Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation. by Saman Amini, Frank C P Holstege, Patrick Kemmeren

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An Optimized Chromatin Immunoprecipitation Protocol for Quantification of Protein-DNA Interactions by Wim J. de Jonge, Mariël Brok, Patrick Kemmeren, Frank C.P. Holstege

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High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8. by Maria J Aristizabal, Gian Luca Negri, Joris J Benschop, Frank C P Holstege, Nevan J Krogan, Michael S Kobor

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The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interact... by Saman Amini, Annika Jacobsen, Olga Ivanova, Philip Lijnzaad, Jaap Heringa, Frank C P Holstege, K Anton Feenstra, Patrick Kemmeren

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Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice. by Heidi M B Lesscher, Julia M Houthuijzen, Marian J Groot Koerkamp, Frank C P Holstege, Louk J M J Vanderschuren

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A systematic analysis of genetic interactions and their underlying biology in childhood cancer by Josephine T. Daub, Saman Amini, Denise J. E. Kersjes, Xiaotu Ma, Natalie Jäger, Jinghui Zhang, Stefan M. Pfister, Frank C. P. Holstege, Patrick Kemmeren

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Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development by Koushik Chakrabarty, Lars Von Oerthel, Anita Hellemons, Frédéric Clotman, Agnès Espana, Marian Groot Koerkamp, Frank C. P. Holstege, R. Jeroen Pasterkamp, Marten P. Smidt

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A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover. by Kitty F Verzijlbergen, Tibor van Welsem, Daoud Sie, Tineke L Lenstra, Daniel J Turner, Frank C P Holstege, Ron M Kerkhoven, Fred van Leeuwen

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The role of Ctk1 kinase in termination of small non-coding RNAs. by Tineke L Lenstra, Agnieszka Tudek, Sandra Clauder, Zhenyu Xu, Spyridon T Pachis, Dik van Leenen, Patrick Kemmeren, Lars M Steinmetz, Domenico Libri, Frank C P Holstege

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Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II. by Dominik M Meinel, Cornelia Burkert-Kautzsch, Anja Kieser, Eoghan O'Duibhir, Matthias Siebert, Andreas Mayer, Patrick Cramer, Johannes Söding, Frank C P Holstege, Katja Sträßer

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Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. by Jerome Korzelius, Inge The, Suzan Ruijtenberg, Martine B W Prinsen, Vincent Portegijs, Teije C Middelkoop, Marian J Groot Koerkamp, Frank C P Holstege, Mike Boxem, Sander van den Heuvel

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Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. by Thanasis Margaritis, Vincent Oreal, Nathalie Brabers, Laetitia Maestroni, Adeline Vitaliano-Prunier, Joris J Benschop, Sander van Hooff, Dik van Leenen, Catherine Dargemont, Vincent Géli, Frank C P Holstege

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Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function by Nikolay S. Outchkourov, Jose M. Muiño, Kerstin Kaufmann, Wilfred F.J. van IJcken, Marian J. Groot Koerkamp, Dik van Leenen, Petra de Graaf, Frank C.P. Holstege, Frank G. Grosveld, H.T. Marc Timmers

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Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. by Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee

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Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. by Frank G van Steenbeek, Bart Spee, Louis C Penning, Anne Kummeling, Ingrid H M van Gils, Guy C M Grinwis, Dik Van Leenen, Frank C P Holstege, Manon Vos-Loohuis, Jan Rothuizen, Peter A J Leegwater

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PDGFRB Promotes Liver Metastasis Formation of Mesenchymal-Like Colorectal Tumor Cells by Ernst J.A. Steller, Danielle A. Raats, Jan Koster, Bert Rutten, Klaas M. Govaert, Benjamin L. Emmink, Nikol Snoeren, Sander R. van Hooff, Frank C.P. Holstege, Coen Maas, Rinkes Inne H.M. Borel, Onno Kranenburg

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Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases. by Loes A L van de Pasch, Antony J Miles, Wilco Nijenhuis, Nathalie A C H Brabers, Dik van Leenen, Philip Lijnzaad, Markus K Brown, Jimmy Ouellet, Yves Barral, Geert J P L Kops, Frank C P Holstege

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Targeted locus amplification to develop robust patient-specific assays for liquid biopsies in pediatric solid tumors by Lieke M. J. van Zogchel, Lieke M. J. van Zogchel, Nathalie S. M. Lak, Nathalie S. M. Lak, Nina U. Gelineau, Nina U. Gelineau, Irina Sergeeva, Ellen Stelloo, Joost Swennenhuis, Harma Feitsma, Max van Min, Erik Splinter, Margit Bleijs, Marian Groot Koerkamp, Willemijn Breunis, Willemijn Breunis, Michael Torsten Meister, Michael Torsten Meister, Waleed Hassan Kholossy, Frank C. P. Holstege, Frank C. P. Holstege, Jan J. Molenaar, Wendy W. J. de Leng, Janine Stutterheim, C. Ellen van der Schoot, Godelieve A. M. Tytgat

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Systematic Triple-Mutant Analysis Uncovers Functional Connectivity between Pathways Involved in Chromosome Regulation by James E. Haber, Hannes Braberg, Qiuqin Wu, Richard Alexander, Julian Haase, Colm Ryan, Zach Lipkin-Moore, Kathleen E. Franks-Skiba, Tasha Johnson, Michael Shales, Tineke L. Lenstra, Frank C.P. Holstege, Jeffrey R. Johnson, Kerry Bloom, Nevan J. Krogan

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Expression Profiling after Prolonged Experimental Febrile Seizures in Mice Suggests Structural Remodeling in the Hippocampus. by Bart C Jongbloets, Koen L I van Gassen, Anne A Kan, Anneke H O Olde Engberink, Marina de Wit, Inge G Wolterink-Donselaar, Marian J A Groot Koerkamp, Onno van Nieuwenhuizen, Frank C P Holstege, Pierre N E de Graan

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