RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives by Marco Infante, Alessandra Fabi, Francesco Cognetti, Stefania Gorini, Massimiliano Caprio, Andrea Fabbri

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The immersive experience of virtual reality during chemotherapy in patients with early breast and ovarian cancers: The patient’s dream study by Alessandra Fabi, Luana Fotia, Federico Giuseppini, Arianna Gaeta, Chiara Falcicchio, Gabriele Giuliani, Antonella Savarese, Emanuela Taraborelli, Valentina Rossi, Paola Malaguti, Diana Giannarelli, Patrizia Pugliese, Francesco Cognetti, Francesco Cognetti

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Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy by Italia Falcone, Fabiana Conciatori, Chiara Bazzichetto, Gianluigi Ferretti, Francesco Cognetti, Ludovica Ciuffreda, Michele Milella

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KRAS early testing: consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an Italian setting. by Carlo Barone, Carmine Pinto, Nicola Normanno, Lorenzo Capussotti, Francesco Cognetti, Alfredo Falcone, Lorenzo Mantovani

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Case Report: Rechallenge With BRAF and MEK Inhibitors in Metastatic Melanoma: A Further Therapeutic Option in Salvage Setting? by Anna Stagno, Sabrina Vari, Alessio Annovazzi, Vincenzo Anelli, Michelangelo Russillo, Francesco Cognetti, Virginia Ferraresi

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mTOR Cross-Talk in Cancer and Potential for Combination Therapy by Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti, Michele Milella

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PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise? by Chiara Bazzichetto, Fabiana Conciatori, Matteo Pallocca, Italia Falcone, Maurizio Fanciulli, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda

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PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy by Fabiana Conciatori, Chiara Bazzichetto, Italia Falcone, Ludovica Ciuffreda, Gianluigi Ferretti, Sabrina Vari, Virginia Ferraresi, Francesco Cognetti, Michele Milella

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Oligometastatic Breast Cancer: How to Manage It? by Vittoria Barberi, Antonella Pietragalla, Gianluca Franceschini, Fabio Marazzi, Ida Paris, Francesco Cognetti, Riccardo Masetti, Giovanni Scambia, Alessandra Fabi

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AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations by Italia Falcone, Fabiana Conciatori, Chiara Bazzichetto, Emilio Bria, Luisa Carbognin, Paola Malaguti, Gianluigi Ferretti, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda

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A Rare Case of Pituitary Melanoma Metastasis: A Dramatic and Prolonged Response to Dabrafenib-Trametinib Therapy by Marilda Mormando, Giulia Puliani, Giulia Puliani, Agnese Barnabei, Rosa Lauretta, Marta Bianchini, Alfonsina Chiefari, Michelangelo Russillo, Francesco Cognetti, Luisa Romano, Marialuisa Appetecchia

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Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology by Chiara Bazzichetto, Claudio Luchini, Fabiana Conciatori, Vanja Vaccaro, Ilaria Di Cello, Paola Mattiolo, Italia Falcone, Gianluigi Ferretti, Aldo Scarpa, Francesco Cognetti, Michele Milella

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Precision Medicine and Melanoma: Multi-Omics Approaches to Monitoring the Immunotherapy Response by Fabio Valenti, Italia Falcone, Sara Ungania, Flora Desiderio, Patrizio Giacomini, Chiara Bazzichetto, Fabiana Conciatori, Enzo Gallo, Francesco Cognetti, Gennaro Ciliberto, Aldo Morrone, Antonino Guerrisi

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Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition by Fabiana Conciatori, Fabiana Conciatori, Erica Salvati, Ludovica Ciuffreda, Senji Shirasawa, Italia Falcone, Francesco Cognetti, Gianluigi Ferretti, Massimo Zeuli, Donatella Del Bufalo, Chiara Bazzichetto, Chiara Bazzichetto, Michele Milella

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From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer by Chiara Bazzichetto, Fabiana Conciatori, Claudio Luchini, Francesca Simionato, Raffaela Santoro, Vanja Vaccaro, Vincenzo Corbo, Italia Falcone, Gianluigi Ferretti, Francesco Cognetti, Davide Melisi, Aldo Scarpa, Ludovica Ciuffreda, Michele Milella

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Exploring CT Texture Parameters as Predictive and Response Imaging Biomarkers of Survival in Patients With Metastatic Melanoma Treated With PD-1 Inhibitor Nivolumab: A Pilot Study... by Antonino Guerrisi, Michelangelo Russillo, Emiliano Loi, Balaji Ganeshan, Sara Ungania, Flora Desiderio, Vicente Bruzzaniti, Italia Falcone, Davide Renna, Virginia Ferraresi, Mauro Caterino, Francesco Maria Solivetti, Francesco Cognetti, Aldo Morrone

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Should All Patients With HR-Positive HER2-Negative Metastatic Breast Cancer Receive CDK 4/6 Inhibitor As First-Line Based Therapy? A Network Meta-Analysis of Data from the PALOMA 2... by Valentina Rossi, Paola Berchialla, Diana Giannarelli, Cecilia Nisticò, Gianluigi Ferretti, Simona Gasparro, Michelangelo Russillo, Giovanna Catania, Leonardo Vigna, Rossella Letizia Mancusi, Emilio Bria, Filippo Montemurro, Francesco Cognetti, Alessandra Fabi

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Nutraceuticals and Cancer: Potential for Natural Polyphenols by Jessica Maiuolo, Micaela Gliozzi, Cristina Carresi, Vincenzo Musolino, Francesca Oppedisano, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Roberta Macri, Stefano Ruga, Antonio Cardamone, Annarita Coppoletta, Annachiara Mollace, Francesco Cognetti, Vincenzo Mollace

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Growth-Inhibitory and Antiangiogenic Activity of the MEK Inhibitor PD0325901 in Malignant Melanoma with or without BRAF Mutations by Ludovica Ciuffreda, Donatella Del Bufalo, Marianna Desideri, Cristina Di Sanza, Antonella Stoppacciaro, Maria Rosaria Ricciardi, Sabina Chiaretti, Simona Tavolaro, Barbara Benassi, Alfonso Bellacosa, Robin Foà, Agostino Tafuri, Francesco Cognetti, Andrea Anichini, Gabriella Zupi, Michele Milella

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A 17-Gene Expression Signature for Early Identification of Poor Prognosis in Clear Cell Renal Cell Carcinoma by Maria Bassanelli, Marina Borro, Michela Roberto, Diana Giannarelli, Silvana Giacinti, Simona Di Martino, Anna Ceribelli, Andrea Russo, Annamaria Aschelter, Stefania Scarpino, Andrea Montori, Edoardo Pescarmona, Silverio Tomao, Maurizio Simmaco, Francesco Cognetti, Michele Milella, Paolo Marchetti

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