Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology. by Nicholas A Castello, Kim N Green, Frank M LaFerla

Get full text

Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. by Anna Parachikova, Kim N Green, Curt Hendrix, Frank M LaFerla

Get full text

Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling by Malcolm A. Leissring, Frank M. LaFerla, Nick Callamaras, Ian Parker

Get full text

Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model. by Kristoffer Myczek, Stephen T Yeung, Nicholas Castello, David Baglietto-Vargas, Frank M LaFerla

Get full text

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease by Meredith A. Chabrier, David Cheng, Nicholas A. Castello, Kim N. Green, Frank M. LaFerla

Get full text

A Dual-Function “TRE-Lox” System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D by Heather M. Terron, Derek S. Maranan, Luke A. Burgard, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring

Get full text

BrightFocus Alzheimer’s Fast Track 2019 by Keith W. Whitaker, Frank M. LaFerla, Harry W. M. Steinbusch, Cynthia A. Lemere, Diane E. Bovenkamp

Get full text

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis by Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu

Get full text

7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. by Nicholas A Castello, Michael H Nguyen, Jenny D Tran, David Cheng, Kim N Green, Frank M LaFerla

Get full text

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease by Veerendra Kumar Madala Halagappa, Zhihong Guo, Michelle Pearson, Yasuji Matsuoka, Roy G. Cutler, Frank M. LaFerla, Mark P. Mattson

Get full text

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease by Syed Faraz Kazim, Julie Blanchard, Chun-Ling Dai, Yunn-Chyn Tung, Frank M. LaFerla, Inge-Grundke Iqbal, Khalid Iqbal

Get full text

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar olig... by Justyna Sosna, Stephan Philipp, Ricardo Albay, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M. LaFerla, Charles G. Glabe

Get full text

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. by Tobias Bittner, Martin Fuhrmann, Steffen Burgold, Simon M Ochs, Nadine Hoffmann, Gerda Mitteregger, Hans Kretzschmar, Frank M LaFerla, Jochen Herms

Get full text

Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. by José J Rodríguez, Victoria C Jones, Masashi Tabuchi, Stuart M Allan, Elysse M Knight, Frank M LaFerla, Salvatore Oddo, Alexei Verkhratsky

Get full text

Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice by Lani K. Clinton, Lauren M. Billings, Kim N. Green, Antonella Caccamo, Jerry Ngo, Salvatore Oddo, James L. McGaugh, Frank M. LaFerla

Get full text

Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. by Xiao-Xin Yan, Yan Cai, Jarod Shelton, Si-Hao Deng, Xue-Gang Luo, Salvatore Oddo, Frank M Laferla, Huaibin Cai, Gregory M Rose, Peter R Patrylo

Get full text

Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models by Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah, Frank M. LaFerla

Get full text

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease. by Yanxing Chen, Zhu Tian, Zhihou Liang, Shenggang Sun, Chun-Ling Dai, Moon H Lee, Frank M LaFerla, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong

Get full text

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis by Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring

Get full text

The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides. by Federico T Bianchi, Paola Camera, Ugo Ala, Daniele Imperiale, Antonio Migheli, Enrica Boda, Filippo Tempia, Gaia Berto, Ylenia Bosio, Salvatore Oddo, Frank M LaFerla, Stefano Taraglio, Carlos G Dotti, Ferdinando Di Cunto

Get full text