Commentary: The landscape of transcription errors in eukaryotic cells nork Bert M. Verheijen, Fred W. van Leeuwen

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Editorial: Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System nork Ashok N. Hegde, Fred W. van Leeuwen

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Deposition of mutant ubiquitin in parkinsonism–dementia complex of Guam nork Bert M. Verheijen, Tomoyo Hashimoto, Kiyomitsu Oyanagi, Fred W. van Leeuwen

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Dysfunction of Protein Quality Control in Parkinsonism–Dementia Complex of Guam nork Bert M. Verheijen, Bert M. Verheijen, Kiyomitsu Oyanagi, Kiyomitsu Oyanagi, Fred W. van Leeuwen

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Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin nork Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo

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Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer’s disease nork Romina Jozefa Gentier, Bert M. Verheijen, Margherita eZamboni, Maartje M.A. Stroeken, Denise J.H.P. Hermes, Benno eKusters, Benno eKusters, Harry Wilhelm Maria Steinbusch, David A. Hopkins, David A. Hopkins, Fred W. Van Leeuwen

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Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast nork Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo

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Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model nork Inbal Maniv, Mahasen Sarji, Anwar Bdarneh, Alona Feldman, Roi Ankawa, Elle Koren, Inbar Magid-Gold, Noa Reis, Despina Soteriou, Shiran Salomon-Zimri, Tali Lavy, Ellina Kesselman, Naama Koifman, Thimo Kurz, Oded Kleifeld, Daniel Michaelson, Fred W. van Leeuwen, Bert M. Verheijen, Yaron Fuchs, Michael H. Glickman

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