PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads. by Edward Seung, Timothy E Dudek, Todd M Allen, Gordon J Freeman, Andrew D Luster, Andrew M Tager

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PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity by Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M. Asara, Piotr Sicinski, Gordon J. Freeman, Wenyi Wei

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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion by Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J. Freeman, David J. Kwiatkowski, Elizabeth P. Henske

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An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy by Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup

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Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. by Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi

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The great debate at “Immunotherapy Bridge 2018”, Naples, November 29th, 2018 by Paolo A. Ascierto, Lisa H. Butterfield, Sandra Demaria, Robert L. Ferris, Gordon J. Freeman, Roger S. Lo, Alberto Mantovani, Paul Nathan, Omid Hamid, Katerina Politi, Igor Puzanov

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The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy by Apoorvi Chaudhri, Apoorvi Chaudhri, Apoorvi Chaudhri, Apoorvi Chaudhri, Xia Bu, Xia Bu, Yunfei Wang, Michael Gomez, Michael Gomez, James A. Torchia, James A. Torchia, Ping Hua, Ping Hua, Shao-Hsi Hung, Shao-Hsi Hung, Michael A. Davies, Gregory A. Lizee, Ulrich von Andrian, Ulrich von Andrian, Ulrich von Andrian, Patrick Hwu, Gordon J. Freeman, Gordon J. Freeman

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Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. by Nobuhiro Nakamoto, Hyosun Cho, Abraham Shaked, Kim Olthoff, Mary E Valiga, Mary Kaminski, Emma Gostick, David A Price, Gordon J Freeman, E John Wherry, Kyong-Mi Chang

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Regulation of HHLA2 expression in kidney cancer and myeloid cells by Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Kathleen M. Mahoney

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mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection by Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki

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TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. by Stephanie Jemielity, Jinyize J Wang, Ying Kai Chan, Asim A Ahmed, Wenhui Li, Sheena Monahan, Xia Bu, Michael Farzan, Gordon J Freeman, Dale T Umetsu, Rosemarie H Dekruyff, Hyeryun Choe

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T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity by Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine, Michael S. Goldberg

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Immunoregulatory effects of RGMb in gut inflammation by Magdiel Pérez-Cruz, Bettina P. Iliopoulou, Katie Hsu, Hsin-Hsu Wu, Tom Erkers, Kavya Swaminathan, Sai-Wen Tang, Cameron S. Bader, Neeraja Kambham, Bryan Xie, Rosemarie H. Dekruyff, Gordon J. Freeman, Everett Meyer

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Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function by Elsa Brunet-Ratnasingham, Antigoni Morou, Mathieu Dubé, Julia Niessl, Amy E. Baxter, Olivier Tastet, Nathalie Brassard, Gloria Ortega-Delgado, Roxanne Charlebois, Gordon J. Freeman, Cécile Tremblay, Jean-Pierre Routy, Daniel E. Kaufmann

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Down-regulation of CTLA-4 by HIV-1 Nef protein. by Mohamed El-Far, Catherine Isabelle, Nicolas Chomont, Martin Bourbonnière, Simone Fonseca, Petronela Ancuta, Yoav Peretz, Younes Chouikh, Rabih Halwani, Olivier Schwartz, Joaquín Madrenas, Gordon J Freeman, Jean-Pierre Routy, Elias K Haddad, Rafick-Pierre Sékaly

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Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis by Stinne R. Greisen, Stinne R. Greisen, Yan Yan, Aida S. Hansen, Morten T. Venø, Jens R. Nyengaard, Jens R. Nyengaard, Søren K. Moestrup, Søren K. Moestrup, Malene Hvid, Malene Hvid, Gordon J. Freeman, Jørgen Kjems, Bent Deleuran, Bent Deleuran

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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection by Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe

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Labeling Extracellular Vesicles for Nanoscale Flow Cytometry by Aizea Morales-Kastresana, Bill Telford, Thomas A. Musich, Katherine McKinnon, Cassandra Clayborne, Zach Braig, Ari Rosner, Thorsten Demberg, Dionysios C. Watson, Tatiana S. Karpova, Gordon J. Freeman, Rosemarie H. DeKruyff, George N. Pavlakis, Masaki Terabe, Marjorie Robert-Guroff, Jay A. Berzofsky, Jennifer C. Jones

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Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model by Yufei Wang, Jae-Won Cho, Gabriella Kastrunes, Alicia Buck, Cecile Razimbaud, Aedin C. Culhane, Jiusong Sun, David A. Braun, Toni K. Choueiri, Catherine J. Wu, Kristen Jones, Quang-De Nguyen, Zhu Zhu, Kevin Wei, Quan Zhu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco

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