Review: Beyond KRAS: perspectives on new potential markers of intrinsic and acquired resistance to epidermal growth factor receptor inhibitors in metastatic colorectal cancer by Fotios Loupakis, Chiara Cremolini, Gabriella Fontanini, Irene Stasi, Lisa Salvatore, Alfredo Falcone

Get full text

Tumor mutation burden: from comprehensive mutational screening to the clinic by Francesca Galuppini, Carlo Alberto Dal Pozzo, Jutta Deckert, Fotios Loupakis, Matteo Fassan, Raffaele Baffa

Get full text

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target by Lisa Salvatore, Maria Alessandra Calegari, Fotios Loupakis, Matteo Fassan, Brunella Di Stefano, Maria Bensi, Emilio Bria, Giampaolo Tortora

Get full text

LONG-NONCODING RNAs in gastroesophageal cancers by Giuseppe Nicolò Fanelli, Pierluigi Gasparini, Irene Coati, Ri Cui, Hubert Pakula, Basudev Chowdhury, Nicola Valeri, Fotios Loupakis, Juozas Kupcinskas, Rocco Cappellesso, Matteo Fassan

Get full text

MicroRNAs as Predictive Biomarkers of Resistance to Targeted Therapies in Gastrointestinal Tumors by Valentina Angerilli, Francesca Galuppini, Gianluca Businello, Luca Dal Santo, Edoardo Savarino, Stefano Realdon, Vincenza Guzzardo, Lorenzo Nicolè, Vanni Lazzarin, Sara Lonardi, Fotios Loupakis, Matteo Fassan

Get full text

Treatment with checkpoint inhibitors in a metastatic colorectal cancer patient with molecular and immunohistochemical heterogeneity in MSI/dMMR status by Fotios Loupakis, Giulia Maddalena, Ilaria Depetris, Sabina Murgioni, Francesca Bergamo, Angelo Paolo Dei Tos, Massimo Rugge, Giada Munari, Andrew Nguyen, Christopher Szeto, Vittorina Zagonel, Sara Lonardi, Matteo Fassan

Get full text

Practical considerations in the use of regorafenib in metastatic colorectal cancer by Fotios Loupakis, Lorenzo Antonuzzo, Jean-Baptiste Bachet, Feng-Che Kuan, Teresa Macarulla, Filippo Pietrantonio, Rui-Hua Xu, Hiroya Taniguchi, Thomas Winder, Satoshi Yuki, Shan Zeng, Tanios Bekaii-Saab

Get full text

Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients by Nico B. Volz, Diana L. Hanna, Sebastian Stintzing, Wu Zhang, Dongyun Yang, Shu Cao, Yan Ning, Satoshi Matsusaka, Yu Sunakawa, Martin D. Berger, Chiara Cremolini, Fotios Loupakis, Alfredo Falcone, Heinz-Josef Lenz

Get full text

Single Nucleotide Polymorphisms in MiRNA Binding Sites of Nucleotide Excision Repair-Related Genes Predict Clinical Benefit of Oxaliplatin in FOLFOXIRI Plus Bevacizumab: Analysis o... by Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Wu Zhang, Dongyun Yang, Chiara Cremolini, Sabina Murgioni, Sara Lonardi, Yan Ning, Satoshi Okazaki, Martin D. Berger, Yuji Miyamoto, Afsaneh Barzi, Fotios Loupakis, Alfredo Falcone, Heinz-Josef Lenz

Get full text

A polymorphism in the cachexia-associated gene INHBA predicts efficacy of regorafenib in patients with refractory metastatic colorectal cancer. by Yuji Miyamoto, Marta Schirripa, Mitsukuni Suenaga, Shu Cao, Wu Zhang, Satoshi Okazaki, Martin D Berger, Satoshi Matsusaka, Dongyun Yang, Yan Ning, Hideo Baba, Fotios Loupakis, Sara Lonardi, Filippo Pietrantonio, Beatrice Borelli, Chiara Cremolini, Toshiharu Yamaguchi, Heinz-Josef Lenz

Get full text

Impact of Pre-Analytical Factors on MSI Test Accuracy in Mucinous Colorectal Adenocarcinoma: A Multi-Assay Concordance Study by Umberto Malapelle, Paola Parente, Francesco Pepe, Caterina De Luca, Pellegrino Cerino, Claudia Covelli, Mariangela Balestrieri, Gianluca Russo, Antonio Bonfitto, Pasquale Pisapia, Fabiola Fiordelisi, Maria D’Armiento, Dario Bruzzese, Fotios Loupakis, Filippo Pietrantonio, Maria Triassi, Matteo Fassan, Giancarlo Troncone, Paolo Graziano

Get full text

Comprehensive Genomic Profiling (CGP)-Informed Personalized Molecular Residual Disease (MRD) Detection: An Exploratory Analysis from the PREDATOR Study of Metastatic Colorectal Can... by Sara Lonardi, Halla Nimeiri, Chang Xu, Daniel R. Zollinger, Russell W. Madison, Alexander D. Fine, Ole Gjoerup, Cosimo Rasola, Valentina Angerilli, Shruti Sharma, Hsin-Ta Wu, Charuta C. Palsuledesai, Meenakshi Malhotra, Alexey Aleshin, Fotios Loupakis, Elise Renkonen, Priti Hegde, Matteo Fassan

Get full text

Correction to: Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases by Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli, Nicola Veronese, Claudio Luchini, Massimo Rugge

Get full text

Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases by Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli, Nicola Veronese, Claudio Luchini, Massimo Rugge

Get full text

A Real-World Application of Liquid Biopsy in Metastatic Colorectal Cancer: The Poseidon Study by Letizia Procaccio, Francesca Bergamo, Francesca Daniel, Cosimo Rasola, Giada Munari, Paola Biason, Stefania Crucitta, Giulia Barsotti, Giulia Zanella, Valentina Angerilli, Cristina Magro, Silvia Paccagnella, Veronica Di Antonio, Fotios Loupakis, Romano Danesi, Vittorina Zagonel, Marzia Del Re, Sara Lonardi, Matteo Fassan

Get full text

Correction: Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case by Matteo Fassan, Chiara Cremolini, Matteo Benelli, Elisa Fontana, Filippo Pagani, Daniele Rossini, Giovanni Fucà, Adele Busico, Elena Conca, Samantha Di Donato, Fotios Loupakis, Marta Schirripa, Sara Lonardi, Beatrice Borelli, Elena Ongaro, Katherine Eason, Mariaelena Casagrande, Anguraj Sadanandam, Filippo de Braud, Alfredo Falcone

Get full text

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth facto... by Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert

Get full text

Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab. by Fotios Loupakis, Chiara Cremolini, Dongyun Yang, Lisa Salvatore, Wu Zhang, Takeru Wakatsuki, Pierre Bohanes, Marta Schirripa, Leonor Benhaim, Sara Lonardi, Carlotta Antoniotti, Giuseppe Aprile, Francesco Graziano, Annamaria Ruzzo, Sara Lucchesi, Monica Ronzoni, Ferdinando De Vita, Giuseppe Tonini, Alfredo Falcone, Heinz-Josef Lenz

Get full text

NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients. by Marta Schirripa, Wu Zhang, Dongyun Yang, Shu Cao, Satoshi Okazaki, Fotios Loupakis, Martin D Berger, Yan Ning, Yuji Miyamoto, Mitsukuni Suenaga, Giulia Alberti, Jordan D West, Sara Lonardi, Taline Khoukaz, Francesca Bergamo, Francesca Battaglin, Carlotta Antoniotti, Alfredo Falcone, Sebastian Stintzing, Volker Heinemann, Heinz-Josef Lenz

Get full text

Final results of DESTINY-CRC01 investigating trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer by Takayuki Yoshino, Maria Di Bartolomeo, Kanwal Raghav, Toshiki Masuishi, Fotios Loupakis, Hisato Kawakami, Kensei Yamaguchi, Tomohiro Nishina, Zev Wainberg, Elena Elez, Javier Rodriguez, Marwan Fakih, Fortunato Ciardiello, Kapil Saxena, Kojiro Kobayashi, Emarjola Bako, Yasuyuki Okuda, Gerold Meinhardt, Axel Grothey, Salvatore Siena, DESTINY-CRC01 investigators

Get full text