Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. by Zhou, L, Opalinska, J, Sohal, D, Yu, Y, Mo, Y, Bhagat, T, Abdel-Wahab, O, Fazzari, M, Figueroa, M, Alencar, C, Zhang, J, Kambhampati, S, Parmar, S, Nischal, S, Hueck, C, Suzuki, M, Freidman, E, Pellagatti, A, Boultwood, J, Steidl, U, Sauthararajah, Y, Yajnik, V, McMahon, C, Gore, S, Platanias, L

Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. by Zhou, L, McMahon, C, Bhagat, T, Alencar, C, Yu, Y, Fazzari, M, Sohal, D, Heuck, C, Gundabolu, K, Ng, C, Mo, Y, Shen, W, Wickrema, A, Kong, G, Friedman, E, Sokol, L, Mantzaris, I, Mantzaris, G, Pellagatti, A, Boultwood, J, Platanias, L, Steidl, U, Yan, L, Yingling, J, Lahn, M