Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain by Hunter B. Dean, Hunter B. Dean, Hunter B. Dean, Hunter B. Dean, Hunter B. Dean, Erik D. Roberson, Erik D. Roberson, Erik D. Roberson, Yuhua Song

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A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity by Travis Rush, Jonathan R. Roth, Samantha J. Thompson, Adam R. Aldaher, J. Nicholas Cochran, Erik D. Roberson

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Noradrenergic dysfunction in Alzheimer’s disease by Mary eGannon, Pulin eChe, Yunjia eChen, Kai eJiao, Erik D Roberson, Qin eWang

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Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia by Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal

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Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice by Andrew E. Arrant, Anthony J. Filiano, Aashka R. Patel, Madelyn Q. Hoffmann, Nicholas R. Boyle, Shreya N. Kashyap, Vincent C. Onyilo, Allen H. Young, Erik D. Roberson

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Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy. by Yuliya Voskobiynyk, Gopal Battu, Stephanie A Felker, J Nicholas Cochran, Megan P Newton, Laura J Lambert, Robert A Kesterson, Richard M Myers, Gregory M Cooper, Erik D Roberson, Gregory S Barsh

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Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability by Yuliya Voskobiynyk, Jonathan R Roth, J Nicholas Cochran, Travis Rush, Nancy VN Carullo, Jacob S Mesina, Mohammad Waqas, Rachael M Vollmer, Jeremy J Day, Lori L McMahon, Erik D Roberson

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Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice by Xiaoxiao Hao, Zhaofei Li, Wei Li, Jannet Katz, Suzanne M. Michalek, Scott R. Barnum, Lucas Pozzo-Miller, Takashi Saito, Takashi Saito, Takaomi C. Saido, Qin Wang, Erik D. Roberson, Ping Zhang

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Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits. by Youngnam N Jin, Ping-Chung Chen, Jennifer A Watson, Brandon J Walters, Scott E Phillips, Karen Green, Robert Schmidt, Julie A Wilson, Gail V Johnson, Erik D Roberson, Lynn E Dobrunz, Scott M Wilson

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Challenges and Opportunities for Characterizing Cognitive Aging across Species by Erik D Roberson, R. Anthony DeFazio, Carol A. Barnes, Gene E. Alexander, Jennifer L. Bizon, Dawn eBowers, Thomas C Foster, Elizabeth L. Glisky, Bonnie E. Levin, Lee eRyan, Clinton B. Wright, David S. Geldmacher

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Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations by Andrew E. Arrant, Jonathan R. Roth, Nicholas R. Boyle, Shreya N. Kashyap, Madelyn Q. Hoffmann, Charles F. Murchison, Eliana Marisa Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Erik D. Roberson

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A REDCap-based model for electronic consent (eConsent): Moving toward a more personalized consent by Colleen E. Lawrence, Leah Dunkel, Mark McEver, Tiffany Israel, Robert Taylor, Germán Chiriboga, Karin Valentine Goins, Elizabeth J. Rahn, Amy S. Mudano, Erik D. Roberson, Carol Chambless, Virginia G. Wadley, Maria I. Danila, Melissa A. Fischer, Yvonne Joosten, Kenneth G. Saag, Jeroan J. Allison, Stephenie C. Lemon, Paul A. Harris

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Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals by Chengjie Xiong, Jingqin Luo, David A. Wolk, Leslie M. Shaw, Erik D. Roberson, Charles F. Murchison, Rachel L. Henson, Tammie L. S. Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N. Gremminger, Krista L. Moulder, David S. Geldmacher, Olivio J. Clay, Ganesh Babulal, Carlos Cruchaga, David M. Holtzman, Randall J. Bateman, John C. Morris, Suzanne E. Schindler

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Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models by Stephanie R. Miller, Kevin Luxem, Kelli Lauderdale, Pranav Nambiar, Patrick S. Honma, Katie K. Ly, Shreya Bangera, Mary Bullock, Jia Shin, Nick Kaliss, Yuechen Qiu, Catherine Cai, Kevin Shen, K. Dakota Mallen, Zhaoqi Yan, Andrew S. Mendiola, Takashi Saito, Takaomi C. Saido, Alexander R. Pico, Reuben Thomas, Erik D. Roberson, Katerina Akassoglou, Pavol Bauer, Stefan Remy, Jorge J. Palop

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Development of a multi-component intervention to promote participation of Black and Latinx individuals in biomedical research by Maria I. Danila, Jeroan J. Allison, Karin Valentine Goins, Germán Chiriboga, Melissa Fischer, Melissa Puliafico, Amy S. Mudano, Elizabeth J. Rahn, Jeanne Merchant, Colleen E. Lawrence, Leah Dunkel, Tiffany Israel, Bruce Barton, Fred Jenoure, Tiffany Alexander, Danny Cruz, Marva Douglas, Jacqueline Sims, Al Richmond, Erik D. Roberson, Carol Chambless, Paul A. Harris, Kenneth G. Saag, Stephenie C. Lemon

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Comparison of Pittsburgh compound B and florbetapir in cross‐sectional and longitudinal studies by Yi Su, Shaney Flores, Guoqiao Wang, Russ C. Hornbeck, Benjamin Speidel, Nelly Joseph‐Mathurin, Andrei G. Vlassenko, Brian A. Gordon, Robert A. Koeppe, William E. Klunk, Clifford R. Jack Jr., Martin R. Farlow, Stephen Salloway, Barbara J. Snider, Sarah B. Berman, Erik D. Roberson, Jared Brosch, Ivonne Jimenez‐Velazques, Christopher H. vanDyck, Douglas Galasko, Shauna H. Yuan, Suman Jayadev, Lawrence S. Honig, Serge Gauthier, Ging‐Yuek R. Hsiung, Mario Masellis, William S. Brooks, Michael Fulham, Roger Clarnette, Colin L. Masters, David Wallon, Didier Hannequin, Bruno Dubois, Jeremie Pariente, Raquel Sanchez‐Valle, Catherine Mummery, John M. Ringman, Michel Bottlaender, Gregory Klein, Smiljana Milosavljevic‐Ristic, Eric McDade, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger

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Nonlinear Z‐score modeling for improved detection of cognitive abnormality by John Kornak, Julie Fields, Walter Kremers, Sara Farmer, Hilary W. Heuer, Leah Forsberg, Danielle Brushaber, Amy Rindels, Hiroko Dodge, Sandra Weintraub, Lilah Besser, Brian Appleby, Yvette Bordelon, Jessica Bove, Patrick Brannelly, Christina Caso, Giovanni Coppola, Reilly Dever, Christina Dheel, Bradford Dickerson, Susan Dickinson, Sophia Dominguez, Kimiko Domoto‐Reilly, Kelley Faber, Jessica Ferrall, Ann Fishman, Jamie Fong, Tatiana Foroud, Ralitza Gavrilova, Deb Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff‐Radford, Neill Graff‐Radford, Ian M. Grant, Murray Grossman, Dana Haley, John Hsiao, Robin Hsiung, Edward D. Huey, David Irwin, David Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, Daniel Kaufer, Diana Kerwin, David Knopman, Ruth Kraft, Joel Kramer, Walter Kukull, Maria Lapid, Irene Litvan, Peter Ljubenkov, Diane Lucente, Codrin Lungu, Ian Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott McGinnis, Emily McKinley, Mario Mendez, Bruce Miller, Namita Multani, Chiadi Onyike, Jaya Padmanabhan, Alexander Pantelyat, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Erik D. Roberson, Emily Rogalski‐Miller, Pheth Sengdy, Les Shaw, Adam M. Staffaroni, Margaret Sutherland, Jeremy Syrjanen, Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, John Trojanowski, Ping Wang, Bonnie Wong, Zbigniew Wszolek, Brad Boeve, Adam Boxer, Howard Rosen, ARTFL/LEFFTDS Consortium

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