The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis by Alice R. Moorey, Gurdyal S. Besra

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Top five unanswered questions in bacterial cell wall research by Sarah M. Batt, Katherine A. Abrahams, Gurdyal S. Besra

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Utilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria. by Panchali Kanvatirth, Rose E Jeeves, Joanna Bacon, Gurdyal S Besra, Luke J Alderwick

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Vanoxerine kills mycobacteria through membrane depolarization and efflux inhibition by Alexander D. H. Kingdon, Asti-Rochelle Meosa-John, Sarah M. Batt, Gurdyal S. Besra

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DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid by Katherine A. Abrahams, Sarah M. Batt, Sudagar S. Gurcha, Natacha Veerapen, Ghader Bashiri, Gurdyal S. Besra

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Enhanced immunogenicity of Mycobacterium bovis BCG through CRISPRi mediated depletion of AftC by Bala T.S.A. Madduri, Lauren Allen, Stephen C. Taylor, Gurdyal S. Besra, Luke J. Alderwick

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A humanized mouse model for in vivo evaluation of invariant Natural Killer T cell responses by Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli, Steven A. Porcelli

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NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo by Padam Singh, Srishti Rawat, Ashish Kumar Agrahari, Manisha Singh, Saurabh Chugh, Sudagar Gurcha, Albel Singh, Katherine Abrahams, Gurdyal S. Besra, Shailendra Asthana, Diwan S. Rawat, Ramandeep Singh

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Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis by Manisha Singh, Sarah M. Batt, Christian S. C. Canales, Fernando R. Pavan, Sethu Arun Kumar, Handattu S. Akshatha, Meduri Bhagyalalitha, Karthik G. Pujar, Durgesh Bidye, Gurubasavaraj V. Pujar, Gurdyal S. Besra

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Mycobacterium tuberculosis complex lipid virulence factors preserved in the 17,000-year-old skeleton of an extinct bison, Bison antiquus. by Oona Y-C Lee, Houdini H T Wu, Helen D Donoghue, Mark Spigelman, Charles L Greenblatt, Ian D Bull, Bruce M Rothschild, Larry D Martin, David E Minnikin, Gurdyal S Besra

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Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids by Maren Rudolph, Maren Rudolph, Yuting Wang, Yuting Wang, Yuting Wang, Theresa Simolka, Theresa Simolka, Emilie Huc-Claustre, Emilie Huc-Claustre, Lingyun Dai, Gijsbert Grotenbreg, Gurdyal Singh Besra, Anna Shevchenko, Andrej Shevchenko, Sebastian Zeissig, Sebastian Zeissig

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Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2 by Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao

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The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth by Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan

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Author Correction: The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth by Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan

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362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells by Sophie Papa, Luke Williams, Joseph Dukes, Jamie Rossjohn, Jonathan D Silk, Suzanne Cole, Emily Lam, Samit Kundu, Katarzyna Ward, Duncan Howie, Terri V Cornforth, Nathifa Moyo, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 1; referees: 2 approved, 1 approved with reservations] by Paul Fineran, Emyr Lloyd-Evans, Nathan A. Lack, Nick Platt, Lianne C. Davis, Anthony J. Morgan, Doris Höglinger, Raju Venkata V. Tatituri, Simon Clark, Ian M. Williams, Patricia Tynan, Nada Al Eisa, Evgeniya Nazarova, Ann Williams, Antony Galione, Daniel S. Ory, Gurdyal S. Besra, David G. Russell, Michael B. Brenner, Edith Sim, Frances M. Platt

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Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs by Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Sophie Papa, Jamie Rossjohn, Jamie Rossjohn, Duncan Howie, Joseph Dukes

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Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells by Suzanne E. Engelen, Francesca A. Ververs, Angela Markovska, B. Christoffer Lagerholm, Jordan M. Kraaijenhof, Laura I.E. Yousif, Yasemin-Xiomara Zurke, Can M.C. Gulersonmez, Sander Kooijman, Michael Goddard, Robert J. van Eijkeren, Peter J. Jervis, Gurdyal S. Besra, Saskia Haitjema, Folkert W. Asselbergs, Eric Kalkhoven, Hidde L. Ploegh, Marianne Boes, Vincenzo Cerundolo, G.K. Hovingh, Mariolina Salio, Edwin C.A. Stigter, Patrick C.N. Rensen, Claudia Monaco, Henk S. Schipper

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