Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay by Morissette, P, Polak, S, Chain, A, Zhai, J, Imredy, JP, Wildey, MJ, Travis, J, Fitzgerald, K, Fanelli, P, Passini, E, Rodriguez, B, Sannajust, F, Regan, C