A small molecule inhibitor of Rheb selectively targets mTORC1 signaling by Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah

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A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis. by James G Krueger, Mayte Suárez-Fariñas, Inna Cueto, Artemis Khacherian, Robert Matheson, Lawrence C Parish, Craig Leonardi, Denise Shortino, Akanksha Gupta, Jonathan Haddad, George P Vlasuk, Eric W Jacobson

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A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. by Vincenzo Libri, Andrew P Brown, Giulio Gambarota, Jonathan Haddad, Gregory S Shields, Helen Dawes, David J Pinato, Ethan Hoffman, Peter J Elliot, George P Vlasuk, Eric Jacobson, Martin R Wilkins, Paul M Matthews

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The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet by Sarah J. Mitchell, Alejandro Martin-Montalvo, Evi M. Mercken, Hector H. Palacios, Theresa M. Ward, Gelareh Abulwerdi, Robin K. Minor, George P. Vlasuk, James L. Ellis, David A. Sinclair, John Dawson, David B. Allison, Yongqing Zhang, Kevin G. Becker, Michel Bernier, Rafael de Cabo

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LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S] by Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk

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