The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1 by Gopal P. Sapkota

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Regulation of the transforming growth factor β pathway by reversible ubiquitylation by Mazin A. Al-Salihi, Lina Herhaus, Gopal P. Sapkota

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USP11 augments TGFβ signalling by deubiquitylating ALK5 by Mazin A. Al-Salihi, Lina Herhaus, Thomas Macartney, Gopal P. Sapkota

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Targeting endogenous proteins for degradation through the affinity-directed protein missile system by Luke J. Fulcher, Luke D. Hutchinson, Thomas J. Macartney, Craig Turnbull, Gopal P. Sapkota

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An affinity-directed protein missile system for targeted proteolysis by Luke J. Fulcher, Thomas Macartney, Polyxeni Bozatzi, Annika Hornberger, Alejandro Rojas-Fernandez, Gopal P. Sapkota

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Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA by Abigail Brewer, Gajanan Sathe, Billie E. Pflug, Rosemary G. Clarke, Thomas J. Macartney, Gopal P. Sapkota

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Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling by Janis Vogt, Kevin S. Dingwell, Lina Herhaus, Robert Gourlay, Thomas Macartney, David Campbell, James C. Smith, Gopal P. Sapkota

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Targeted dephosphorylation of TFEB promotes its nuclear translocation by Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota

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Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling by Abigail Brewer, Jin-Feng Zhao, Rotimi Fasimoye, Natalia Shpiro, Thomas J. Macartney, Nicola T. Wood, Melanie Wightman, Dario R. Alessi, Gopal P. Sapkota

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TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition by Anassuya Ramachandran, Pedro Vizán, Debipriya Das, Probir Chakravarty, Janis Vogt, Katherine W Rogers, Patrick Müller, Andrew P Hinck, Gopal P Sapkota, Caroline S Hill

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A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction by Lorraine Glennie, Marta Codina Solà, Mar Xunclà, Gloria Aparicio Español, Elena Garcia-Arumí, Eduardo Fidel Tizzano, Nicola T. Wood, Thomas J. Macartney, Amaia Lasa-Aranzasti, Gopal P. Sapkota

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Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 2; peer review: 2 approved] by Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota

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Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 1; peer review: 2 approved] by Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota

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USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling by Lina Herhaus, Mazin A. Al-Salihi, Kevin S. Dingwell, Timothy D. Cummins, Lize Wasmus, Janis Vogt, Richard Ewan, David Bruce, Thomas Macartney, Simone Weidlich, James C. Smith, Gopal P. Sapkota

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Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma by Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman

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