDonald, Bonne M. Thompson, Yue Li, Konstantin G. Birukov, Anna A. Birukova, Renee D. Stapleton, Aidin Alejo, Peer W. Karmaus, Julie M. Meacham, Prashant Rai, Carmen Mikacenic, Mark M. Wurfel, Michael B. Fessler

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Phase 2, randomized, double-blind, placebo-controlled multi-center trial of the clinical and biological effects of anti-CD14 treatment in hospitalized patients with COVID-19 pneumo... per F. Linzee Mabrey, Hui Nian, Chang Yu, Elizabeth M. Barnes, Uma Malhotra, Carmen Mikacenic, Julia Goldstein, D. Shane O'Mahony, Julia Garcia-Diaz, Patricia Finn, Kirk Voelker, Eric D. Morrell, Wesley H. Self, Patrice M. Becker, Thomas R. Martin, Mark M. Wurfel

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Plasma Interleukin-6 Predicts Clinical Decline After Completion of Dexamethasone Therapy in Severe COVID-19 per F. Linzee Mabrey, MD, Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Leila R. Zelnick, PhD, Neha A. Sathe, MD, Nicholas G. O’Connor, BS, Carmen Mikacenic, MD, Thomas R. Martin, MD, W. Conrad Liles, MD, PhD, Mark M. Wurfel, MD, PhD

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Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes per Pavan K. Bhatraju, Max Cohen, Ryan J. Nagao, Eric D. Morrell, Susanna Kosamo, Xin-Ya Chai, Robin Nance, Victoria Dmyterko, Joseph Delaney, Jason D. Christie, Kathleen D. Liu, Carmen Mikacenic, Sina A. Gharib, W. Conrad Liles, Ying Zheng, David C. Christiani, Jonathan Himmelfarb, Mark M. Wurfel

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Biomarker Signatures of Severe Acute Kidney Injury in a Critically Ill Cohort of COVID-19 and Non-COVID-19 Acute Respiratory Illness per Neha A. Sathe, MD, MSc, Ana Mostaghim, MD, Elizabeth Barnes, BS, Nicholas G. O’Connor, BS, Sharon K. Sahi, MS, Sana S. Sakr, PhD, Jana M. Zahlan, BS, Craig H. Smith, MD, Michael Fitzpatrick, BS, Eric D. Morrell, MD, W. Conrad Liles, MD, PhD, Pavan K. Bhatraju, MD, MSc

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Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations per Louisa Helms, Silvia Marchiano, Ian B. Stanaway, Tien-Ying Hsiang, Benjamin A. Juliar, Shally Saini, Yan Ting Zhao, Akshita Khanna, Rajasree Menon, Fadhl Alakwaa, Carmen Mikacenic, Eric D. Morrell, Mark M. Wurfel, Matthias Kretzler, Jennifer L. Harder, Charles E. Murry, Jonathan Himmelfarb, Hannele Ruohola-Baker, Pavan K. Bhatraju, Michael Gale Jr., Benjamin S. Freedman

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Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study per Pavan K. Bhatraju, Eric D. Morrell, Leila Zelnick, Neha A. Sathe, Xin-Ya Chai, Sana S. Sakr, Sharon K. Sahi, Anthony Sader, Dawn M. Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K. Bray, Sudhakar Pipavath, Bryan R. Kestenbaum, W. Conrad Liles, Susan L. Fink, T. Eoin West, Laura Evans, Carmen Mikacenic, Mark M. Wurfel

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Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis per Susan P. Canny, MD, PhD, Ian B. Stanaway, PhD, Sarah E. Holton, MD, PhD, Mallorie Mitchem, BA, Allison R. O’Rourke, PhD, Stephan Pribitzer, PhD, Sarah K. Baxter, MD, PhD, Mark M. Wurfel, MD, PhD, Uma Malhotra, MD, Jane H. Buckner, MD, Pavan K. Bhatraju, MD, Eric D. Morrell, MD, Cate Speake, PhD, Carmen Mikacenic, MD, Jessica A. Hamerman, PhD

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COVID-19 Across Pandemic Variant Periods: The Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study per Vikramjit Mukherjee, MD, FRCP, Radu Postelnicu, MD, Chelsie Parker, MS, Patrick S. Rivers, PhD, George L. Anesi, MD, MSCE, MBE, Adair Andrews, RN, MATD, Erin Ables, MA, Eric D. Morrell, MD, MA, David M. Brett-Major, MD, MPH, M. Jana Broadhurst, MD, PhD, J. Perren Cobb, MD, Amy Irwin, DNP, RN, Christopher J. Kratochvil, MD, Kelsey Krolikowski, BA, Vishakha K. Kumar, MD, MBA, Douglas P. Landsittel, PhD, Richard A. Lee, MD, Janice M. Liebler, MD, Leopoldo N. Segal, MD, Jonathan E. Sevransky, MD, MHS, Avantika Srivastava, MS, Timothy M. Uyeki, MD, MPH, Mark M. Wurfel, MD, PhD, David Wyles, MD, Laura E. Evans, MD, MSc, Karen Lutrick, PhD, Pavan K. Bhatraju, MD, MSc, on behalf of the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group

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Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity per Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Ian B. Stanaway, PhD, Neha A. Sathe, MD, MSc, Avantika Srivastava, MS, Radu Postelnicu, MD, Richard Green, BS, Adair Andrews, BSN, Martin Gonzalez, BS, Christopher J. Kratochvil, MD, Vishakha K. Kumar, BS, Tien-Ying Hsiang, PhD, Michael Gale, Jr, PhD, George L. Anesi, MD, David Wyles, MD, M. Jana Broadhurst, MD, PhD, David Brett-Major, MD, MPH, Vikramjit Mukherjee, MD, Jonathan E. Sevransky, MD, Douglas Landsittel, PhD, Chi Hung, MD, William A. Altemeier, MD, Sina A. Gharib, MD, Timothy M. Uyeki, MD, MPH, J. Perren Cobb, MD, Janice M. Liebler, MD, David R. Crosslin, PhD, Gail P. Jarvik, MD, Leopoldo N. Segal, MD, Laura Evans, MD, Carmen Mikacenic, MD, Mark M. Wurfel, MD, PhD

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