Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: a panel discussion by Pamela Fernainy, Alan A. Cohen, Eleanor Murray, Elena Losina, Francois Lamontagne, Nadia Sourial

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Correction: Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: a panel discussion by Pamela Fernainy, Alan A. Cohen, Eleanor Murray, Elena Losina, Francois Lamontagne, Nadia Sourial

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Serum Concentration at 24 h With Intensive Beta-Lactam Therapy in Sepsis and Septic Shock: A Prospective Study by Evelyne Thériault, Massilia Benali, Samuel Starnino, Hugues Blain, Nicolas Goettel, Bianca Beloin-Jubinville, Amélie Marsot, Francois Lamontagne

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Drug-induced sleep endoscopy compared with systematic adenotonsillectomy in the management of obstructive sleep apnoea in children: a systematic review and meta-analysis protocol by Francois Lamontagne, Anne-Sophie Prévost, Mathieu Hylands, Mireille Gervais, Jean-Paul Praud, Marie-Claude Battista, Stéphanie Déziel-Malouin, Monia Lachance

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Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers by Erblin Cani, Jennifer L. Y. Tsang, Alexandra Binnie, Claudia C. dos Santos, Robert Fowler, Francois Lamontagne, Sangeeta Mehta, Patricia C. Liaw

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Pharmacological interventions for agitated behaviours in patients with traumatic brain injury: a systematic review by Sangeeta Mehta, David Williamson, Anne Julie Frenette, Lisa D Burry, Marc Perreault, Emmanuel Charbonney, Francois Lamontagne, Marie-Julie Potvin, Jean-Francois Giguère, Francis Bernard

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Inconsistent definitions for intention-to-treat in relation to missing outcome data: systematic review of the methods literature. by Mohamad Alshurafa, Matthias Briel, Elie A Akl, Ted Haines, Paul Moayyedi, Stephen J Gentles, Lorena Rios, Chau Tran, Neera Bhatnagar, Francois Lamontagne, Stephen D Walter, Gordon H Guyatt

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Corticosteroid Therapy in Critical Illness due to Seasonal and Pandemic Influenza by Philippe Yale, Neill KJ Adhikari, Vincent Masse, Robert A Fowler, Wei Xiong, Allison McGeer, Darlene Cann, Wallis Rudnick, Karen Green, Maureen O Meade, Louis Valiquette, François Lamontagne

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Administration of Parenteral Vitamin C in Patients With Severe Infection: Protocol for a Systematic Review and Meta-analysis by Arnav Agarwal, John Basmaji, Shannon M Fernando, Fang Zhou Ge, Yingqi Xiao, Haseeb Faisal, Kimia Honarmand, Mathieu Hylands, Vincent I Lau, Kimberley Lewis, Rachel Couban, François Lamontagne, Neill KJ Adhikari

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Low-value clinical practices in adult traumatic brain injury: an umbrella review protocol by Belinda J Gabbe, Henry Thomas Stelfox, Patrick Archambault, François Lauzier, Fiona Lecky, Francois Lamontagne, Michaël Chasse, Pier-Alexandre Tardif, Lynne Moore, Imen Farhat, John Kortbeek, Paule Lessard-Bonaventure, Catherine Truchon, Alexis F Turgeon

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A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial by Fernando G. Zampieri, Bruno R. da Costa, Suvi T. Vaara, François Lamontagne, Bram Rochwerg, Alistair D. Nichol, Shay McGuinness, Danny F. McAuley, Marlies Ostermann, Ron Wald, Sean M. Bagshaw, STARRT-AKI Investigators

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Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19: systematic review and network meta-analysis by Gordon Guyatt, Bram Rochwerg, Tahira Devji, Dena Zeraatkar, Anila Qasim, Thomas Agoritsas, Francois Lamontagne, Ariel Izcovich, Assem M Khamis, Romina Brignardello-Petersen, Elena Kum, Reed Alexander Cunningham Siemieniuk, Juan Pablo Díaz Martínez, Per Vandvik, Ellen Cusano, Sophia Mangala, Jessica Julia Bartoszko

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The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study. by Rachel D Savage, Robert A Fowler, Asgar H Rishu, Sean M Bagshaw, Deborah Cook, Peter Dodek, Richard Hall, Anand Kumar, François Lamontagne, François Lauzier, John Marshall, Claudio M Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Henry T Stelfox, Nick Daneman

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Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial by K. E. A. Burns, Leena Rizvi, Deborah J. Cook, Andrew J. E. Seely, Bram Rochwerg, Francois Lamontagne, John W. Devlin, Peter Dodek, Michael Mayette, Maged Tanios, Audrey Gouskos, Phyllis Kay, Susan Mitchell, Kenneth C. Kiedrowski, Nicholas S. Hill, For the Canadian Critical Care Trials Group

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Establishing Healthcare Worker Performance and Safety in Providing Critical Care for Patients in a Simulated Ebola Treatment Unit: Non-Randomized Pilot Study by Peter Kiiza, Sarah I. Mullin, Koren Teo, Len Goodman, Adic Perez, Ruxandra Pinto, Kelly Thompson, Dominique Piquette, Trevor Hall, Elhadj I. Bah, Michael Christian, Jan J. Hajek, Raymond Kao, François Lamontagne, John C. Marshall, Sharmistha Mishra, Srinivas Murthy, Abel Vanderschuren, Robert A. Fowler, Neill K. J. Adhikari

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Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19: a systematic review by Arnav Agarwal, Bram Rochwerg, Karen EA Burns, Rachel Couban, Srinivas Murthy, Francois Lamontagne, Shannon M Fernando, Janet Diaz, Dipayan Chaudhuri, John Basmaji, Kimia Honarmand, David S Hui, Per O Vandvik, Neill K J Adhikari, Fiona Muttalib, Samira Mubareka, Layla Bakaa, Sonia Brar, David Granton, Devin Chetan, Malini Hu, Charles D Gomersall

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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial by Michael Walsh, Salim Yusuf, Chirag Parikh, Jessica Vincent, P J Devereaux, Francois Lamontagne, Matthew T V Chan, Richard Whitlock, Meaghan Cuerden, Amit X Garg, Andre Lamy, Daniel I Sessler, Kevin Teoh, Ainslie Hildebrand, Yunxia Zuo, Pallav Shah, Seyed Hesameddin Abbasi, Mackenzie Quantz, Jean-Pierre Yared, Nicolas Noiseux, Georgios Tagarakis, Antoine Rochon, Janice Pogue, Abbas Salehiomran

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Methylene Blue in Septic Shock: A Systematic Review and Meta-Analysis by Shannon M. Fernando, MD, Alexandre Tran, MD, Karim Soliman, MD, Barbara Flynn, BScRN, Thomas Oommen, PharmD, Li Wenzhe, MD, Neill K.J. Adhikari, MDCM, Salmaan Kanji, PharmD, Andrew J.E. Seely, MD, PhD, Alison E. Fox-Robichaud, MD, Randy S. Wax, MD, FCCM, Deborah J. Cook, MD, François Lamontagne, MD, Bram Rochwerg, MD, FCCM

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Prediction of RECRUITment In randomized clinical Trials (RECRUIT-IT)—rationale and design for an international collaborative study by Benjamin Kasenda, Junhao Liu, Yu Jiang, Byron Gajewski, Cen Wu, Erik von Elm, Stefan Schandelmaier, Giusi Moffa, Sven Trelle, Andreas Michael Schmitt, Amanda K. Herbrand, Viktoria Gloy, Benjamin Speich, Sally Hopewell, Lars G. Hemkens, Constantin Sluka, Kris McGill, Maureen Meade, Deborah Cook, Francois Lamontagne, Jean-Marc Tréluyer, Anna-Bettina Haidich, John P. A. Ioannidis, Shaun Treweek, Matthias Briel

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Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic by Julie C. Reid, Alex Molloy, Geoff Strong, Laurel Kelly, Heather O’Grady, Deborah Cook, Patrick M. Archambault, Ian Ball, Sue Berney, Karen E. A. Burns, Frederick D’Aragon, Erick Duan, Shane W. English, François Lamontagne, Amy M. Pastva, Bram Rochwerg, Andrew J. E. Seely, Karim Serri, Jennifer L. Y. Tsang, Avelino C. Verceles, Brenda Reeve, Alison Fox-Robichaud, John Muscedere, Margaret Herridge, Lehana Thabane, Michelle E. Kho, on behalf of the CYCLE Investigators

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