Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q. by Frayling, I, Bodmer, W, Tomlinson, I

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas. by Beck, N, Tomlinson, I, Homfray, T, Frayling, I, Hodgson, S, Bodmer, W

Molecular testing for somatic cancer mutations: a survey of current and future testing in UK laboratories. by Wordsworth, S, Papanicolas, I, Buchanan, J, Frayling, I, Taylor, J, Tomlinson, I

Current and future molecular testing of cancers: A survey of UK laboratories by Papanicolas, I, Wordsworth, S, Buchanan, J, Taylor, J, Frayling, I, Tomlinson, I

Loss of heterozygosity at APC and beta-catenin expression in sporadic colorectal carcinogenesis by Hao, X, Frayling, I, Willcocks, T, Tomlinson, I, Pignatelli, M, Talbot, I

Molecular testing for somatic mutations in common cancers: the views of UK oncologists. by Wordsworth, S, Buchanan, J, Papanicolas, I, Taylor, J, Frayling, I, Tomlinson, I

Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria. by Beck, N, Tomlinson, I, Homfray, T, Frayling, I, Hodgson, S, Harocopos, C, Bodmer, W

Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. by Jeans, A, Frayling, I, Jasani, B, Side, L, Blesing, C, Ansorge, O

The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas. by Hao, X, Frayling, I, Sgouros, J, Du, M, Willcocks, T, Talbot, I, Tomlinson, I

Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis. by Hao, X, Frayling, I, Willcocks, T, Han, W, Tomlinson, I, Pignatelli, M, Pretlow, T, Talbot, I

Colorectal cancer stratification in the routine clinical pathway: A district general hospital experience by Wedden, S, Miller, K, Frayling, I, Thomas, T, Chefani, A, Miller, K, Hamblin, A, Taylor, J, D'Arrigo, C

Germline PTEN mutations in Cowden syndrome-like families. by Marsh, D, Dahia, P, Caron, S, Kum, J, Frayling, I, Tomlinson, I, Hughes, K, Eeles, R, Hodgson, S, Murday, V, Houlston, R, Eng, C

The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. by Frayling, I, Beck, N, Ilyas, M, Dove-Edwin, I, Goodman, P, Pack, K, Bell, J, Williams, C, Hodgson, S, Thomas, H, Talbot, I, Bodmer, W, Tomlinson, I

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22. by Tomlinson, I, Rahman, N, Frayling, I, Mangion, J, Barfoot, R, Hamoudi, R, Seal, S, Northover, J, Thomas, H, Neale, K, Hodgson, S, Talbot, I, Houlston, R, Stratton, MR

Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium. by Woodford-Richens, K, Williamson, J, Bevan, S, Young, J, Leggett, B, Frayling, I, Thway, Y, Hodgson, S, Kim, J, Iwama, T, Novelli, M, Sheer, D, Poulsom, R, Wright, N, Houlston, R, Tomlinson, I

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. by Lamlum, H, Ilyas, M, Rowan, A, Clark, S, Johnson, V, Bell, J, Frayling, I, Efstathiou, J, Pack, K, Payne, S, Roylance, R, Gorman, P, Sheer, D, Neale, K, Phillips, R, Talbot, I, Bodmer, W, Tomlinson, I

Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q. by Lamlum, H, Al Tassan, N, Jaeger, E, Frayling, I, Sieber, O, Reza, F, Eckert, M, Rowan, A, Barclay, E, Atkin, W, Williams, C, Gilbert, J, Cheadle, J, Bell, J, Houlston, R, Bodmer, W, Sampson, J, Tomlinson, I

Molecular classification and genetic pathways in hyperplastic polyposis syndrome. by Carvajal-Carmona, L, Howarth, K, Lockett, M, Polanco-Echeverry, G, Volikos, E, Gorman, M, Barclay, E, Martin, L, Jones, A, Saunders, B, Guenther, T, Donaldson, A, Paterson, J, Frayling, I, Novelli, MR, Phillips, R, Thomas, H, Silver, A, Atkin, W, Tomlinson, I

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. by Sieber, O, Segditsas, S, Knudsen, A, Zhang, J, Luz, J, Rowan, A, Spain, S, Thirlwell, C, Howarth, K, Jaeger, E, Robinson, J, Volikos, E, Silver, A, Kelly, G, Aretz, S, Frayling, I, Hutter, P, Dunlop, M, Guenther, T, Neale, K, Phillips, R, Heinimann, K, Tomlinson, I

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. by Thompson, B, Spurdle, AB, Plazzer, J, Greenblatt, MS, Akagi, K, Al-Mulla, F, Bapat, B, Bernstein, I, Capellá, G, den Dunnen, J, du Sart, D, Fabre, A, Farrell, M, Farrington, S, Frayling, I, Frebourg, T, Goldgar, D, Heinen, C, Holinski-Feder, E, Kohonen-Corish, M, Robinson, K, Leung, S, Martins, A, Moller, P, Morak, M