Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel Autor Huang, J, Howie, B, McCarthy, S, Memari, Y, Walter, K, Min, J, Danecek, P, Malerba, G, Trabetti, E, Zheng, H, Gambaro, G, Richards, J, Durbin, R, Timpson, N, Marchini, J, Soranzo, N

Clinical and Economic Impact of Early Diagnosis of Chronic Kidney Disease in General Practice: The Endorse Study Autor Pesce F, Bruno GM, Colombo GL, Di Matteo S, Maurizi AR, Mongelli V, Mele S, Narici L, Bianchi S, Bonomini M, Castellano G, De Nicola L, Gambaro G, Grandaliano G, La Manna G, Pani A, Ranghino A, Gesualdo L

Získat plný text

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps Autor Iotchkova, V, Huang, J, Morris, J, Jain, D, Barbieri, C, Walter, K, Min, J, Chen, L, Astle, W, Cocca, M, Deelen, P, Elding, H, Farmaki, A, Franklin, C, Franberg, M, Gaunt, T, Hofman, A, Jiang, T, Kleber, M, Lachance, G, Luan, J, Malerba, G, Matchan, A, Mead, D, Memari, Y, Ntalla, I, Panoutsopoulou, K, Pazoki, R, Perry, J, Rivadeneira, F, Sabater-Lleal, M, Sennblad, B, Shin, S, Southam, L, Traglia, M, van Dijk, F, van Leeuwen, E, Zaza, G, Zhang, W, Amin, N, Butterworth, A, Chambers, J, Dedoussis, G, Dehghan, A, Franco, O, Franke, L, Frontini, M, Gambaro, G, Gasparini, P, Hamsten, A, Issacs, A, Kooner, J, Kooperberg, C, Langenberg, C, Marz, W, Scott, R, Swertz, M, Toniolo, D, Uitterlinden, A, van Duijn, C, Watkins, H, Zeggini, E, Maurano, M, Timpson, N, Reiner, A, Auer, P, Soranzo, N

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension Autor Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J, Manning, A, Grarup, N, Sim, X, Barnes, D, Witkowska, K, Staley, J, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A, Nielsen, S, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L, Jackson, A, Narisu, N, Swift, A, Southam, L, Marten, J, Huyghe, J, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K, Bork-Jensen, J, Gjesing, A, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, A, Zhang, H, Donnelly, L, Groves, C, Rayner, N, Neville, M, Robertson, N, Yiorkas, A, Herzig, K, Kajantie, E, Zhang, W, Willems, S, Lannfelt, L, Malerba, G, Soranzo, N, Trabetti, E, Verweij, N, Evangelou, E, Moayyeri, A, Vergnaud, A, Nelson, C, Poveda, A, Varga, T, Caslake, M, de Craen, A, Trompet, S, Luan, J, Scott, R, Harris, S, Liewald, D, Marioni, R, Menni, C, Farmaki, A, Hallmans, G, Renström, F, Huffman, J, Hassinen, M, Burgess, S, Vasan, R, Felix, J, Uria-Nickelsen, M, Malarstig, A, Reilly, D, Hoek, M, Vogt, T, Lin, H, Lieb, W, Traylor, M, Markus, H, Highland, H, Justice, A, Marouli, E, Lindström, J, Uusitupa, M, Komulainen, P, Lakka, T, Rauramaa, R, Polasek, O, Rudan, I, Rolandsson, O, Franks, P, Dedoussis, G, Spector, T, Jousilahti, P, Männistö, S, Deary, I, Starr, J, Langenberg, C, Wareham, N, Brown, M, Dominiczak, A, Connell, J, Jukema, J, Sattar, N, Ford, I, Packard, C, Esko, T, Mägi, R, Metspalu, A, de Boer, R, van der Meer, P, van der Harst, P, Gambaro, G, Ingelsson, E, Lind, L, de Bakker, P, Numans, M, Brandslund, I, Christensen, C, Petersen, E, Korpi-Hyövälti, E, Oksa, H, Chambers, J, Kooner, J, Blakemore, A, Franks, S, Jarvelin, M, Husemoen, L, Linneberg, A, Skaaby, T, Thuesen, B, Karpe, F, Tuomilehto, J, Doney, A, Morris, A, Palmer, C, Holmen, O, Hveem, K, Willer, C, Tuomi, T, Groop, L, Käräjämäki, A, Palotie, A, Ripatti, S, Salomaa, V, Alam, D, Majumder, A, Di Angelantonio, E, Chowdhury, R, McCarthy, M, Poulter, N, Stanton, A, Sever, P, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, Deloukas, P, Elliott, P, Zeggini, E, Kathiresan, S, Melander, O, Kuusisto, J, Laakso, M, Padmanabhan, S, Porteous, D, Hayward, C, Scotland, G, Collins, F, Mohlke, K, Hansen, T, Pedersen, O, Boehnke, M, Stringham, H, Frossard, P, Newton-Cheh, C, Tobin, M, Nordestgaard, B, Caulfield, M, Mahajan, A, Morris, A, Tomaszewski, M, Samani, N, Saleheen, D, Asselbergs, F, Lindgren, C, Danesh, J, Wain, L, Butterworth, A, Howson, J, Munroe, P

Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders Autor Ligthart, S, Vaez, A, Võsa, U, Stathopoulou, MG, De Vries, PS, Prins, BP, Van Der Most, PJ, Tanaka, T, Naderi, E, Rose, LM, Wu, Y, Karlsson, R, Barbalic, M, Lin, H, Pool, R, Zhu, G, Macé, A, Sidore, C, Trompet, S, Mangino, M, Sabater-Lleal, M, Kemp, JP, Abbasi, A, Kacprowski, T, Verweij, N, Smith, AV, Huang, T, Marzi, C, Feitosa, MF, Lohman, KK, Kleber, ME, Milaneschi, Y, Mueller, C, Huq, M, Vlachopoulou, E, Lyytikäinen, L-P, Oldmeadow, C, Deelen, J, Perola, M, Zhao, JH, Feenstra, B, Lifelines Cohort Study, Amini, M, Charge Inflammation Working Group, Lahti, J, Schraut, KE, Fornage, M, Suktitipat, B, Chen, W-M, Li, X, Nutile, T, Malerba, G, Luan, J, Bak, T, Schork, N, Del Greco M, F, Thiering, E, Mahajan, A, Marioni, RE, Mihailov, E, Eriksson, J, Ozel, AB, Zhang, W, Nethander, M, Cheng, Y-C, Aslibekyan, S, Ang, W, Gandin, I, Yengo, L, Portas, L, Kooperberg, C, Hofer, E, Rajan, KB, Schurmann, C, Hollander, W, Ahluwalia, TS, Zhao, J, Draisma, HHM, Ford, I, Timpson, N, Teumer, A, Huang, H, Wahl, S, Liu, Y, Huang, J, Uh, H-W, Geller, F, Joshi, PK, Yanek, LR, Trabetti, E, Lehne, B, Vozzi, D, Verbanck, M, Biino, G, Saba, Y, Meulenbelt, I, O'Connell, JR, Laakso, M, Giulianini, F, Magnusson, PKE, Ballantyne, CM, Hottenga, JJ, Montgomery, GW, Rivadineira, F, Rueedi, R, Steri, M, Herzig, K-H, Stott, DJ, Menni, C, Frånberg, M, St Pourcain, B, Felix, SB, Pers, TH, Bakker, SJL, Kraft, P, Peters, A, Vaidya, D, Delgado, G, Smit, JH, Großmann, V, Sinisalo, J, Seppälä, I, Williams, SR, Holliday, EG, Moed, M, Langenberg, C, Räikkönen, K, Ding, J, Campbell, H, Sale, MM, Chen, Y-DI, James, AL, Ruggiero, D, Soranzo, N, Hartman, CA, Smith, EN, Berenson, GS, Fuchsberger, C, Hernandez, D, Tiesler, CMT, Giedraitis, V, Liewald, D, Fischer, K, Mellström, D, Larsson, A, Wang, Y, Scott, WR, Lorentzon, M, Beilby, J, Ryan, KA, Pennell, CE, Vuckovic, D, Balkau, B, Concas, MP, Schmidt, R, De Leon, CF, Bottinger, EP, Kloppenburg, M, Paternoster, L, Boehnke, M, Musk, AW, Willemsen, G, Evans, DM, Madden, PAF, Kähönen, M, Kutalik, Z, Zoledziewska, M, Karhunen, V, Kritchevsky, SB, Sattar, N, Lachance, G, Clarke, R, Harris, TB, Raitakari, OT, Attia, JR, Van Heemst, D, Kajantie, E, Sorice, R, Gambaro, G, Scott, RA, Hicks, AA, Ferrucci, L, Standl, M, Lindgren, CM, Starr, JM, Karlsson, M, Lind, L, Li, JZ, Chambers, JC, Mori, TA, De Geus, EJCN, Heath, AC, Martin, NG, Auvinen, J, Buckley, BM, De Craen, AJM, Waldenberger, M, Strauch, K, Meitinger, T, Scott, RJ, McEvoy, M, Beekman, M, Bombieri, C, Ridker, PM, Mohlke, KL, Pedersen, NL, Morrison, AC, Boomsma, DI, Whitfield, JB, Strachan, DP, Hofman, A, Vollenweider, P, Cucca, F, Jarvelin, M-R, Jukema, JW, Spector, TD, Hamsten, A, Zeller, T, Uitterlinden, AG, Nauck, M, Gudnason, V, Qi, L, Grallert, H, Borecki, IB, Rotter, JI, März, W, Wild, PS, Lokki, M-L, Boyle, M, Salomaa, V, Melbye, M, Eriksson, JG, Wilson, JF, Penninx, BWJH, Becker, DM, Worrall, BB, Gibson, G, Krauss, RM, Ciullo, M, Zaza, G, Wareham, NJ, Oldehinkel, AJ, Palmer, LJ, Murray, SS, Pramstaller, PP, Bandinelli, S, Heinrich, J, Ingelsson, E, Deary, IJ, Mägi, R, Vandenput, L, Van Der Harst, P, Desch, KC, Kooner, JS, Ohlsson, C, Hayward, C, Lehtimäki, T, Shuldiner, AR, Arnett, DK, Beilin, LJ, Robino, A, Froguel, P, Pirastu, M, Jess, T, Koenig, W, Loos, RJF, Evans, DA, Schmidt, H, Smith, GD, Slagboom, PE, Eiriksdottir, G, Morris, AP, Psaty, BM, Tracy, RP, Nolte, IM, Boerwinkle, E, Visvikis-Siest, S, Reiner, AP, Gross, M, Bis, JC, Franke, L, Franco, OH, Benjamin, EJ, Chasman, DI, Dupuis, J, Snieder, H, Dehghan, A, Alizadeh, BZ