Combined burden and functional impact tests for cancer driver discovery using DriverPower по Shuai, Shimin, Gallinger, Steven, Stein, Lincoln

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Differential gene expression profile reveals deregulation of pregnancy specific β1 glycoprotein 9 early during colorectal carcinogenesis по Salahshor, S, Goncalves, J, Chetty, R, Gallinger, S, Woodgett, JR

Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis. по Chetty, R, Salahshor, S, Bapat, B, Berk, T, Croitoru, M, Gallinger, S

Activation of Notch signaling in human colon adenocarcinoma. по Reedijk, M, Odorcic, S, Zhang, H, Chetty, R, Tennert, C, Dickson, B, Lockwood, G, Gallinger, S, Egan, SE

MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. по Hitchins, M, Williams, R, Cheong, K, Halani, N, Lin, V, Packham, D, Ku, S, Buckle, A, Hawkins, N, Burn, J, Gallinger, S, Goldblatt, J, Kirk, J, Tomlinson, I, Scott, R, Spigelman, A, Suter, C, Martin, D, Suthers, G, Ward, R

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer. по Whiffin, N, Dobbins, SE, Hosking, F, Palles, C, Tenesa, A, Wang, Y, Farrington, S, Jones, A, Broderick, P, Campbell, H, Newcomb, P, Casey, G, Conti, D, Schumacher, F, Gallinger, S, Lindor, N, Hopper, J, Jenkins, M, Dunlop, MG, Tomlinson, I, Houlston, R

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. по Theodoratou, E, Campbell, H, Tenesa, A, Houlston, R, Webb, E, Lubbe, S, Broderick, P, Gallinger, S, Croitoru, E, Jenkins, M, Win, A, Cleary, S, Koessler, T, Pharoah, P, Küry, S, Bézieau, S, Buecher, B, Ellis, N, Peterlongo, P, Offit, K, Aaltonen, L, Enholm, S, Lindblom, A, Zhou, X, Tomlinson, I

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants по Theodoratou, E, Campbell, H, Tenesa, A, Houlston, R, Webb, E, Lubbe, S, Broderick, P, Gallinger, S, Croitoru, E, Jenkins, M, Win, A, Cleary, S, Koessler, T, Pharoah, P, Küry, S, Bézieau, S, Buecher, B, Ellis, N, Peterlongo, P, Offit, K, Aaltonen, L, Enholm, S, Lindblom, A, Zhou, X, Tomlinson, I

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. по Tomlinson, I, Dunlop, M, Campbell, H, Zanke, B, Gallinger, S, Hudson, T, Koessler, T, Pharoah, P, Niittymäki, I, Niittymäkix, I, Tuupanen, S, Tuupanenx, S, Aaltonen, L, Hemminki, K, Lindblom, A, Försti, A, Sieber, O, Lipton, L, van Wezel, T, Morreau, H, Wijnen, J, Devilee, P, Matsuda, K, Nakamura, Y, Castellví-Bel, S

Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variati... по Carvajal-Carmona, L, Cazier, J, Jones, A, Howarth, K, Broderick, P, Pittman, A, Dobbins, S, Tenesa, A, Farrington, S, Prendergast, J, Theodoratou, E, Barnetson, R, Conti, D, Newcomb, P, Hopper, J, Jenkins, M, Gallinger, S, Duggan, D, Campbell, H, Kerr, D, Casey, G, Houlston, R, Dunlop, M, Tomlinson, I

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. по Whiffin, N, Hosking, F, Farrington, S, Palles, C, Dobbins, SE, Zgaga, L, Lloyd, A, Kinnersley, B, Gorman, M, Tenesa, A, Broderick, P, Wang, Y, Barclay, E, Hayward, C, Martin, L, Buchanan, D, Win, A, Hopper, J, Jenkins, M, Lindor, N, Newcomb, P, Gallinger, S, Conti, D, Schumacher, F, Casey, G

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. по Wolpin, B, Rizzato, C, Kraft, P, Kooperberg, C, Petersen, G, Wang, Z, Arslan, A, Beane-Freeman, L, Bracci, P, Buring, J, Canzian, F, Duell, E, Gallinger, S, Giles, G, Goodman, G, Goodman, P, Jacobs, E, Kamineni, A, Klein, A, Kolonel, L, Kulke, M, Li, D, Malats, N, Olson, S, Risch, H

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. по Tomlinson, I, Carvajal-Carmona, L, Dobbins, SE, Tenesa, A, Jones, A, Howarth, K, Palles, C, Broderick, P, Jaeger, E, Farrington, S, Lewis, A, Prendergast, J, Pittman, A, Theodoratou, E, Olver, B, Walker, M, Penegar, S, Barclay, E, Whiffin, N, Martin, L, Ballereau, S, Lloyd, A, Gorman, M, Lubbe, S, Howie, B, Marchini, J, Ruiz-Ponte, C, Fernandez-Rozadilla, C, Castells, A, Carracedo, A, Castellvi-Bel, S, Duggan, D, Conti, D, Cazier, J, Campbell, H, Sieber, O, Lipton, L, Gibbs, P, Martin, N, Montgomery, G, Young, J, Baird, P, Gallinger, S, Newcomb, P, Hopper, J, Jenkins, M, Aaltonen, L, Kerr, D, Cheadle, J, Pharoah, P, Casey, G, Houlston, R, Dunlop, MG

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis по May-Wilson, S, Sud, A, Law, PJ, Palin, K, Tuupanen, S, Gylfe, A, Hänninen, UA, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, AP, Eriksson, JG, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Mecklin, JP, Al-Tassan, NA, Palles, C, Farrington, SM, Timofeeva, MN, Meyer, BF, Wakil, SM, Campbell, H, Smith, CG, Idziaszczyk, S, Maughan, TS, Fisher, D, Kerr, R, Kerr, D, Passarelli, MN, Figueiredo, JC, Buchanan, DD, Win, AK, Hopper, JL, Jenkins, MA, Lindor, NM, Newcomb, PA, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Aaltonen, LA, Cheadle, JP, Tomlinson, IP, Dunlop, MG, Houlston, RS

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer по Jarvis, D, Mitchell, J, Law, P, Palin, K, Tuupanen, S, Gylfe, A, Hänninen, U, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A, Kaprio, J, Eriksson, J, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Meklin, J, Al-Tassan, N, Palles, C, Martin, L, Barclay, E, Farrington, S, Timofeeva, M, Meyer, B, Wakil, S, Campbell, H, Smith, C, Idziaszczyk, S, Maughan, T, Kaplan, R, Kerr, R, Kerr, D, Buchanan, D, Win, A, Hopper, J, Jenkins, M, Lindor, M, Newcomb, P, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Taipale, J, Aaltonen, L, Cheadle, J, Dunlop, M, Tomlinson, I, Houlston, R

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci по Tanskanen, T, van den Berg, L, Välimäki, N, Aavikko, M, Ness-Jensen, E, Hveem, K, Wettergren, Y, Lindskog, E, Tõnisson, N, Metspalu, A, Silander, K, Orlando, G, Law, PJ, Tuupanen, S, Gylfe, AE, Hänninen, UA, Cajuso, T, Kondelin, J, Sarin, AP, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Järvinen, H, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Mecklin, JP, Al-Tassan, NA, Palles, C, Martin, L, Barclay, E, Tenesa, A, Farrington, SM, Timofeeva, MN, Meyer, BF, Wakil, SM, Campbell, H, Smith, CG, Idziaszczyk, S, Maughan, TS, Kaplan, R, Kerr, R, Kerr, D, Buchanan, DD, Win, AK, Hopper, J, Jenkins, MA, Newcomb, PA, Gallinger, S, Conti, D, Schumacher, FR, Casey, G, Cheadle, JP, Dunlop, MG, Tomlinson, IP, Houlston, RS, Palin, K, Aaltonen, LA

An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population по Klein, A, Lindström, S, Mendelsohn, J, Steplowski, E, Arslan, A, Bueno-De-Mesquita, H, Fuchs, C, Gallinger, S, Gross, M, Helzlsouer, K, Holly, E, Jacobs, E, Lacroix, A, Li, D, Mandelson, M, Olson, S, Petersen, G, Risch, H, Stolzenberg-Solomon, R, Zheng, W, Amundadottir, L, Albanes, D, Allen, N, Bamlet, W, Boutron-Ruault, M, Buring, J, Bracci, P, Canzian, F, Clipp, S, Cotterchio, M, Duell, E, Elena, J, Gaziano, J, Giovannucci, E, Goggins, M, Hallmans, G, Hassan, M, Hutchinson, A, Hunter, D, Kooperberg, C, Kurtz, R, Liu, S, Overvad, K, Palli, D, Patel, A, Rabe, K, Shu, X, Slimani, N, Tobias, G, Trichopoulos, D, Van Den Eeden, S, Vineis, P, Virtamo, J, Wactawski-Wende, J, Wolpin, B, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Chanock, S, Hoover, R, Hartge, P, Kraft, P

Telomere structure and maintenance gene variants and risk of five cancer types по Karami, S, Han, Y, Pande, M, Cheng, I, Rudd, J, Pierce, BL, Nutter, EL, Schumacher, FR, Kote-Jarai, Z, Lindstrom, S, Witte, JS, Fang, S, Han, J, Kraft, P, Hunter, DJ, Song, F, Hung, RJ, McKay, J, Gruber, SB, Chanock, SJ, Risch, A, Shen, H, Haiman, CA, Boardman, L, Ulrich, CM, Casey, G, Peters, U, Olama, A, Berchuck, A, Berndt, SI, Bezieau, S, Brennan, P, Brenner, H, Brinton, L, Caporaso, N, Chan, AT, Chang-Claude, J, Christiani, DC, Cunningham, JM, Easton, D, Eeles, RA, Eisen, T, Gala, M, Gallinger, SJ, Gayther, SA, Goode, EL, Grönberg, H, Henderson, BE, Houlston, R, Joshi, AD, Küry, S, Landi, MT, Le Marchand, L, Muir, K, Newcomb, PA, Permuth-Wey, J, Pharoah, P, Phelan, C, Potter, JD, Ramus, SJ, Risch, H, Schildkraut, J, Slattery, ML, Song, H, Wentzensen, N, White, E, Wiklund, F, Zanke, BW, Sellers, TA, Zheng, W, Chatterjee, N, Amos, CI, Doherty, JA, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL

Association analyses identify 31 new risk loci for colorectal cancer susceptibility по Law, PJ, Timofeeva, M, Fernandez-Rozadilla, C, Broderick, P, Studd, J, Fernandez-Tajes, J, Farrington, S, Svinti, V, Palles, C, Orlando, G, Sud, A, Holroyd, A, Penegar, S, Theodoratou, E, Vaughan-Shaw, P, Campbell, H, Zgaga, L, Hayward, C, Campbell, A, Harris, S, Deary, IJ, Starr, J, Gatcombe, L, Pinna, M, Briggs, S, Martin, L, Jaeger, E, Sharma-Oates, A, East, J, Leedham, S, Arnold, R, Johnstone, E, Wang, H, Kerr, D, Kerr, R, Maughan, T, Kaplan, R, Al-Tassan, N, Palin, K, Hänninen, UA, Cajuso, T, Tanskanen, T, Kondelin, J, Kaasinen, E, Sarin, A-P, Eriksson, JG, Rissanen, H, Knekt, P, Pukkala, E, Jousilahti, P, Salomaa, V, Ripatti, S, Palotie, A, Renkonen-Sinisalo, L, Lepistö, A, Böhm, J, Mecklin, J-P, Buchanan, DD, Win, A-K, Hopper, J, Jenkins, ME, Lindor, NM, Newcomb, PA, Gallinger, S, Duggan, D, Casey, G, Hoffmann, P, Nöthen, MM, Jöckel, K-H, Easton, DF, Pharoah, PDP, Peto, J, Canzian, F, Swerdlow, A, Eeles, RA, Kote-Jarai, Z, Muir, K, Pashayan, N, Practical Consortium, Harkin, A, Allan, K, McQueen, J, Paul, J, Iveson, T, Saunders, M, Butterbach, K, Chang-Claude, J, Hoffmeister, M, Brenner, H, Kirac, I, Matošević, P, Hofer, P, Brezina, S, Gsur, A, Cheadle, JP, Aaltonen, LA, Tomlinson, I, Houlston, RS, Dunlop, MG

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. по Cheng, T, Thompson, D, Painter, J, O'Mara, T, Gorman, M, Martin, L, Palles, C, Jones, A, Buchanan, D, Ko Win, A, Hopper, J, Jenkins, M, Lindor, N, Newcomb, P, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Giles, G, Pharoah, P, Peto, J, Cox, A, Swerdlow, A, Couch, F, Cunningham, J, Goode, E, Winham, S, Lambrechts, D, Fasching, P, Burwinkel, B, Brenner, H, Brauch, H, Chang-Claude, J, Salvesen, H, Kristensen, V, Darabi, H, Li, J, Liu, T, Lindblom, A, Hall, P, de Polanco, M, Sans, M, Carracedo, A, Castellvi-Bel, S, Rojas-Martinez, A, Aguiar Jnr, S, Teixeira, M, Dunning, A, Dennis, J, Otton, G, Proietto, T, Holliday, E, Attia, J, Ashton, K, Scott, R, McEvoy, M, Dowdy, S, Fridley, B, Werner, H, Trovik, J, Njolstad, T, Tham, E, Mints, M, Runnebaum, I, Hillemanns, P, Dörk, T, Amant, F, Schrauwen, S, Hein, A, Beckmann, M, Ekici, A, Czene, K, Meindl, A, Bolla, M, Michailidou, K, Tyrer, J, Wang, Q, Ahmed, S, Healey, C, Shah, M, Annibali, D, Depreeuw, J, Al-Tassan, N, Harris, R, Meyer, B, Whiffin, N, Hosking, F, Kinnersley, B, Farrington, S, Timofeeva, M, Tenesa, A, Campbell, H, Haile, R, Hodgson, S, Carvajal-Carmona, L, Cheadle, J, Easton, D, Dunlop, M, Houlston, R, Spurdle, A, Tomlinson, I