Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity. by Klaus Gossens, Silvia Naus, Georg A Holländer, Hermann J Ziltener

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Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development by Adam E. Handel, Adam E. Handel, Noriko Shikama-Dorn, Saule Zhanybekova, Stefano Maio, Annina N. Graedel, Saulius Zuklys, Chris P. Ponting, Georg A. Holländer, Georg A. Holländer

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Deletion of PKBalpha/Akt1 affects thymic development. by Elisabeth Fayard, Jason Gill, Magdalena Paolino, Debby Hynx, Georg A Holländer, Brian A Hemmings

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Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors by Izumi Ohigashi, Saulius Zuklys, Mie Sakata, Carlos E. Mayer, Yoko Hamazaki, Nagahiro Minato, Georg A. Hollander, Yousuke Takahama

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Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT by Angela R. Smith, Ioanna A. Rota, Stefano Maio, Michel J. Massaad, Troy C. Lund, Luigi D. Notarangelo, Georg A. Holländer, Bruce R. Blazar

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Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development. by Heather E Stefanski, Yan Xing, Patricia A Taylor, Stefano Maio, Jorge Henao-Meija, Adam Williams, Richard A Flavell, Georg A Hollander, Bruce R Blazar

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Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells. by Rumi Satoh, Kiyokazu Kakugawa, Takuwa Yasuda, Hisahiro Yoshida, Maria Sibilia, Yoshimoto Katsura, Ben Levi, Jakub Abramson, Yoko Koseki, Haruhiko Koseki, Willem van Ewijk, Georg A Hollander, Hiroshi Kawamoto

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P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss by Heather E. Stefanski, Yan Xing, Jemma Nicholls, Leslie Jonart, Emily Goren, Patricia A. Taylor, Alea A. Mills, Megan Riddle, John McGrath, Jakub Tolar, Georg A. Hollander, Bruce R. Blazar

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P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss. by Heather E Stefanski, Yan Xing, Jemma Nicholls, Leslie Jonart, Emily Goren, Patricia A Taylor, Alea A Mills, Megan Riddle, John McGrath, Jakub Tolar, Georg A Hollander, Bruce R Blazar

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Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2 by Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer

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Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells by Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer

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Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla by Beth Lucas, Andrea J. White, Fabian Klein, Clara Veiga-Villauriz, Adam Handel, Andrea Bacon, Emilie J. Cosway, Kieran D. James, Sonia M. Parnell, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Georg A. Hollander, Wei-Yu Lu, Graham Anderson

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Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation by Alexandria C. Wells, Kaito A. Hioki, Constance C. Angelou, Adam C. Lynch, Xueting Liang, Daniel J. Ryan, Iris Thesmar, Saule Zhanybekova, Saulius Zuklys, Jacob Ullom, Agnes Cheong, Jesse Mager, Georg A. Hollander, Elena L. Pobezinskaya, Leonid A. Pobezinsky

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The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function by Bergithe E. Oftedal, Stefano Maio, Adam E. Handel, Madeleine P. J. White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fischer, Nikolaus S. Trede, Erdinc Sezgin, Rick M. Maizels, Georg A. Holländer

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Gene Modification and Three‐Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches by Ileana Bortolomai, Monica Sandri, Elena Draghici, Elena Fontana, Elisabetta Campodoni, Genni Enza Marcovecchio, Francesca Ferrua, Laura Perani, Antonello Spinelli, Tamara Canu, Marco Catucci, Tiziano Di Tomaso, Lucia Sergi Sergi, Antonio Esposito, Angelo Lombardo, Luigi Naldini, Anna Tampieri, Georg A. Hollander, Anna Villa, Marita Bosticardo

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Ageing compromises mouse thymus function and remodels epithelial cell differentiation by Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer

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In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering by Qianxin Wu, Quentin R. V. Ferry, Toni A. Baeumler, Yale S. Michaels, Dimitrios M. Vitsios, Omer Habib, Roland Arnold, Xiaowei Jiang, Stefano Maio, Bruno R. Steinkraus, Marta Tapia, Paolo Piazza, Ni Xu, Georg A. Holländer, Thomas A. Milne, Jin-Soo Kim, Anton J. Enright, Andrew R. Bassett, Tudor A. Fulga

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Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens by Joannah R. Fergusson, Michael D. Morgan, Melanie Bruchard, Leonie Huitema, Leonie Huitema, Balthasar A. Heesters, Vincent van Unen, Jan Piet van Hamburg, Jan Piet van Hamburg, Nicole N. van der Wel, Daisy Picavet, Frits Koning, Sander W. Tas, Sander W. Tas, Mark S. Anderson, John C. Marioni, John C. Marioni, John C. Marioni, Georg A. Holländer, Hergen Spits

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