Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues by Fredric P. Manfredsson, David C. Bloom, Ronald J. Mandel

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A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. by Tessa M Grabinski, Andrew Kneynsberg, Fredric P Manfredsson, Nicholas M Kanaan

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Characterizing the relationship between L-DOPA-induced-dyskinesia and psychosis-like behaviors in a bilateral rat model of Parkinson's disease by Natalie Lipari, Ashley Centner, John Glinski, Sophie Cohen, Fredric P. Manfredsson, Christopher Bishop

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The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson’s disease by Natalie Lipari, Ashley Galfano, Shruti Venkatesh, Han Grezenko, Ivette M. Sandoval, Fredric P. Manfredsson, Christopher Bishop

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Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates by Timothy J Collier, D Eugene Redmond, Kathy eSteece-Collier, Jack W Lipton, Fredric P Manfredsson

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A comparison of AAV-vector production methods for gene therapy and preclinical assessment by Marcus Davidsson, Matilde Negrini, Swantje Hauser, Alexander Svanbergsson, Marcus Lockowandt, Giuseppe Tomasello, Fredric P. Manfredsson, Andreas Heuer

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The Future of GDNF in Parkinson's Disease by Fredric P. Manfredsson, Nicole K. Polinski, Thyagarajan Subramanian, Nicholas Boulis, Dustin R. Wakeman, Dustin R. Wakeman, Ronald J. Mandel

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Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease by Shreaya Chakroborty, Fredric P. Manfredsson, Alexander M. Dec, Peter W. Campbell, Grace E. Stutzmann, Vahri Beaumont, Anthony R. West

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Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease by Zhi-Hao Wang, Jie Xiang, Xia Liu, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Shengxi Wu, Jian-Zhi Wang, Keqiang Ye

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Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age by Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, Kathy Steece-Collier

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IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy by Nicole J. Corbin-Stein, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms

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High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. by D Luke Fischer, Timothy J Collier, Allyson Cole-Strauss, Susan L Wohlgenant, Jack W Lipton, Kathy Steece-Collier, Fredric P Manfredsson, Christopher J Kemp, Caryl E Sortwell

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Devaluing memories of reward: a case for dopamine by Benjamin R. Fry, Nicolette Russell, Victoria Fex, Bing Mo, Nathan Pence, Joseph A. Beatty, Fredric P. Manfredsson, Brandon A. Toth, Christian R. Burgess, Samuel Gershman, Alexander W. Johnson

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Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS by Nicholas M. Kanaan, Rhyomi C. Sellnow, Sanford L. Boye, Ben Coberly, Antonette Bennett, Mavis Agbandje-McKenna, Caryl E. Sortwell, William W. Hauswirth, Shannon E. Boye, Fredric P. Manfredsson

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Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology by Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower

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Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease by Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye

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C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease by Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye

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The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats by Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier

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High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis by Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir EL Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay

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Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy by Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah E. Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D. Kelly, Matthew Goodson, Danica Lee, Fredric P. Manfredsson, Bob M. Moore II, Malú Gámez Tansey

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