Erik De Clercq
Erik De Clercq M.D. Ph.D., (1941) is a Belgian physician and biologist. He studied medicine at the Catholic University of Leuven (Leuven, Belgium). He did research and later became a professor at the Department of Medicine, where he specialised in microbiology and immunology. He worked at the Rega Institute for Medical Research. He is one of the founders and the second president of the International Society for Antiviral Research.Since 1976 Erik De Clercq has collaborated on the development of new antiretroviral drugs with Antonín Holý, of the Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czechoslovak Academy of Sciences in Prague, Czech Republic. Together they discovered amongst others Tenofovir.
In 2008 he received the European Inventor Award Lifetime Achievement for landmark contributions to antiviral treatment, including the development of the drug cocktail for AIDS.
In 2010 De Clercq was awarded the 2010 Dr. Paul Janssen Award for Biomedical Research. He was recognized for his landmark discoveries in anti-HIV medications, including nucleotide analogues, and inventions or co-inventions of several approved drugs for anti-viral therapy. Provided by Wikipedia
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Hydrogen Bonding (Base Pairing) in Antiviral Activity by Erik De Clercq
Published 2023-05-01
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Selected Milestones in Antiviral Drug Development by Erik De Clercq
Published 2024-01-01
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1984—Discovery of the First Anti-HIV Drug, Suramin by Erik De Clercq
Published 2021-08-01
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Cidofovir for the Treatment of Molluscum Contagiosum Virus by Erik De Clercq
Published 2022-11-01
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FV-100 for the Treatment of Varicella-Virus (VZV) Infections: Quo Vadis? by Erik De Clercq
Published 2022-04-01
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Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective by Miao Miao, Erik De Clercq, Guangdi Li
Published 2021-04-01
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Towards Efficient and Accurate SARS-CoV-2 Genome Sequence Typing Based on Supervised Learning Approaches by Miao Miao, Erik De Clercq, Guangdi Li
Published 2022-09-01
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Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variant... by Zhao Wang, Heng Zhang, Zhen Gao, Zihao Sang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Published 2024-03-01
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Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region by Tao Zhang, Zhongxia Zhou, Fabao Zhao, Zihao Sang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Published 2022-11-01
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Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Da Feng, Hao Lin, Liyang Jiang, Zhao Wang, Yanying Sun, Zhongxia Zhou, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Published 2022-11-01
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An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus in Mice by Jan Haviernik, Ludek Eyer, Antoine Nougairède, Marie Uhlířová, Jean-Sélim Driouich, Darina Zouharová, James Jason Valdés, Ernest Gould, Erik De Clercq, Xavier de Lamballerie, Daniel Ruzek
Published 2020-06-01
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Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators by Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Published 2022-11-01
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Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles by Shenghua Gao, Letian Song, Yusen Cheng, Fabao Zhao, Dongwei Kang, Shu Song, Mianling Yang, Bing Ye, Wei Zhao, Yajie Tang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Published 2023-06-01
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Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study by Zhenzhen Zhou, Bairu Meng, Jiaqi An, Fabao Zhao, Yanying Sun, Dan Zeng, Wenna Wang, Shenghua Gao, Yu Xia, Caiyun Dun, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Published 2023-01-01
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