Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores by Gunnar Elke, Frank Bloos, Darius Cameron Wilson, Patrick Meybohm, the SepNet Critical Care Trials Group

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(1,3)-β-D-glucan-based diagnosis of invasive Candida infection versus culture-based diagnosis in patients with sepsis and with an increased risk of invasive Candida infection (Cand... by Frank Bloos, Jürgen Held, Peter Schlattmann, Nicole Brillinger, Oliver Kurzai, Oliver A. Cornely, Daniel Thomas-Rüddel

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Collaborative Semantic Annotation Tooling (CoAT) to Improve Efficiency and Plug-and-Play Semantic Interoperability in the Secondary Use of Medical Data: Concept, Implementation, an... by Thomas Wiktorin, Daniel Grigutsch, Felix Erdfelder, Andrew J. Heidel, Frank Bloos, Danny Ammon, Matthias Löbe, Sven Zenker

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Infliximab in the treatment of patients with severe COVID-19 (INFLIXCOVID): protocol for a randomised, controlled, multicentre, open-label phase II clinical study by Sina M. Coldewey, Charles Neu, Frank Bloos, Philipp Baumbach, Ulrike Schumacher, Michael Bauer, Philipp Reuken, Andreas Stallmach

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Predicting the requirement for renal replacement therapy in intensive care patients with sepsis by Axel Nierhaus, Frank Bloos, Darius Cameron Wilson, Gunnar Elke, Patrick Meybohm, the SepNet Critical Care Trials Group

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Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions by Teresa Lehnert, Ines Leonhardt, Sandra Timme, Daniel Thomas-Rüddel, Frank Bloos, Christoph Sponholz, Oliver Kurzai, Marc Thilo Figge, Kerstin Hünniger

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Evaluation of a polymerase chain reaction assay for pathogen detection in septic patients under routine condition: an observational study. by Frank Bloos, Svea Sachse, Andreas Kortgen, Mathias W Pletz, Marc Lehmann, Eberhard Straube, Niels C Riedemann, Konrad Reinhart, Michael Bauer

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Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled tri... by Hendrik Rüddel, Daniel O. Thomas-Rüddel, Konrad Reinhart, Friedhelm Bach, Herwig Gerlach, Matthias Lindner, John C. Marshall, Philipp Simon, Manfred Weiss, Frank Bloos, Daniel Schwarzkopf, the MEDUSA study group

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Skin dysbiosis and loss of microbiome site specificity in critically ill patients by Tilman E. Klassert, Cristina Zubiria-Barrera, Luisa Denkel, Robert Neubert, Antony Schneegans, Aylina Kulle, Antje Vester, Frank Bloos, Christian Schulze, Jörg Epstude, Petra Gastmeier, Christine Geffers, Hortense Slevogt

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The prevalence of sepsis-induced coagulopathy in patients with sepsis – a secondary analysis of two German multicenter randomized controlled trials by Thomas Schmoch, Patrick Möhnle, Markus A. Weigand, Josef Briegel, Michael Bauer, Frank Bloos, Patrick Meybohm, Didier Keh, Markus Löffler, Gunnar Elke, Thorsten Brenner, Holger Bogatsch, for the SepNet–Critical Care Trials Group

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Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants by Henrike Maaß, Mario Ynga-Durand, Marko Milošević, Fran Krstanović, Marina Pribanić Matešić, Iva Žuža, Stipan Jonjić, Ilija Brizić, Alan Šustić, Frank Bloos, SepNet Critical Care Trials Group, Alen Protić, Luka Čičin-Šain

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The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage by Mohamed Ghait, Shivalee N. Duduskar, Michael Rooney, Michael Rooney, Norman Häfner, Laura Reng, Bianca Göhrig, Philipp A. Reuken, Frank Bloos, Michael Bauer, Michael Bauer, Christoph Sponholz, Tony Bruns, Tony Bruns, Ignacio Rubio, Ignacio Rubio

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The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial by Gunnar Elke, Frank Bloos, Darius Cameron Wilson, Frank Martin Brunkhorst, Josef Briegel, Konrad Reinhart, Markus Loeffler, Stefan Kluge, Axel Nierhaus, Ulrich Jaschinski, Onnen Moerer, Andreas Weyland, Patrick Meybohm, the SepNet Critical Care Trials Group

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A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis by Daniel Schwarzkopf, Claudia Tanja Matthaeus-Kraemer, Daniel O. Thomas-Rüddel, Hendrik Rüddel, Bernhard Poidinger, Friedhelm Bach, Herwig Gerlach, Matthias Gründling, Matthias Lindner, Christian Scheer, Philipp Simon, Manfred Weiss, Konrad Reinhart, Frank Bloos, MEDUSA study group

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Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature by Daniel O. Thomas-Rüddel, Peter Hoffmann, Daniel Schwarzkopf, Christian Scheer, Friedhelm Bach, Marcus Komann, Herwig Gerlach, Manfred Weiss, Matthias Lindner, Hendrik Rüddel, Philipp Simon, Sven-Olaf Kuhn, Reinhard Wetzker, Michael Bauer, Konrad Reinhart, Frank Bloos, the MEDUSA study group

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New, Useful Criteria for Assessing the Evidence of Infection in Sepsis Research by Lisa Mellhammar, MD, PhD, Sixten Elén, BsC, Simone Ehrhard, MD, Hjalmar Bouma, MD, PhD, Lorenz Ninck, BsC, Eva Muntjewerff, BsC, Daniel Wünsch, MD, Frank Bloos, MD, PhD, Erik Malmström, MD, PhD, Adam Linder, MD, PhD

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Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis by Anuradha Ramoji, PhD, Daniel Thomas-Rüddel, MD, Oleg Ryabchykov, PhD, Michael Bauer, MD, Natalie Arend, MSc, Evangelos J. Giamarellos-Bourboulis, MD, Jesper Eugen-Olsen, PhD, Michael Kiehntopf, MD, Thomas Bocklitz, PhD, Jürgen Popp, PhD, Frank Bloos, MD, PhD, Ute Neugebauer, PhD

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Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortalityResearch in context by Evangelos J. Giamarellos-Bourboulis, Massimo Antonelli, Frank Bloos, Ioanna Kotsamidi, Christos Psarrakis, Konstantina Dakou, Daniel Thomas-Rüddel, Luca Montini, Josef Briegel, Georgia Damoraki, Panagiotis Koufargyris, Souzana Anisoglou, Eleni Antoniadou, Glykeria Vlachogianni, Christos Tsiantas, Matteo Masullo, Aikaterini Ioakeimidou, Eumorfia Kondili, Maria Ntaganou, Eleni Gkeka, Vassileios Papaioannou, Effie Polyzogopoulou, Armin J. Reininger, Gennaro De Pascale, Michael Kiehntopf, Eleni Mouloudi, Michael Bauer

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Patterns of intravenous fluid resuscitation use in adult intensive care patients between 2007 and 2014: An international cross-sectional study. by Naomi E Hammond, Colman Taylor, Simon Finfer, Flavia R Machado, YouZhong An, Laurent Billot, Frank Bloos, Fernando Bozza, Alexandre Biasi Cavalcanti, Maryam Correa, Bin Du, Peter B Hjortrup, Yang Li, Lauralyn McIntryre, Manoj Saxena, Frédérique Schortgen, Nicola R Watts, John Myburgh, Fluid-TRIPS and Fluidos Investigators, George Institute for Global Health, The ANZICS Clinical Trials Group, BRICNet, and the REVA research Network

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Efficacy and Safety of Vilobelimab (IFX-1), a Novel Monoclonal Anti-C5a Antibody, in Patients With Early Severe Sepsis or Septic Shock—A Randomized, Placebo-Controlled, Double-Blin... by Michael Bauer, MD, Andreas Weyland, MD, Gernot Marx, MD, Frank Bloos, MD, PhD, Stephan Weber, Dipl. Stat., Norbert Weiler, MD, Stefan Kluge, MD, Anja Diers, MD, Tim Philipp Simon, MD, Ingmar Lautenschläger, MD, Matthias Gründling, MD, Ulrich Jaschinski, MD, Philipp Simon, MD, Axel Nierhaus, MD, Onnen Moerer, MD, Lorenz Reill, MD, Achim Jörres, MD, Renfeng Guo, MD, Markus Loeffler, MD, Konrad Reinhart, MD, Niels Riedemann, MD, for the SepNet-Study Group

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