G.V. Shivashankar

G.V. Shivashankar (born 1968) is an Indian biophysicist working in the field of Mechanobiology. His research focuses on understanding the coupling between cell mechanics and genome organization for the regulation of cell homeostasis and cell state transitions. In addition his group also developed imaging-AI based chromatin biomarkers as fingerprints for cells in health and disease. Towards this, his group employs multi-scale correlative bio-imaging methods combined with bioengineered interfaces, functional genomics, theoretical modeling, and machine learning. He currently holds a full professorship for Mechano-Genomics at the Department of Health Sciences and Technology at ETH Zurich and he also heads the Laboratory of Nanoscale Biology at the Paul Scherrer Institute. Provided by Wikipedia
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  1. 1
    Mechanical force alters morphogenetic movements and segmental gene expression patterns during Drosophila embryogenesis.

    Mechanical force alters morphogenetic movements and segmental gene expression patterns during Drosophila embryogenesis. by Abhishek Kumar, G V Shivashankar

    Published 2012-01-01
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  2. 2
    Dynamics of passive and active particles in the cell nucleus.

    Dynamics of passive and active particles in the cell nucleus. by Feroz M Hameed, Madan Rao, G V Shivashankar

    Published 2012-01-01
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  3. 3
    Single cell imaging-based chromatin biomarkers for tumor progression

    Single cell imaging-based chromatin biomarkers for tumor progression by Saradha Venkatachalapathy, Doorgesh S. Jokhun, Madhavi Andhari, G. V. Shivashankar

    Published 2021-11-01
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  4. 4
    Actomyosin contractility as a mechanical checkpoint for cell state transitions

    Actomyosin contractility as a mechanical checkpoint for cell state transitions by Saradha Venkatachalapathy, Dyuthi Sreekumar, Prasuna Ratna, G. V. Shivashankar

    Published 2022-09-01
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  5. 5
    Graph-based autoencoder integrates spatial transcriptomics with chromatin images and identifies joint biomarkers for Alzheimer’s disease

    Graph-based autoencoder integrates spatial transcriptomics with chromatin images and identifies joint biomarkers for Alzheimer’s disease by Xinyi Zhang, Xiao Wang, G. V. Shivashankar, Caroline Uhler

    Published 2022-12-01
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  6. 6
    Role of actin dependent nuclear deformation in regulating early gene expression.

    Role of actin dependent nuclear deformation in regulating early gene expression. by Soumya Gupta, Nimi Marcel, Apurva Sarin, G V Shivashankar

    Published 2012-01-01
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  7. 7
    Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope

    Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope by Xiaowei Shao, Keiko Kawauchi, G. V. Shivashankar, Alexander D. Bershadsky

    Published 2015-11-01
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  8. 8
    Nuclear morphometrics and chromatin condensation patterns as disease biomarkers using a mobile microscope.

    Nuclear morphometrics and chromatin condensation patterns as disease biomarkers using a mobile microscope. by Karthik Damodaran, Michele Crestani, Doorgesh Sharma Jokhun, G V Shivashankar

    Published 2019-01-01
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  9. 9
    The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors

    The Linker Histone H1.2 Is an Intermediate in the Apoptotic Response to Cytokine Deprivation in T-Effectors by Megha Garg, Lakshmi R. Perumalsamy, G. V. Shivashankar, Apurva Sarin

    Published 2014-01-01
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  10. 10
    Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions

    Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions by Luezhen Yuan, Bibhas Roy, Prasuna Ratna, Caroline Uhler, G. V. Shivashankar

    Published 2022-10-01
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  11. 11
    Modeling and experimental methods to probe the link between global transcription and spatial organization of chromosomes.

    Modeling and experimental methods to probe the link between global transcription and spatial organization of chromosomes. by K Venkatesan Iyer, Shovamayee Maharana, Soumya Gupta, Albert Libchaber, Tsvi Tlusty, G V Shivashankar

    Published 2012-01-01
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  12. 12
    Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies

    Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies by Kiran Challa, Daniel Paysan, Dominic Leiser, Nadia Sauder, Damien C. Weber, G. V. Shivashankar

    Published 2023-12-01
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  13. 13
    Mechanical Strain Alters Cellular and Nuclear Dynamics at Early Stages of Oligodendrocyte Differentiation

    Mechanical Strain Alters Cellular and Nuclear Dynamics at Early Stages of Oligodendrocyte Differentiation by Ekta Makhija, Anna Jagielska, Anna Jagielska, Lena Zhu, Lena Zhu, Alexander C. Bost, Alexander C. Bost, William Ong, William Ong, Sing Y. Chew, Sing Y. Chew, Sing Y. Chew, G. V. Shivashankar, G. V. Shivashankar, G. V. Shivashankar, Krystyn J. Van Vliet, Krystyn J. Van Vliet, Krystyn J. Van Vliet

    Published 2018-03-01
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  14. 14
    Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS

    Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS by Xinyi Zhang, Saradha Venkatachalapathy, Daniel Paysan, Paulina Schaerer, Claudio Tripodo, Caroline Uhler, G. V. Shivashankar

    Published 2024-07-01
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  15. 15
    Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing

    Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing by Anastasiya Belyaeva, Louis Cammarata, Adityanarayanan Radhakrishnan, Chandler Squires, Karren Dai Yang, G. V. Shivashankar, Caroline Uhler

    Published 2021-02-01
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  16. 16
    DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

    DNA damage causes rapid accumulation of phosphoinositides for ATR signaling by Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz

    Published 2017-12-01
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  17. 17
    Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration.

    Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration. by Soumya Gupta, Nimi Marcel, Shefali Talwar, Megha Garg, Indulaxmi R, Lakshmi R Perumalsamy, Apurva Sarin, G V Shivashankar

    Published 2012-01-01
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  18. 18
    Multi-domain translation between single-cell imaging and sequencing data using autoencoders

    Multi-domain translation between single-cell imaging and sequencing data using autoencoders by Karren Dai Yang, Anastasiya Belyaeva, Saradha Venkatachalapathy, Karthik Damodaran, Abigail Katcoff, Adityanarayanan Radhakrishnan, G. V. Shivashankar, Caroline Uhler

    Published 2021-01-01
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  19. 19
    Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers

    Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers by Tina Pekeč, Saradha Venkatachalapathy, Anne R. Shim, Daniel Paysan, Michal Grzmil, Roger Schibli, Martin Béhé, G. V. Shivashankar

    Published 2023-11-01
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  20. 20
    Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

    Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance by Kuan Jiang, Su Bin Lim, Jingwei Xiao, Doorgesh Sharma Jokhun, Menglin Shang, Xiao Song, Pan Zhang, Lanfeng Liang, Boon Chuan Low, G.V. Shivashankar, Chwee Teck Lim

    Published 2023-08-01
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