Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse. by Patrick Pla, Sophie Orvoen, Caroline Benstaali, Sophie Dodier, Alain M Gardier, Denis J David, Sandrine Humbert, Frédéric Saudou

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Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease by Amandine Virlogeux, Eve Moutaux, Wilhelm Christaller, Aurélie Genoux, Julie Bruyère, Elodie Fino, Benoit Charlot, Maxime Cazorla, Frédéric Saudou

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Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning by Hélène Vitet, Julie Bruyère, Hao Xu, Claire Séris, Jacques Brocard, Yah-Sé Abada, Benoît Delatour, Chiara Scaramuzzino, Laurent Venance, Frédéric Saudou

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Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model by Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R. Hayden, Frédéric Saudou

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Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice by Yann Ehinger, Julie Bruyère, Nicolas Panayotis, Yah‐Se Abada, Emilie Borloz, Valérie Matagne, Chiara Scaramuzzino, Hélène Vitet, Benoit Delatour, Lydia Saidi, Laurent Villard, Frédéric Saudou, Jean‐Christophe Roux

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Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation by Trang Thi Minh Nguyen, Rudy Gadet, Marine Lanfranchi, Romane A. Lahaye, Sozerko Yandiev, Olivier Lohez, Ivan Mikaelian, Lea Jabbour, Ruth Rimokh, Julien Courchet, Frédéric Saudou, Nikolay Popgeorgiev, Germain Gillet

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Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin by Julie Bruyère, Yah-Se Abada, Hélène Vitet, Gaëlle Fontaine, Jean-Christophe Deloulme, Aurélia Cès, Eric Denarier, Karin Pernet-Gallay, Annie Andrieux, Sandrine Humbert, Marie-Claude Potier, Benoît Delatour, Frédéric Saudou

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A pathogenic proteolysis–resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function by Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song

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