Determining drug dose in the era of targeted therapies: playing it (un)safe? by Sigrid S. Skånland, Geir E. Tjønnfjord

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Long-lasting severe anemia following treatment with natalizumab for relapsing–remitting multiple sclerosis: a case report by Lars Henrik Dahl Hamnvik, Geir E. Tjønnfjord, Signe Spetalen, Jakob Dalgaard

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Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14)(q22;q32). by Synne Torkildsen, Ludmila Gorunova, Klaus Beiske, Geir E Tjønnfjord, Sverre Heim, Ioannis Panagopoulos

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Comparison between karyotyping-FISH-reverse transcription PCR and RNA-sequencing-fusion gene identification programs in the detection of KAT6A-CREBBP in acute myeloid leukemia. by Ioannis Panagopoulos, Synne Torkildsen, Ludmila Gorunova, Anne Tierens, Geir E Tjønnfjord, Sverre Heim

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Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case by Sigrid S. Skånland, Marit Inngjerdingen, Henrik Bendiksen, Jamie York, Signe Spetalen, Ludvig A. Munthe, Geir E. Tjønnfjord

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Heterozygous Mutations in Both the AMN and CBS Genes: Double Haploinsufficiency as an Unusual Cause of Vitamin B12 Deficiency—A Case Report by Per Ole Iversen, Jean‐Louis Gueant, Abderrahim Oussalah, Helga Refsum, Ebba Nexo, Geir E. Tjønnfjord, Christian Qvigstad

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The role of fat-soluble vitamins for graft-versus host disease after myeloablative conditioning in allogeneic stem cell transplanted patients by Kristin J. Skaarud, Anne Marte Gudmundstuen, Maiju Pesonen, Marianne J. Hjermstad, Per Ole Iversen, Geir E. Tjønnfjord

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Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma by Ulla Randen, Gunhild Trøen, Anne Tierens, Chloé Steen, Abdirashid Warsame, Klaus Beiske, Geir E. Tjønnfjord, Sigbjørn Berentsen, Jan Delabie

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Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report by Andreas Hanssønn Habberstad, Hoa Thi Tuyet Tran, Ulla Randen, Signe Spetalen, Ingunn Dybedal, Geir E. Tjønnfjord, Anders Erik Astrup Dahm

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Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells by Anna Parente-Ribes, Sigrid S. Skånland, Simone Bürgler, Audun Os, Dong Wang, Bjarne Bogen, Geir E. Tjønnfjord, Kjetil Taskén, Ludvig A. Munthe

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Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity by Agnieszka Małecka, Gunhild Trøen, Anne Tierens, Ingunn Østlie, Jędrzej Małecki, Ulla Randen, Sigbjørn Berentsen, Geir E. Tjønnfjord, Jan M.A. Delabie

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Chronic Lymphocytic Leukemia Cells Are Activated and Proliferate in Response to Specific T Helper Cells by Audun Os, Simone Bürgler, Anna Parente Ribes, Ane Funderud, Dong Wang, Keith M. Thompson, Geir E. Tjønnfjord, Bjarne Bogen, Ludvig A. Munthe

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Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically by Mariaserena Giliberto, Deepak B. Thimiri Govinda Raj, Andrea Cremaschi, Sigrid S. Skånland, Alexandra Gade, Geir E. Tjønnfjord, Fredrik Schjesvold, Ludvig A. Munthe, Kjetil Taskén

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Successful treatment of subcorneal pustular dermatosis targeting an underlying monoclonal IgA gammopathy by Ina Kreyberg, MD, PhD, Elisabeth Schrumpf, MD, PhD, Carl Fredrik von Krogh, MD, Rune Lilleng, MD, Geir E. Tjønnfjord, MD, PhD

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Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B‐cell malignancies by Katrine Melvold, Mariaserena Giliberto, Linda Karlsen, Pilar Ayuda‐Durán, Robert Hanes, Toril Holien, Jorrit Enserink, Jennifer R. Brown, Geir E. Tjønnfjord, Kjetil Taskén, Sigrid S. Skånland

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A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine by Johanne U. Hermansen, Yanping Yin, Aleksandra Urban, Camilla V. Myklebust, Linda Karlsen, Katrine Melvold, Anders A. Tveita, Kjetil Taskén, Ludvig A. Munthe, Geir E. Tjønnfjord, Sigrid S. Skånland

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P613: ANALYSIS OF EX-VIVO RESPONSE TO SINGLE DRUGS AND DRUG COMBINATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENT SAMPLES by Leonardo Miranda Santana, Deepak B. Thimiri Govinda Raj, Andrea Cremaschi, Mariaserena Giliberto, Alexandra Gade, Arnoldo Frigessi, Geir E. Tjønnfjord, Ludvig A. Munthe, Sigrid S. Skånland, Manuela Zucknick, Kjetil Taskén

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CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity by John F. Imbery, Celina Wiik, Julia Heinzelbecker, Jenny K. Jebsen, Mia K. Dobbing, Nunzio Bottini, Stephanie M. Stanford, Ludvig A. Munthe, Geir E. Tjønnfjord, Anders Tveita, Peter Szodoray, Britt Nakken

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Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial by Kristin J. Skaarud, Johannes R. Hov, Simen H. Hansen, Martin Kummen, Jørgen Valeur, Ingebjørg Seljeflot, Asta Bye, Vemund Paulsen, Knut E. A. Lundin, Marius Trøseid, Geir E. Tjønnfjord, Per Ole Iversen

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Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry by Cornelia Zeidler, Ulrike A.H. Grote, Anna Nickel, Beate Brand, Göran Carlsson, Emília Cortesão, Carlo Dufour, Caroline Duhem, Gundula Notheis, Helen A. Papadaki, Hannah Tamary, Geir E. Tjønnfjord, Fabio Tucci, Jan Van Droogenbroeck, Christiane Vermylen, Jaroslava Voglova, Blanca Xicoy, Karl Welte

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