Editorial: Secondary Metabolites and Peptides as Unique Natural Reservoirs of New Therapeutic Leads for Treatment of Cancer and Microbial Infections by Maria Luisa Mangoni, Anirban Bhunia, Bruno Botta, Francesca Ghirga

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Synthesis of indolo[1,2-c]quinazolines from 2-alkynylaniline derivatives through Pd-catalyzed indole formation/cyclization with N,N-dimethylformamide dimethyl acetal by Antonio Arcadi, Sandro Cacchi, Giancarlo Fabrizi, Francesca Ghirga, Antonella Goggiamani, Antonia Iazzetti, Fabio Marinelli

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Synthesis, Biosynthesis, and Biological Activity of Diels–Alder Adducts from <i>Morus</i> Genus: An Update by Carola Tortora, Luca Pisano, Valeria Vergine, Francesca Ghirga, Antonia Iazzetti, Andrea Calcaterra, Violeta Marković, Bruno Botta, Deborah Quaglio

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Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of <em>Staphylococcus aureus</em>-Induced Infections by Bruno Casciaro, Andrea Calcaterra, Floriana Cappiello, Mattia Mori, Maria Rosa Loffredo, Francesca Ghirga, Maria Luisa Mangoni, Bruno Botta, Deborah Quaglio

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The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections by Floriana Cappiello, Maria Rosa Loffredo, Cristina Del Plato, Silvia Cammarone, Bruno Casciaro, Deborah Quaglio, Maria Luisa Mangoni, Bruno Botta, Francesca Ghirga

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The Pictet-Spengler Reaction Updates Its Habits by Andrea Calcaterra, Laura Mangiardi, Giuliano Delle Monache, Deborah Quaglio, Silvia Balducci, Simone Berardozzi, Antonia Iazzetti, Roberta Franzini, Bruno Botta, Francesca Ghirga

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Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia by Alessandro Falsini, Gaia Giuntini, Mattia Mori, Francesca Ghirga, Deborah Quaglio, Antonino Cucinotta, Federica Coppola, Irene Filippi, Antonella Naldini, Bruno Botta, Fabio Carraro

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Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases by Emilie Evain-Bana, Lucie Schiavo, Christophe Bour, Don Antoine Lanfranchi, Simone Berardozzi, Francesca Ghirga, Denyse Bagrel, Bruno Botta, Gilles Hanquet, Mattia Mori

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Selection of Natural Compounds with HMGA-Interfering Activities and Cancer Cell Cytotoxicity by Mattia Mori, Francesca Ghirga, Beatrice Amato, Luca Secco, Deborah Quaglio, Isabella Romeo, Marta Gambirasi, Alberta Bergamo, Sonia Covaceuszach, Riccardo Sgarra, Bruno Botta, Guidalberto Manfioletti

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Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds by Chiara Platella, Francesca Ghirga, Pasquale Zizza, Luca Pompili, Simona Marzano, Bruno Pagano, Deborah Quaglio, Valeria Vergine, Silvia Cammarone, Bruno Botta, Annamaria Biroccio, Mattia Mori, Daniela Montesarchio

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Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections by Bruno Casciaro, Laura Mangiardi, Floriana Cappiello, Isabella Romeo, Maria Rosa Loffredo, Antonia Iazzetti, Andrea Calcaterra, Antonella Goggiamani, Francesca Ghirga, Maria Luisa Mangoni, Bruno Botta, Deborah Quaglio

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The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria by Bruno Casciaro, Francesca Ghirga, Floriana Cappiello, Valeria Vergine, Maria Rosa Loffredo, Silvia Cammarone, Elena Puglisi, Carola Tortora, Deborah Quaglio, Mattia Mori, Bruno Botta, Maria Luisa Mangoni

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Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 by Andrea Calcaterra, Valentina Iovine, Bruno Botta, Deborah Quaglio, Ilaria D’Acquarica, Alessia Ciogli, Antonia Iazzetti, Romina Alfonsi, Ludovica Lospinoso Severini, Paola Infante, Lucia Di Marcotullio, Mattia Mori, Francesca Ghirga

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Ferritin nanocage-enabled detection of pathological tau in living human retinal cells by Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio

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Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone by María Balsera-Manzanero, Francesca Ghirga, Ana Ruiz-Molina, Mattia Mori, Jerónimo Pachón, Jerónimo Pachón, Bruno Botta, Elisa Cordero, Elisa Cordero, Elisa Cordero, Deborah Quaglio, Javier Sánchez-Céspedes, Javier Sánchez-Céspedes

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Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia by Mattia Mori, Luca Tottone, Deborah Quaglio, Nadezda Zhdanovskaya, Cinzia Ingallina, Marisa Fusto, Francesca Ghirga, Giovanna Peruzzi, Maria Elisa Crestoni, Fabrizio Simeoni, Francesca Giulimondi, Claudio Talora, Bruno Botta, Isabella Screpanti, Rocco Palermo

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Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity by Mattia Mori, Deborah Quaglio, Andrea Calcaterra, Francesca Ghirga, Leonardo Sorrentino, Silvia Cammarone, Matteo Fracella, Alessandra D’Auria, Federica Frasca, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Bruno Botta, Guido Antonelli, Alessandra Pierangeli, Carolina Scagnolari

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A Multimethodological Characterization of <i>Cannabis sativa</i> L. Inflorescences from Seven Dioecious Cultivars Grown in Italy: The Effect of Different Harvesting Stages by Mattia Spano, Giacomo Di Matteo, Cinzia Ingallina, Bruno Botta, Deborah Quaglio, Francesca Ghirga, Silvia Balducci, Silvia Cammarone, Enio Campiglia, Anna Maria Giusti, Giuliana Vinci, Mattia Rapa, Salvatore Ciano, Luisa Mannina, Anatoly P. Sobolev

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Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons by Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boffi

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1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma by Giuseppina D’Alessandro, Deborah Quaglio, Lucia Monaco, Clotilde Lauro, Francesca Ghirga, Cinzia Ingallina, Michela De Martino, Sergio Fucile, Alessandra Porzia, Maria Amalia Di Castro, Federica Bellato, Francesca Mastrotto, Mattia Mori, Paola Infante, Paola Turano, Stefano Salmaso, Paolo Caliceti, Lucia Di Marcotullio, Bruno Botta, Veronica Ghini, Cristina Limatola

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