A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. by Taranjit S Gujral, Gavin MacBeath

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High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways. by Jordan A Krall, Elsa M Beyer, Gavin MacBeath

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357 Discovery of a novel MAGEC2 epitope for TCR-T adoptive cell therapy from expanded T cell clones of TIL therapy products by Qikai Xu, Yifan Wang, Gavin MacBeath, Olivia Pryor, Cagan Gurer, Andrew Ferretti, Adam Weinheimer, Dalena Nguyen, Sarah Bertino

682 Trial in progress: phase 1 trial of TSC-100 and TSC-101, engineered T-cell therapies targeting minor histocompatibility antigens to eliminate residual disease after hematopoiet... by Yun Wang, Ran Reshef, Gavin MacBeath, Jim Murray, Debora Barton, Erica Buonomo, Shrikanta Chattopadhyay, Monzr Al Malki, Alla Keyzner, Hyung C Suh, Aasiya Matin, Nina Abelowitz

Suppression of Host p53 Is Critical for Plasmodium Liver-Stage Infection by Alexis Kaushansky, Albert S. Ye, Laura S. Austin, Sebastian A. Mikolajczak, Ashley M. Vaughan, Nelly Camargo, Peter G. Metzger, Alyse N. Douglass, Gavin MacBeath, Stefan H.I. Kappe

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156 Discovery of TSC-100: A natural HA-1-specific TCR to treat leukemia following hematopoietic stem cell transplant therapy by Kenneth Olivier, Ribhu Nayar, Sonal Jangalwe, Mollie Jurewicz, Antoine Boudot, Robert Prenovitz, Elizabeth Olesin, Daniel Pollacksmith, Qikai Xu, Yifan Wang, Amy Virbasius, Jeffery Li, Holly Whitton, Garrett Dunlap, Alexander Cristofaro, Nancy Nabilsi, Ruan Zhang, Candace Perullo, Sida Liao, Kenneth Jahan, Gavin MacBeath

709 Trial in progress: product characteristics and clinical trial design for T-Plex, a multiplexed, enhanced T cell receptor-engineered T cell therapy for solid tumors by Yun Wang, Ribhu Nayar, Mollie Jurewicz, Qikai Xu, Yifan Wang, Nancy Nabilsi, Gavin MacBeath, Marlyane Motta, Jim Murray, Debora Barton, Jenny Tadros, Badr Kiaf, Victor Ospina, Alok Das Mahopatra, Tary Traore, Antoine J Boudot, Cagan Gurer, Shrikanta Chattopadhyay, Hannah Bader, Chris Malcuit, Andrew Ferretti, Zhonghua Zhu, Krista Daniels, Briana Zimmerman, Amanda Kordosky, Ray Lockard

390 Discovery of MAGE-A1-specific TCR-T cell therapy candidates to expand multiplex therapy of solid tumors by Jin He, Ribhu Nayar, Mollie Jurewicz, Qikai Xu, Yifan Wang, Alexander Cristofaro, Nancy Nabilsi, Gavin MacBeath, Jenny Tadros, Akshat Sharma, Kenneth L Jahan, Nicolas Gaspar, Kimberly M Cirelli, Teagan Parsons, Shazad A Khokhar, Shubhangi Kamalia, Sveta Padmanabhan, Badr Kiaf, Victor Ospina, Alok Das Mahopatra, Tary Traore, Antoine J Boudot, Livio Dukaj, Ryan E Kritzer, Chandan K Pavuluri, Emily Miga, Cagan Gurer

376 Overcoming tumor heterogeneity – Clinical trial assays to prospectively assign patients customized multiplexed TCR-T cell therapy in Phase 1 by Yun Wang, Henry Tsai, Sam Harris, Andrew Nguyen, Ribhu Nayar, Sonal Jangalwe, Alexander Cristofaro, Nancy Nabilsi, Gavin MacBeath, Debora Barton, Ariane Lozac’hmeur, Qidi Yang, Teagan Parsons, Shazad A Khokhar, Sveta Padmanabhan, Antoine J Boudot, Livio Dukaj, Cagan Gurer, Jeffrey Coleman, Adam Hsiung, Chunghun Chang, Shehla Arain, Jessica Rathbun, Ruey Pham, Shardul Soni, Tyler Danek, Katie Marshall, Amanda Jensen, Chris Riley, Erica Buonomo, Shrikanta Chattopadhyay

364 Non-clinical development of T-Plex component TSC-200-A0201: a natural HPV16 E7-specific TCR-T cell therapy for the treatment of HPV16-positive solid tumors by Kenneth Olivier, Jin He, Ribhu Nayar, Sonal Jangalwe, Qikai Xu, Yifan Wang, Amy Virbasius, Alexander Cristofaro, Gavin MacBeath, Kenneth L Jahan, Nicolas Gaspar, Kimberly M Cirelli, Shazad A Khokhar, Shubhangi Kamalia, Sveta Padmanabhan, Badr Kiaf, Victor Ospina, Alok Das Mahopatra, Tary Traore, Antoine J Boudot, Livio Dukaj, Ryan E Kritzer, Chandan K Pavuluri, Daniel C Pollacksmith, Hannah Bader, Nivya Sharma, Debanjan Goswamy, Vivin Karthik, Elisaveta Todorova, Tyler M Sinacola, Savannah G Szemethy, Kyra N Sur, Vandana Keskar, Chris Malcuit, Danielle Ramsdell