Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency by Yanfeng Li, Chandan Guha, Patrik Asp, Xia Wang, Tatyana L. Tchaikovskya, Kenneth Kim, Matthew Mendel, Gregory J. Cost, David H. Perlmutter, Namita Roy-Chowdhury, Ira J. Fox, Anthony Conway, Jayanta Roy-Chowdhury

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Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells by Ryan Forster, Kunitoshi Chiba, Lorian Schaeffer, Samuel G. Regalado, Christine S. Lai, Qing Gao, Samira Kiani, Henner F. Farin, Hans Clevers, Gregory J. Cost, Andy Chan, Edward J. Rebar, Fyodor D. Urnov, Philip D. Gregory, Lior Pachter, Rudolf Jaenisch, Dirk Hockemeyer

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Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells by Ryan Forster, Kunitoshi Chiba, Lorian Schaeffer, Samuel G. Regalado, Christine S. Lai, Qing Gao, Samira Kiani, Henner F. Farin, Hans Clevers, Gregory J. Cost, Andy Chan, Edward J. Rebar, Fyodor D. Urnov, Philip D. Gregory, Lior Pachter, Rudolf Jaenisch, Dirk Hockemeyer

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Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes by Daniela S. Aliaga Goltsman, Lisa M. Alexander, Jyun-Liang Lin, Rodrigo Fregoso Ocampo, Benjamin Freeman, Rebecca C. Lamothe, Andres Perez Rivas, Morayma M. Temoche-Diaz, Shailaja Chadha, Natalie Nordenfelt, Owen P. Janson, Ian Barr, Audra E. Devoto, Gregory J. Cost, Cristina N. Butterfield, Brian C. Thomas, Christopher T. Brown

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1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells by Philip D Greenberg, Christopher A Klebanoff, Kim Nguyen, Gary Shapiro, Joshua Francis, Cheryl Black, Anthony Thomas, Meghan D Storlie, Allison P Drain, Nicholas Rouillard, Nathaniel Swanson, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, James Parsons, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Gregory J Cost, Thomas M Schmitt, Smita S Chandran, Ankit Gupta, Damien Hallet, Loic Vincent

355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses by Philip D Greenberg, Christopher A Klebanoff, Kim Nguyen, Gary Shapiro, Joshua Francis, Cheryl Black, Anthony Thomas, Meghan D Storlie, Allison P Drain, Nicholas Rouillard, Nathaniel Swanson, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, James Parsons, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Gregory J Cost, Thomas M Schmitt, Smita S Chandran, Ankit Gupta, Damien Hallet, Loic Vincent