Crystal structures of the catalytic domain of human soluble guanylate cyclase. by Charles K Allerston, Frank von Delft, Opher Gileadi

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Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening by Sabrina R. Mackinnon, Gustavo A. Bezerra, Tobias Krojer, Tamas Szommer, Tamas Szommer, Frank von Delft, Frank von Delft, Paul E. Brennan, Paul E. Brennan, Wyatt W. Yue

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Learnt representations of proteins can be used for accurate prediction of small molecule binding sites on experimentally determined and predicted protein structures by Anna Carbery, Martin Buttenschoen, Rachael Skyner, Frank von Delft, Charlotte M. Deane

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Galaxy workflows for fragment-based virtual screening: a case study on the SARS-CoV-2 main protease by Simon Bray, Tim Dudgeon, Rachael Skyner, Rolf Backofen, Björn Grüning, Frank von Delft

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Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites by Nicholas M. Pearce, Anthony R. Bradley, Tobias Krojer, Brian D. Marsden, Charlotte M. Deane, Frank von Delft

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Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. by Peter Rellos, Ashley C W Pike, Frank H Niesen, Eidarus Salah, Wen Hwa Lee, Frank von Delft, Stefan Knapp

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Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors by Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E. Brennan, Ivan Ahel

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Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. by Alex N Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit E Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

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An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering by Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, James S Fraser

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In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors by Jingxu Guo, Alice Douangamath, Weixiao Song, Alun R. Coker, A.W. Edith Chan, Steve P. Wood, Jonathan B. Cooper, Efrat Resnick, Nir London, Frank von Delft

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There is no market for new antibiotics: this allows an open approach to research and development [version 1; peer review: 2 approved] by Dana M. Klug, Fahima I. M. Idiris, Mark A. T. Blaskovich, Frank von Delft, Christopher G. Dowson, Claas Kirchhelle, Adam P. Roberts, Andrew C. Singer, Matthew H. Todd

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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density by Nicholas M. Pearce, Tobias Krojer, Anthony R. Bradley, Patrick Collins, Radosław P. Nowak, Romain Talon, Brian D. Marsden, Sebastian Kelm, Jiye Shi, Charlotte M. Deane, Frank von Delft

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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B by Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy

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Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni by Lauro Ribeiro de Souza Neto, Bogar Omar Montoya, José Brandão-Neto, Anil Verma, Sebastian Bowyer, José Teófilo Moreira-Filho, Rafael Ferreira Dantas, Bruno Junior Neves, Carolina Horta Andrade, Frank von Delft, Raymond J. Owens, Nicholas Furnham, Floriano Paes Silva-Jr

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Exploring protein hotspots by optimized fragment pharmacophores by Dávid Bajusz, Warren S. Wade, Grzegorz Satała, Andrzej J. Bojarski, Janez Ilaš, Jessica Ebner, Florian Grebien, Henrietta Papp, Ferenc Jakab, Alice Douangamath, Daren Fearon, Frank von Delft, Marion Schuller, Ivan Ahel, Amanda Wakefield, Sándor Vajda, János Gerencsér, Péter Pallai, György M. Keserű

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Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation by Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Mohammad Karaminejadranjbar, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank von Delft, Ahmed Ashour Ahmed

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Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation by Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Eli M. Carrami, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank von Delft, Ahmed Ashour Ahmed

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Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 by Martin A. Redhead, C. David Owen, Lennart Brewitz, Amelia H. Collette, Petra Lukacik, Claire Strain-Damerell, Sean W. Robinson, Patrick M. Collins, Philipp Schäfer, Mark Swindells, Chris J. Radoux, Iva Navratilova Hopkins, Daren Fearon, Alice Douangamath, Frank von Delft, Tika R. Malla, Laura Vangeel, Thomas Vercruysse, Jan Thibaut, Pieter Leyssen, Tu-Trinh Nguyen, Mitchell Hull, Anthony Tumber, David J. Hallett, Christopher J. Schofield, David I. Stuart, Andrew L. Hopkins, Martin A. Walsh

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease by Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh

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