Gary Ruvkun

Ruvkun in 2024 Gary Bruce Ruvkun (born March 26, 1952) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston.

Ruvkun discovered the mechanism by which ''lin-4'', the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, ''let-7'', and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.

He was elected a Member of the American Philosophical Society in 2019. Ruvkun was awarded the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation. Provided by Wikipedia
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  1. 1
    Lifespan regulation by evolutionarily conserved genes essential for viability.

    Lifespan regulation by evolutionarily conserved genes essential for viability. by Sean P Curran, Gary Ruvkun

    Published 2007-04-01
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  2. 2
    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1 by Nicolas J Lehrbach, Gary Ruvkun

    Published 2016-08-01
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  3. 3
    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity by Nicolas J Lehrbach, Gary Ruvkun

    Published 2019-04-01
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  4. 4
    Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response.

    Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. by Kai Mao, Peter Breen, Gary Ruvkun

    Published 2020-12-01
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  5. 5
    Dual regulation of the lin-14 target mRNA by the lin-4 miRNA.

    Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. by Zhen Shi, Gabriel Hayes, Gary Ruvkun

    Published 2013-01-01
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  6. 6
    Functional genomic analysis of C. elegans molting.

    Functional genomic analysis of C. elegans molting. by Alison R Frand, Sascha Russel, Gary Ruvkun

    Published 2005-10-01
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  7. 7
    Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.

    Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. by Patrick J Hu, Jinling Xu, Gary Ruvkun

    Published 2006-07-01
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  8. 8
    Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.

    Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. by David E Shore, Christopher E Carr, Gary Ruvkun

    Published 2012-01-01
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  9. 9
    Genetic regulation of Caenorhabditis elegans lysosome related organelle function.

    Genetic regulation of Caenorhabditis elegans lysosome related organelle function. by Alexander A Soukas, Christopher E Carr, Gary Ruvkun

    Published 2013-10-01
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  10. 10
    Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes.

    Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. by Xiaoyun Wu, Zhen Shi, Mingxue Cui, Min Han, Gary Ruvkun

    Published 2012-01-01
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  11. 11
    CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing

    CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing by Angel Mojarro, Julie Hachey, Gary Ruvkun, Maria T. Zuber, Christopher E. Carr

    Published 2018-03-01
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  12. 12
    Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans

    Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans by Kurt Warnhoff, Sushila Bhattacharya, Jennifer Snoozy, Peter C Breen, Gary Ruvkun

    Published 2024-02-01
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  13. 13
    Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars

    Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars by Alexandra Pontefract, Alexandra Pontefract, Ting F. Zhu, Virginia K. Walker, Holli Hepburn, Clarissa Lui, Maria T. Zuber, Gary Ruvkun, Gary Ruvkun, Christopher E. Carr, Christopher E. Carr

    Published 2017-09-01
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  14. 14
    Gene pathways that delay Caenorhabditis elegans reproductive senescence.

    Gene pathways that delay Caenorhabditis elegans reproductive senescence. by Meng C Wang, Holly D Oakley, Christopher E Carr, Jessica N Sowa, Gary Ruvkun

    Published 2014-12-01
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  15. 15
    Prediction of C. elegans longevity genes by human and worm longevity networks.

    Prediction of C. elegans longevity genes by human and worm longevity networks. by Robi Tacutu, David E Shore, Arie Budovsky, João Pedro de Magalhães, Gary Ruvkun, Vadim E Fraifeld, Sean P Curran

    Published 2012-01-01
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  16. 16
    PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.

    PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. by Taiowa A Montgomery, Young-Soo Rim, Chi Zhang, Robert H Dowen, Carolyn M Phillips, Sylvia E J Fischer, Gary Ruvkun

    Published 2012-01-01
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  17. 17
    Genomic and Functional Characterization of Enterococcus faecalis Isolates Recovered From the International Space Station and Their Potential for Pathogenicity

    Genomic and Functional Characterization of Enterococcus faecalis Isolates Recovered From the International Space Station and Their Potential for Pathogenicity by Noelle C. Bryan, Francois Lebreton, Francois Lebreton, Michael Gilmore, Gary Ruvkun, Maria T. Zuber, Christopher E. Carr, Christopher E. Carr, Christopher E. Carr

    Published 2021-01-01
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  18. 18
    Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling

    Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling by Yuval Tabach, Tamar Golan, Abrahan Hernández‐Hernández, Arielle R Messer, Tomoyuki Fukuda, Anna Kouznetsova, Jian‐Guo Liu, Ingrid Lilienthal, Carmit Levy, Gary Ruvkun

    Published 2013-10-01
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  19. 19
    The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.

    The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. by Sylvia E J Fischer, Taiowa A Montgomery, Chi Zhang, Noah Fahlgren, Peter C Breen, Alexia Hwang, Christopher M Sullivan, James C Carrington, Gary Ruvkun

    Published 2011-11-01
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  20. 20
    Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.

    Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. by Ashwin Seetharaman, Himani Galagali, Elizabeth Linarte, Mona H X Liu, Jennifer D Cohen, Kashish Chetal, Ruslan Sadreyev, Alex J Tate, Taiowa A Montgomery, Gary Ruvkun

    Published 2025-01-01
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