Germline determinants of colorectal cancer risk and outcome Por Freeman-Mills, L

Somatic POLE proofreading domain mutation, immune response and prognosis in colorectal cancer: a retrospective, pooled biomarker study Por Domingo, E, Freeman-Mills, L, Rayner, E, Glaire, M, Briggs, S, Koelzer, V, Frangou, E, Dutton, P, Kerr, R, Kerr, D, Tomlinson, I, Church, D, EPICOLON consortium

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibitio... Por Eggink, F, Van Gool, I, Leary, A, Pollock, P, Crosbie, E, Mileshkin, L, Jordanova, E, Adam, J, Freeman-Mills, L, Church, D, Creutzberg, C, De Bruyn, M, Nijman, H, Bosse, T

POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer Por Klenerman, P, Church, D, Tomlinson, I, van Gool, I, Eggink, F, Freeman-Mills, L, Stelloo, E, Marchi, E, de Bruyn, M, Palles, C, Nout, R, de Kroon, C, Osse, E, Creutzberg, C, Smit, V, Nijman, H, Bosse, T

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding Por Lewis, A, Freeman-Mills, L, delaCalle-Mustienes, E, Giráldez-Pérez, R, Davis, H, Jaeger, E, Becker, M, Hubner, N, Nguyen, L, Zeron-Medina, J, Bond, G, Stunnenberg, H, Carvajal, J, Gomez-Skarmeta, J, Leedham, S, Tomlinson, I

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding. Por Lewis, A, Freeman-Mills, L, de la Calle-Mustienes, E, Giráldez-Pérez, R, Davis, H, Jaeger, E, Becker, M, Hubner, N, Nguyen, L, Zeron-Medina, J, Bond, G, Stunnenberg, H, Carvajal, J, Gomez-Skarmeta, J, Leedham, S, Tomlinson, I

Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis Por Bardella, C, Al-Dalahmah, O, Krell, D, Brazauskas, P, Tomkova, M, Al-Qahtani, K, Adam, J, Serres, S, Lockstone, H, Freeman-Mills, L, Pfeffer, I, Sibson, N, Goldin, R, Schuster-Böeckler, B, Pollard, P, Soga, T, McCullagh, J, Schofield, C, Mulholland, P, Ansorge, O, Kriaucionis, S, Ratcliffe, P, Szele, F, Tomlinson, I

Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis Por Bardella, C, Al-Dalahmah, O, Krell, D, Brazauskas, P, Tomkova, M, Adam, J, Serres, S, Lockstone, H, Freeman-Mills, L, Pfeffer, I, Sibson, N, Goldin, R, Schuster-Böeckler, B, Pollard, P, Soga, T, McCullagh, J, Schofield, C, Mulholland, P, Ansorge, O, Kriaucionis, S, Ratcliffe, P, Szele, F, Tomlinson, I, Al-Qahtani, K

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Por Davis, H, Irshad, S, Bansal, M, Rafferty, H, Boitsova, T, Bardella, C, Jaeger, E, Lewis, A, Freeman-Mills, L, Giner, F, Rodenas-Cuadrado, P, Mallappa, S, Clark, S, Thomas, H, Jeffery, R, Poulsom, R, Rodriguez-Justo, M, Novelli, M, Chetty, R, Silver, A, Sansom, O, Greten, F, Wang, L, East, J, Tomlinson, I, Leedham, S

A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS. Por Rosmarin, D, Palles, C, Pagnamenta, A, Kaur, K, Pita, G, Martin, M, Domingo, E, Jones, A, Howarth, K, Freeman-Mills, L, Johnstone, E, Wang, H, Love, S, Scudder, C, Julier, P, Fernández-Rozadilla, C, Ruiz-Ponte, C, Carracedo, A, Castellvi-Bel, S, Castells, A, Gonzalez-Neira, A, Taylor, J, Kerr, R, Kerr, D, Tomlinson, I

A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS Por Rosmarin, D, Palles, C, Pagnamenta, A, Kaur, K, Pita, G, Martin, M, Domingo, E, Jones, A, Howarth, K, Freeman-Mills, L, Johnstone, E, Wang, H, Love, S, Scudder, C, Julier, P, Fernández-Rozadilla, C, Ruiz-Ponte, C, Carracedo, A, Castellvi-Bel, S, Castells, A, Gonzalez-Neira, A, Taylor, J, Kerr, R, Kerr, D, Tomlinson, I

COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study Por Lee, LY, Cazier, J-B, Angelis, V, Arnold, R, Bisht, V, Campton, NA, Chackathayil, J, Cheng, VW, Curley, HM, Fittall, MW, Freeman-Mills, L, Gennatas, S, Goel, A, Hartley, S, Hughes, DJ, Kerr, D, Lee, AJ, Lee, RJ, McGrath, SE, Middleton, CP, Murugaesu, N, Newsom-Davis, T, Okines, AF, Olsson-Brown, AC, Palles, C, Pan, Y, Pettengell, R, Powles, T, Protheroe, EA, Purshouse, K, Sharma-Oates, A, Sivakumar, S, Smith, AJ, Starkey, T, Turnbull, CD, Várnai, C, Yousaf, N, UK Coronavirus Monitoring Project Team, Kerr, R, Middleton, G

Five endometrial cancer risk loci identified through genome-wide association analysis. Por Cheng, T, Thompson, D, O'Mara, T, Painter, J, Glubb, D, Flach, S, Lewis, A, French, J, Freeman-Mills, L, Church, D, Gorman, M, Martin, L, Hodgson, S, Webb, P, Attia, J, Holliday, E, McEvoy, M, Scott, R, Henders, A, Martin, N, Montgomery, G, Nyholt, D, Ahmed, S, Healey, C, Shah, M, Dennis, J, Fasching, P, Beckmann, M, Hein, A, Ekici, A, Hall, P, Czene, K, Darabi, H, Li, J, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, I, Amant, F, Schrauwen, S, Zhao, H, Lambrechts, D, Depreeuw, J, Dowdy, S, Goode, E, Fridley, B, Winham, S, Njølstad, T, Salvesen, H, Trovik, J, Werner, H, Ashton, K, Otton, G, Proietto, T, Liu, T, Mints, M, Tham, E, Li, M, Yip, S, Wang, J, Bolla, M, Michailidou, K, Wang, Q, Tyrer, J, Dunlop, M, Houlston, R, Palles, C, Hopper, J, Peto, J, Swerdlow, A, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, F, Giles, G, Kristensen, V, Cox, A, Cunningham, J, Pharoah, P, Dunning, A, Edwards, S, Easton, D, Tomlinson, I, Spurdle, A