P1056: NEXT GENERATION SEQUENCING IDENTIFIES SUBGROUPS OF PATIENTS WITH TRIPLE NEGATIVE/ PRIMARY THROMBOCYTOSIS WITH DIFFERENT CLINICAL OUTCOMES by Valentina Sangiorgio, Rocco Giovanni Piazza, Federica Mottadelli, Fabio Pagni, Inzoli Elena, Carlo Gambacorti-Passerini, Gianni Cazzaniga, Elena Maria Elli

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HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis by Alex Pezzotta, Ilaria Gentile, Donatella Genovese, Maria Grazia Totaro, Cristina Battaglia, Anskar Yu-Hung Leung, Monica Fumagalli, Matteo Parma, Gianni Cazzaniga, Grazia Fazio, Myriam Alcalay, Anna Marozzi, Anna Pistocchi

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A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia by Vaia Stavropoulou, Marwa Almosailleakh, Hélène Royo, Jean-François Spetz, Sabine Juge, Laurent Brault, Patrick Kopp, Michelina Iacovino, Michael Kyba, Alexandar Tzankov, Michael B. Stadler, Gianni Cazzaniga, Antoine H.F.M. Peters, Juerg Schwaller

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NIPBL: a new player in myeloid cell differentiation by Mara Mazzola, Gianluca Deflorian, Alex Pezzotta, Laura Ferrari, Grazia Fazio, Erica Bresciani, Claudia Saitta, Luca Ferrari, Monica Fumagalli, Matteo Parma, Federica Marasca, Beatrice Bodega, Paola Riva, Franco Cotelli, Andrea Biondi, Anna Marozzi, Gianni Cazzaniga, Anna Pistocchi

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The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. by Alessia Casolaro, Josee Golay, Clara Albanese, Roberta Ceruti, Veronica Patton, Sabrina Cribioli, Alice Pezzoni, Marco Losa, Gemma Texido, Ursula Giussani, Francesco Marchesi, Nadia Amboldi, Barbara Valsasina, Silvia Bungaro, Gianni Cazzaniga, Alessandro Rambaldi, Martino Introna, Enrico Pesenti, Rachele Alzani

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Clinical features and outcome of SIL/TAL1-positive T-cell acute lymphoblastic leukemia in children and adolescents: a 10-year experience of the AIEOP group by Mariella D’Angiò, Maria G. Valsecchi, Anna M. Testi, Valentino Conter, Vittorio Nunes, Rosanna Parasole, Antonella Colombini, Nicola Santoro, Stefania Varotto, Maurizio Caniglia, Daniela Silvestri, Caterina Consarino, Laura Levati, Elisa Magrin, Franco Locatelli, Giuseppe Basso, Robin Foà, Andrea Biondi, Gianni Cazzaniga

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Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis by Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam

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IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia by Bruno A. Lopes, Claus Meyer, Thayana C. Barbosa, Caroline P. Poubel, Marcela B. Mansur, Nicolas Duployez, Matthew Bashton, Christine J. Harrison, Udo zur Stadt, Martin Horstmann, Maria S. Pombo-de-Oliveira, Chiara Palmi, Gianni Cazzaniga, Nicola C. Venn, Rosemary Sutton, Cristina N. Alonso, Grigory Tsaur, Sanjeev K. Gupta, Sameer Bakhshi, Rolf Marschalek, Mariana Emerenciano

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Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts by Sabina Chiaretti, Antonella Vitale, Gianni Cazzaniga, Sonia Maria Orlando, Daniela Silvestri, Paola Fazi, Maria Grazia Valsecchi, Loredana Elia, Anna Maria Testi, Francesca Mancini, Valentino Conter, Geertruy te Kronnie, Felicetto Ferrara, Francesco Di Raimondo, Alessandra Tedeschi, Giuseppe Fioritoni, Francesco Fabbiano, Giovanna Meloni, Giorgina Specchia, Giovanni Pizzolo, Franco Mandelli, Anna Guarini, Giuseppe Basso, Andrea Biondi, Robin Foà

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P337: IKZF1 DELETIONS IN B-ALL: FROM ITS GENETIC BASIS TO DIAGNOSTIC ENHANCEMENT by Bruno A. Lopes, Claus Meyer, Heloysa Bouzada, Marius Külp, Ana Luiza Tardem Maciel, Patrizia Larghero, Thayana Da Conceição Barbosa, Caroline P. Poubel, Caroline Barbieri, Nicola C. Venn, Luciano Dalla-Pozza, Draga Barbaric, Chiara Palmi, Grazia Fazio, Claudia Saitta, Thais Ferraz Aguiar, Mecneide M. Lins, Maura R. V. Ikoma, Marcia Schramm, Eduardo Chapchap, Gianni Cazzaniga, Rosemary Sutton, Rolf Marschalek, Mariana Emerenciano

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Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts by Marco Ruella, Valentina Bertaina, Franco Locatelli, Antonio Camera, Biagio De Angelis, Francesca Del Bufalo, Concetta Quintarelli, Pietro Merli, Marika Guercio, Simona Manni, Iolanda Boffa, Matilde Sinibaldi, Stefano Di Cecca, Simona Caruso, Zeinab Abbaszadeh, Biancamaria Cembrola, Roselia Ciccone, Alberto Orfao, Lourdes Martin-Martin, Sara Gutierrez-Herrero, Maria Herrero-Garcia, Gianni Cazzaniga, Vittorio Nunes, Simona Songia, Paolo Marcatili, Frederikke I Marin, Luciana Vinti, Mattia Algeri

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Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency by Alvaro Muñoz-López, Damià Romero-Moya, Cristina Prieto, Verónica Ramos-Mejía, Antonio Agraz-Doblas, Ignacio Varela, Marcus Buschbeck, Anna Palau, Xonia Carvajal-Vergara, Alessandra Giorgetti, Anthony Ford, Majlinda Lako, Isabel Granada, Neus Ruiz-Xivillé, Sandra Rodríguez-Perales, Raul Torres-Ruíz, Ronald W. Stam, Jose Luis Fuster, Mario F. Fraga, Mahito Nakanishi, Gianni Cazzaniga, Michela Bardini, Isabel Cobo, Gustavo F. Bayon, Agustin F. Fernandez, Clara Bueno, Pablo Menendez

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More precisely defining risk peri-HCT in pediatric ALL: pre- vs post-MRD measures, serial positivity, and risk modeling by Peter Bader, Emilia Salzmann-Manrique, Adriana Balduzzi, Jean-Hugues Dalle, Ann E. Woolfrey, Merav Bar, Michael R. Verneris, Michael J. Borowitz, Nirali N. Shah, Nathan Gossai, Peter J. Shaw, Allen R. Chen, Kirk R. Schultz, Hermann Kreyenberg, Lucia Di Maio, Gianni Cazzaniga, Cornelia Eckert, Vincent H.J. van der Velden, Rosemary Sutton, Arjan Lankester, Christina Peters, Thomas E. Klingebiel, Andre M. Willasch, Stephan A. Grupp, Michael A. Pulsipher

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Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEO... by Gunnar Cario, Veronica Leoni, Valentino Conter, Andishe Attarbaschi, Marketa Zaliova, Lucie Sramkova, Gianni Cazzaniga, Grazia Fazio, Rosemary Sutton, Sarah Elitzur, Shai Izraeli, Melchior Lauten, Franco Locatelli, Giuseppe Basso, Barbara Buldini, Anke K. Bergmann, Jana Lentes, Doris Steinemann, Gudrun Göhring, Brigitte Schlegelberger, Oskar A. Haas, Denis Schewe, Swantje Buchmann, Anja Moericke, Deborah White, Tamas Revesz, Martin Stanulla, Georg Mann, Nicole Bodmer, Nira Arad-Cohen, Jan Zuna, Maria Grazia Valsecchi, Martin Zimmermann, Martin Schrappe, Andrea Biondi

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