Editorial: Sepsis and COVID-19: Cross-Talk in Signaling Pathways and in Therapeutic Perspectives by Reinaldo Salomão, Fernando Queiróz Cunha, Felipe Dal-Pizzol

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Targeting PARP1 to Enhance Anticancer Checkpoint Immunotherapy Response: Rationale and Clinical Implications by Carlos Wagner S. Wanderley, Carlos Wagner S. Wanderley, Tatiana Strava Correa, Mariana Scaranti, Fernando Queiroz Cunha, Fernando Queiroz Cunha, Romualdo Barroso-Sousa

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Efeito do dinitrato de isossorbida sobre a hiperalgesia corneana induzida por lipopolissacarídeo by Jayter Silva Paula, Mariana Bellini Oliveira, Fernando Chahud, Carolina Maria Modulo, Eduardo Melani Rocha, Fernando Queiróz Cunha

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Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect by Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant’Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury, Gisele Picolo

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TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection. by Laís Amorim Sacramento, Luciana Benevides, Sandra Regina Maruyama, Lucas Tavares, Kiyoshi Ferreira Fukutani, Marcela Francozo, Tim Sparwasser, Fernando Queiroz Cunha, Roque Pacheco Almeida, João Santana da Silva, Vanessa Carregaro

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Increased blood neutrophil extracellular traps (NETs) associated with early life stress: translational findings in recent-onset schizophrenia and rodent model by Fabiana Corsi-Zuelli, Ayda Henriques Schneider, Thamyris Santos-Silva, Camila Marcelino Loureiro, Rosana Shuhama, Paulo Rossi Menezes, Francisco Silveira Guimarães, Felipe Villela Gomes, Fernando Queiroz Cunha, Paulo Louzada-Junior, Cristina Marta Del-Ben

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Neutrophil paralysis in Plasmodium vivax malaria. by Fabiana Maria de Souza Leoratti, Silvia Cellone Trevelin, Fernando Queiroz Cunha, Bruno Coelho Rocha, Pedro Augusto Carvalho Costa, Humberto Doriguêtto Gravina, Mauro Shugiro Tada, Dhelio Batista Pereira, Douglas Taylor Golenbock, Lis Ribeiro do Valle Antonelli, Ricardo T Gazzinelli

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Paradoxical roles of the neutrophil in sepsis: protective and deleterious by Fabiane eSônego, Fabiane eSônego, Fernanda Vargas e Silva Castanheira, Raphael Gomes Ferreira, Alexandre eKanashiro, Caio Abner Vitorino Golçalves Leite, Daniele Carvalho Nascimento, David Fernando Colón, Vanessa Fátima Borges, José C Alves-Filho, Fernando Queiróz Cunha

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NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection. by Helton C Santiago, Claudia Z Gonzalez Lombana, Juan P Macedo, Lara Utsch, Wagner L Tafuri, Maria José Campagnole-Santos, Rosana O Alves, José C F Alves-Filho, Alvaro J Romanha, Fernando Queiroz Cunha, Mauro M Teixeira, Rafael Radi, Leda Q Vieira

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Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome by Josiane Fernandes Silva, Vania C. Olivon, Fabiola Leslie A. C. Mestriner, Camila Ziliotto Zanotto, Raphael Gomes Ferreira, Nathanne Santos Ferreira, Carlos Alberto Aguiar Silva, João Paulo Mesquita Luiz, Juliano Vilela Alves, Rubens Fazan, Fernando Queiróz Cunha, Jose Carlos Alves-Filho, Rita C. Tostes

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Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways by Cintia Scucuglia Heluany, Paula Barbim Donate, Ayda Henriques Schneider, André Luis Fabris, Renan Augusto Gomes, Isadora Maria Villas-Boas, Denise Vilarinho Tambourgi, Tarcilia Aparecida da Silva, Gustavo Henrique Goulart Trossini, Giovanna Nalesso, Eduardo Lani Volpe Silveira, Fernando Queiroz Cunha, Sandra Helena Poliselli Farsky

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Methotrexate and Non-Surgical Periodontal Treatment Change the Oral–Gut Microbiota in Rheumatoid Arthritis: A Prospective Cohort Study by Sicília Rezende Oliveira, José Alcides Almeida de Arruda, Jôice Dias Corrêa, Valessa Florindo Carvalho, Julliane Dutra Medeiros, Ayda Henriques Schneider, Caio Cavalcante Machado, Letícia Fernanda Duffles, Gabriel da Rocha Fernandes, Débora Cerqueira Calderaro, Mario Taba Júnior, Lucas Guimarães Abreu, Sandra Yasuyo Fukada, Renê Donizeti Ribeiro Oliveira, Paulo Louzada-Júnior, Fernando Queiroz Cunha, Tarcília Aparecida Silva

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Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition by Juliana Y Sakita, Jefferson Elias-Oliveira, Daniela Carlos, Emerson de Souza Santos, Luciana Yamamoto Almeida, Tathiane M Malta, Mariângela O Brunaldi, Sergio Albuquerque, Cleide Lúcia Araújo Silva, Marcus V Andrade, Vania L D Bonato, Sergio Britto Garcia, Fernando Queiroz Cunha, Guilherme Cesar Martelossi Cebinelli, Ronaldo B Martins, Jason Matthews, Leandro Colli, Francis L Martin, Sergio A Uyemura, Vinicius Kannen

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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner by Tatiana Dandolini Saccon, Felippe Mousovich-Neto, Raissa Guimarães Ludwig, Victor Corasolla Carregari, Ana Beatriz dos Anjos Souza, Amanda Stephane Cruz dos Passos, Matheus Cavalheiro Martini, Priscilla Paschoal Barbosa, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Julia Forato, Mariene Ribeiro Amorim, Rafael Elias Marques, Flavio Protasio Veras, Ester Barreto, Tiago Tomazini Gonçalves, Isadora Marques Paiva, Narayana P. B. Fazolini, Carolina Mie Kawagosi Onodera, Ronaldo Bragança Martins Junior, Paulo Henrique Cavalcanti de Araújo, Sabrina Setembre Batah, Rosa Maria Mendes Viana, Danilo Machado de Melo, Alexandre Todorovic Fabro, Eurico Arruda, Fernando Queiroz Cunha, Thiago Mattar Cunha, Marco Antônio M. Pretti, Bradley Joseph Smith, Henrique Marques-Souza, Thiago L. Knittel, Gabriel Palermo Ruiz, Gerson S. Profeta, Tereza Cristina Minto Fontes-Cal, Mariana Boroni, Marco Aurélio Ramirez Vinolo, Alessandro S. Farias, Pedro Manoel M. Moraes-Vieira, Joyce Maria Annichino Bizzacchi, Tambet Teesalu, Felipe David Mendonça Chaim, Everton Cazzo, Elinton Adami Chaim, José Luiz Proença-Módena, Daniel Martins-de-Souza, Mariana Kiomy Osako, Luiz Osório Leiria, Marcelo A. Mori

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Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology by Camila Meirelles S. Silva, Carlos Wagner S. Wanderley, Flavio Protasio Veras, Augusto Velozo Gonçalves, Mikhael Haruo Fernandes Lima, Juliana Escher Toller-Kawahisa, Giovanni Freitas Gomes, Daniele Carvalho Nascimento, Valter V. Silva Monteiro, Isadora Marques Paiva, Cícero José Luíz Ramos Almeida, Diego Brito Caetité, Juliana Costa Silva, Maria Isabel Fernandes Lopes, Letícia Pastorelli Bonjorno, Marcela Cavichioli Giannini, Natalia Brasil Amaral, Maíra Nilson Benatti, Rodrigo Carvalho Santana, Luis Eduardo Alves Damasceno, Bruna Manuella Souza Silva, Ayda Henriques Schneider, Icaro Maia Santos Castro, Juan Carlo Santos Silva, Amanda Pereira Vasconcelos, Tiago Tomazini Gonçalves, Sabrina Setembre Batah, Tamara Silva Rodrigues, Victor Ferreira Costa, Marjorie Cornejo Pontelli, Ronaldo B. Martins, Timna Varela Martins, Danillo Lucas Alves Espósito, Guilherme Cesar Martelossi Cebinelli, Benedito Antônio Lopes da Fonseca, Luiz Osório Silveira Leiria, Larissa Dias Cunha, Eurico Arruda, Helder I. Nakaia, Alexandre Todorovic Fabro, Rene D. R. Oliveira, Dario S. Zamboni, Paulo Louzada-Junior, Thiago Mattar Cunha, José Carlos Farias Alves-Filho, Fernando Queiroz Cunha

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