Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites by Freinkman, Elizaveta, Chen, Walter W., Sabatini, David

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Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death by Freinkman, Elizaveta, Chan, Sze Ham, Lewis, Caroline, Sabatini, David M.

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Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism by Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David

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Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis by Endo, Tsutomu, Freinkman, Elizaveta, de Rooij, Dirk G., Page, David C

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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc

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Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes by Petrova, Boryana, Liu, Keke, Tian, Caiping, Kitaoka, Maiko, Freinkman, Elizaveta, Yang, Jing, Orr-Weaver, Terry

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Enhanced phosphocholine metabolism is essential for terminal erythropoiesis by Huang, Nai-Jia, Lin, Chung-Yueh, Pishesha, Novalia, Lewis, Caroline A., Freinkman, Elizaveta, Lodish, Harvey

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase by Cantor, Jason R., Abu-Remaileh, Monther, Kanarek, Naama, Freinkman, Elizaveta, Gao, Xin, Louissaint, Abner, Lewis, Caroline A., Sabatini, David

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Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes by Chan, Sze Ham, Freinkman, Elizaveta, Abu-Remaileh, Monther, Wyant, Gregory Andrew, Kim, Choah, Laqtom, Nouf N, Abbasi, Maria, Sabatini, David

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Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans by Tafesse, Fikadu G., Rashidfarrokhi, Ali, Freinkman, Elizaveta, Dougan, Stephanie, Dougan, Michael, Esteban, Alexandre, Maruyama, Takeshi, Strijbis, Karin, Schmidt, Florian Ingo, Ploegh, Hidde

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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient by Freinkman, Elizaveta, Wyant, Gregory Andrew, Abu-Remaileh, Monther, Wolfson, Rachel Laura, Chen, Walter W., Danai, Laura V, Vander Heiden, Matthew G., Sabatini, David

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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer by Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Chan, Sze Ham, Freinkman, Elizaveta, Lewis, Caroline A., Vander Heiden, Matthew G.

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Histidine catabolism is a major determinant of methotrexate sensitivity by Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Sabatini, David M.

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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin by Freinkman, Elizaveta, Thomas, Craig J., Gui, Dan Yi, Sullivan, Lucas Bryan, Luengo, Alba, Hosios, Aaron Marc, Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M, Vander Heiden, Matthew G.

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Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition by Freinkman, Elizaveta, Comb, William C., Cantor, Jason R., Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward

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Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging by Mihaylova, Maria M., Cheng, Chia-Wei, Cao, Amanda Q., Tripathi, Surya, Mana, Miyeko D., Bauer-Rowe, Khristian E., Abu-Remaileh, Monther, Clavain, Laura, Erdemir, Aysegul, Lewis, Caroline A., Freinkman, Elizaveta, Huang, Yanmei, Bell, George W., Sabatini, David M., Yilmaz, Ömer H.

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PIK3CA mutant tumors depend on oxoglutarate dehydrogenase by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward

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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers by Ji, B. W., Dixit, P. D., Wolpin, B. M., Vitkup, D., Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Hosios, Aaron Marc, Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler E., Vander Heiden, Matthew G.

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Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites by Schwartz, Schraga, Mumbach, Maxwell R., Jovanovic, Marko, Wang, Tim, Maciag, Karolina, Bushkin, G. Guy, Mertins, Philipp, Ter-Ovanesyan, Dmitry, Habib, Naomi, Cacchiarelli, Davide, Sanjana, Neville E., Freinkman, Elizaveta, Pacold, Michael E., Satija, Rahul, Hacohen, Nir, Zhang, Feng, Regev, Aviv, Mikkelsen, Tarjei Sigurd, 1978-, Carr, Steven A, Lander, Eric Steven

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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance by Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward

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