Structural and mechanistic studies on PHD2 and the discovery of potential inhibitors by Figg, WD

Human prolyl hydroxylase domain 2 reacts with O 2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes by Fiorini, G, Marshall, SA, Figg, WD, Myers, WK, Brewitz, L, Schofield, CJ

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2 by Figg, WD, Fiorini, G, Chowdhury, R, Nakashima, Y, Tumber, A, McDonough, MA, Schofield, CJ

Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro by Elechalawar CK, Hossen MN, Shankarappa P, Peer CJ, Figg WD, Robertson JD, Bhattacharya R, Mukherjee P

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Structural basis of prolyl hydroxylase domain inhibition by Molidustat by Figg, WD, McDonough, MA, Chowdhury, R, Nakashima, Y, Zhang, Z, Holt-Martyn, JP, Krajnc, A, Schofield, CJ

Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α by Corner, TP, Teo, RZR, Wu, Y, Salah, E, Nakashima, Y, Fiorini, G, Tumber, A, Brasnett, A, Holt-Martyn, JP, Figg, WD, Zhang, X, Brewitz, L, Schofield, CJ